Cited by 87Muscle Physiology and DisordersHormonal and reproductive studiesNerve injury and regeneration

Testosterone improves the regeneration of old and young mouse skeletal muscle

Open access
Serra, C., Tangherlini, F., Rudy, S., Lee, D., Toraldo, G., Sandor, N. L., Zhang, A., Jasuja, R. +1 more·2013·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

Aging is associated with loss of muscle mass and strength, reduced satellite cell number, and lower regenerative potential. Testosterone increases muscle mass, strength, and satellite cell number in humans; however, the effects of testosterone on the regenerative potential of skeletal muscle are unclear. Here, we investigated the effect of testosterone on the skeletal muscle regeneration of young (2-month-old) and aged (24-month-old) male mice. We show that testosterone increases the number of proliferating satellite cells in regenerating "tibialis anterior" muscle of young and aged castrated mice 2 and 4 days postinjury. Testosterone supplementation increases the number and the cross-sectional area of regenerating fibers in both classes of age 4 days postinjury. Testosterone increases satellite cell activation and proliferation and the regeneration of both young and aged mouse muscle. These data suggest prospective application of androgens to improve the regenerating potential of the aged human skeletal muscle.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/gerona/gls083

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Testosterone can promote muscle fiber regeneration and repair by activating muscle satellites and increasing cellular insulin-like growth factor-1 (IGF-1) levels.

    “Additionally, testosterone can promote muscle fiber regeneration and repair by activating muscle satellites and increasing cellular insulin-like growth factor-1 (IGF-1) levels (142, 143).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Serra, C., Tangherlini, F., Rudy, S., Lee, D., Toraldo, G., Sandor, N. L., Zhang, A., Jasuja, R., & Bhasin, S.
Affiliations
Boston University (US)
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2012-04-12
Volume
68
Issue
1
Pages
17-26
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2144647745
Cited by
87
References
58
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 1
FWCI
3.34
Type
journal article
Language
en
Open access
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Evans Medical Foundation
  • National Institutes of Health (5p30ag031679-15)
  • National Institute on Aging (R01AG037193, 5 P30 AG031679)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK070534)
  • National Center for Research Resources (UL1RR025771)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
testosterone, skeletal muscle regeneration, muscle aging, satellite cells, satellite cell proliferation, satellite cell activation, androgens, tibialis anterior, muscle damage, castration, muscle fiber cross-sectional area, muscle mass
MeSH terms
Aging, Animals, Cobra Cardiotoxin Proteins, Humans, Male, Mice, Inbred C57BL, Orchiectomy, Regeneration, Testosterone, Muscle, Skeletal, Myosin Heavy Chains, Neural Cell Adhesion Molecules, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review