Cited by 357Birth, Development, and HealthDiet, Metabolism, and DiseasePregnancy and preeclampsia studies

A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring

Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., Taylor, P. D.·2005·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1) pregnancy and 2) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams “cross fostered” to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.

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Crossref · 10.1152/ajpregu.00354.2004

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Authors
Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D.
Affiliations
King's College London (GB)
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
2005-01
Volume
288
Issue
1
Pages
R127-R133
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W2121804122
Cited by
357
References
33
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 22 · 2016: 24 · 2015: 21 · 2014: 22 · 2013: 23 · 2012: 19
FWCI
15.74
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
British Heart Foundation
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
high-fat diet, maternal diet, pregnancy, suckling, cardiovascular dysfunction, hypertension, metabolic syndrome, endothelial dysfunction, cross-fostering, hyperinsulinemia, adiposity, epigenetic programming, mesenteric small arteries
MeSH terms
Animals, Body Weight, Dietary Fats, Feeding Behavior, Female, Heart Rate, Hemodynamics, Lactation, Mesenteric Arteries, Pregnancy, Prenatal Exposure Delayed Effects, Vasodilation, Rats, Sprague-Dawley, Metabolic Syndrome, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Rats

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