The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood
Abstract
Chronic consumption of a high-fat (HF) diet by female rats in their postweaning period resulted in significant increases in body weight and plasma levels of insulin, glucose, and triglycerides during pregnancy compared with female rats consuming a standard rodent laboratory chow (LC). On gestational day 21, plasma insulin levels and the insulin secretory response of islets to various secretogogues were significantly increased in HF fetuses. The HF male progeny weaned onto LC (HF/LC) demonstrated increases in body weight from postnatal day 60 onward. In adulthood, HF/LC male rats were significantly heavier than controls, had increased plasma levels of insulin, glucose, free fatty acids, and triglycerides, and demonstrated glucose intolerance. HF/LC male islets secreted increased amounts of insulin in response to low glucose concentrations, but their response to a high glucose concentration was similar to that of LC/LC islets. In another set of experiments, when the male progeny of HF female rats were weaned onto a high-sucrose diet (HF/HSu), their metabolic profile was further worsened. These results indicate that chronic consumption of a HF diet by female rats malprograms the male progeny for glucose intolerance and development of increased body weight in adulthood. The long-term high-fat feeding to female rats employed in this study bears resemblance to the dietary habits in Western societies. The results of this study implicate dietary practices of women in the etiology of the present epidemic of human obesity and related disorders.
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Cites
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Gender-linked hypertension in offspring of lard-fed pregnant rats
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Cited by
Bruce, K. D., Cagampang, F. R., Argenton, M., Zhang, J., Ethirajan, P. L., Burdge, G. C., Bateman, A. C., Clough, G. F., Poston, L., Hanson, M. A., et al. (2009) · Hepatology · doi:10.1002/hep.23205 · Cited by 449
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
Developmental Programming in Response to Maternal Overnutrition
Alfaradhi, M. Z., & Ozanne, S. E. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00027 · Cited by 309
Wu, L. L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T.-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J., & Robker, R. L. (2015) · Development · doi:10.1242/dev.114850 · Cited by 276
Tozuka, Y., Kumon, M., Wada, E., Onodera, M., Mochizuki, H., & Wada, K. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.05.015 · Cited by 260
Metadata
- Authors
- Srinivasan, M., Katewa, S. D., Palaniyappan, A., Pandya, J. D., & Patel, M. S.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-10
- Volume
- 291
- Issue
- 4
- Pages
- E792-E799
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2099696895
- Cited by
- 255
- References
- 8
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. https://app.cochat.ai/papers/10.1152/ajpendo.00078.2006
- The paper
- Srinivasan, M., Katewa, S. D., Palaniyappan, A., Pandya, J. D., & Patel, M. S. (2006). Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00078.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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