Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

Chiu, C.-S.; Peekhaus, N.; Weber, H.; Adamski, S.; Murray, E. M.; Zhang, H. Z.; Zhao, J. Z.; Ernst, R.; Lineberger, J.; Huang, L.; Hampton, R.; Arnold, B. A.; Vitelli, S.; Hamuro, L.; Wang, W.-R.; Wei, N.; Dillon, G. M.; Miao, J.; Alves, S. E.; Glantschnig, H.; Wang, F.; Wilkinson, H. A.

doi:10.1093/gerona/glt030

Cited by 68Muscle Physiology and DisordersTGF-β signaling in diseasesHormonal and reproductive studies

Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

Chiu, C.-S., Peekhaus, N., Weber, H., Adamski, S., Murray, E. M., Zhang, H. Z., Zhao, J. Z., Ernst, R. +14 more·2013·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/glt030

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Abstract

Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A fusion protein consisting of the extracellular ligand-binding domain of activin type IIB receptor with the Fc portion of human immunoglobulin G (ActRIIB-Fc) was used to inhibit signaling through this pathway. Here, we study the effects of this fusion protein in adult, 18-month-old, and orchidectomized mice. Significant muscle growth and enhanced muscle function were observed in adult mice treated for 3 days with ActRIIB-Fc. The ActRIIB-Fc-treated mice had enhanced fast fatigable muscle function, with only minor enhancement of fatigue-resistant fiber function. The ActRIIB-Fc-treated 18-month-old mice and orchidectomized mice showed significantly improved muscle function. Treatment with ActRIIB-Fc also increased bone mineral density and serum levels of a marker of bone formation. These observations highlight the potential of targeting ActRIIB receptor to treat age-related and hypogonadism-associated musculoskeletal degeneration.

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Systemic administration of ACVR2B/Fc can lead to significant increases in bone density.
“Moreover, because this decoy receptor can block not only MSTN but also activin A, systemic administration of ACVR2B/Fc can also lead to significant increases in bone density (18–20).”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [19]

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Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
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Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function
Jeong, Y., Daghlas, S. A., Kahveci, A. S., Salamango, D. J., Gentry, B. A., Brown, M., Rector, R. S., Pearsall, R. S., & Phillips, C. L. (2017) · Muscle & Nerve · doi:10.1002/mus.25706 · Cited by 24 · see citing works

Authors: Chiu, C.-S., Peekhaus, N., Weber, H., Adamski, S., Murray, E. M., Zhang, H. Z., Zhao, J. Z., Ernst, R., Lineberger, J., Huang, L., Hampton, R., Arnold, B. A., Vitelli, S., Hamuro, L., Wang, W.-R., Wei, N., Dillon, G. M., Miao, J., Alves, S. E., Glantschnig, H., Wang, F., & Wilkinson, H. A.
Affiliations: Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
ORCID: Peekhaus, N.
Adamski, S.
Hamuro, L.
Dillon, G. M.
Wilkinson, H. A.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2013-03-22
Volume: 68
Issue: 10
Pages: 1181-1192
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glt030
OpenAlex: W2113036381
Cited by: 68
References: 71
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 6 · 2013: 6
FWCI: 4.62
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: myostatin, muscle growth, muscle force production, muscle function, bone mineral density, bone formation, aging, hypogonadism, orchiectomy, musculoskeletal degeneration, TGF-beta signaling
MeSH terms: Aging, Animals, Cell Line, Humans, Immunoglobulin Fc Fragments, Male, Mice, Inbred C57BL, Muscle Contraction, Orchiectomy, Peptide Fragments, Procollagen, Recombinant Fusion Proteins, Biomarkers, Bone Density, Activin Receptors, Type II, Mice, Muscle Strength, Myostatin, Sarcopenia, HEK293 Cells

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Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

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