Cited by 125Hormonal and reproductive studiesMuscle Physiology and DisordersNutrition and Health in Aging

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Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice

Axell, Anna-Maree, MacLean, Helen E., Plant, David R., Harcourt, Leah J., Davis, Jennifer A., Jimenez, Mark, Handelsman, David J., Lynch, Gordon S., Zajac, Jeffrey D.·2006·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00058.2006

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Abstract

Androgens promote anabolism in skeletal muscle; however, effects on subsequent muscle function are less well defined because of a lack of reliable experimental models. We established a rigorous model of androgen withdrawal and administration in male mice and assessed androgen regulation of muscle mass, structure, and function. Adult C57Bl/6J male mice were orchidectomized (Orx) or sham-operated (Sham) and received 10 wk of continuous testosterone (T) or control treatment (C) via intraperitoneal implants. Mass, fiber cross-sectional area (CSA), and in vitro contractile function were assessed for fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus (SOL) muscles. After 10 wk, Orx+C mice had reduced body weight gain ( P < 0.05), seminal vesicle mass ( P < 0.01), and levator ani muscle mass ( P < 0.001) compared with Sham+C mice, and these effects were prevented with testosterone treatment. Orx+T mice had greater EDL ( P < 0.01) and SOL ( P < 0.01) muscle mass compared with Orx+C mice; however, median fiber CSA was not significantly altered in these muscles. EDL and SOL muscle force was greater in Sham+T compared with Orx+C mice ( P < 0.05) in proportion to muscle mass. Unexpectedly, Orx+T mice had increased fatigue resistance of SOL muscle compared with Orx+C mice ( P < 0.001). We used a rigorous model of androgen withdrawal and administration in male mice to demonstrate an essential role of androgens in the maintenance of muscle mass and force. In addition, we showed that testosterone treatment increases resistance to fatigue of slow- but not fast-twitch muscle.

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Authors: Axell, A.-M., MacLean, H. E., Plant, D. R., Harcourt, L. J., Davis, J. A., Jimenez, M., Handelsman, D. J., Lynch, G. S., & Zajac, J. D.
Affiliations: The University of Melbourne (AU)
ORCID: Davis, Jennifer A.
Handelsman, David J.
Lynch, Gordon S.
Zajac, Jeffrey D.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2006-09
Volume: 291
Issue: 3
Pages: E506-E516
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00058.2006
OpenAlex: W2119647215
Cited by: 125
References: 73
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 11
FWCI: 2.94
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: testosterone, androgens, skeletal muscle atrophy, androgen withdrawal, orchiectomy, muscle fatigue resistance, muscle mass, muscle fiber cross-sectional area, slow-twitch muscle, fast-twitch muscle, extensor digitorum longus, soleus muscle, muscle force, male mice
MeSH terms: Animals, Body Weight, Male, Mice, Inbred C57BL, Muscle Contraction, Muscular Atrophy, Orchiectomy, Seminal Vesicles, Testis, Testosterone, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Muscle Fatigue, Mice

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Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice

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