Testosterone improves the regeneration of old and young mouse skeletal muscle
Open accessAbstract
Aging is associated with loss of muscle mass and strength, reduced satellite cell number, and lower regenerative potential. Testosterone increases muscle mass, strength, and satellite cell number in humans; however, the effects of testosterone on the regenerative potential of skeletal muscle are unclear. Here, we investigated the effect of testosterone on the skeletal muscle regeneration of young (2-month-old) and aged (24-month-old) male mice. We show that testosterone increases the number of proliferating satellite cells in regenerating "tibialis anterior" muscle of young and aged castrated mice 2 and 4 days postinjury. Testosterone supplementation increases the number and the cross-sectional area of regenerating fibers in both classes of age 4 days postinjury. Testosterone increases satellite cell activation and proliferation and the regeneration of both young and aged mouse muscle. These data suggest prospective application of androgens to improve the regenerating potential of the aged human skeletal muscle.
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Testosterone can promote muscle fiber regeneration and repair by activating muscle satellites and increasing cellular insulin-like growth factor-1 (IGF-1) levels.
“Additionally, testosterone can promote muscle fiber regeneration and repair by activating muscle satellites and increasing cellular insulin-like growth factor-1 (IGF-1) levels (142, 143).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [142]
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- Authors
- Serra, C., Tangherlini, F., Rudy, S., Lee, D., Toraldo, G., Sandor, N. L., Zhang, A., Jasuja, R., & Bhasin, S.
- Affiliations
- Boston University (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-12
- Volume
- 68
- Issue
- 1
- Pages
- 17-26
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3598367
- OpenAlex
- W2144647745
- Cited by
- 87
- References
- 58
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Evans Medical Foundation
- National Institutes of Health (5p30ag031679-15)
- National Institute on Aging (R01AG037193, 5 P30 AG031679)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK070534)
- National Center for Research Resources (UL1RR025771)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- testosterone, skeletal muscle regeneration, muscle aging, satellite cells, satellite cell proliferation, satellite cell activation, androgens, tibialis anterior, muscle damage, castration, muscle fiber cross-sectional area, muscle mass
- MeSH terms
- Aging, Animals, Cobra Cardiotoxin Proteins, Humans, Male, Mice, Inbred C57BL, Orchiectomy, Regeneration, Testosterone, Muscle, Skeletal, Myosin Heavy Chains, Neural Cell Adhesion Molecules, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice
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