Dietary fat intake does affect obesity!
Open accessAbstract
There is a difference of opinion about whether the percentage of dietary fat plays an important role in the rising prevalence of overweight and in its treatment once it has developed. We believe that ample research from animal and clinical studies, from controlled trials, and from epidemiologic and ecologic analyses provides strong evidence that dietary fat plays a role in the development and treatment of obesity. A reduction in fat intake reduces the gap between total energy intake and total energy expenditure and thus is an effective strategy for reducing the present epidemic of obesity worldwide. A review of the results from 28 clinical trials that studied the effects of a reduction in the amount of energy from fat in the diet showed that a reduction of 10% in the proportion of energy from fat was associated with a reduction in weight of 16 g/d. We thus conclude that dietary fat plays a role in the development of obesity. To reduce the prevalence of obesity, there must be an increase in energy expenditure, a reduction in total energy intake, or both. This goal can be facilitated by reducing the amount of fat in the diet.
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Excess dietary fat has also been implicated in the development of obesity and diabetes.
“Excess dietary fat has also been implicated in the development of obesity and diabetes (13).”
From A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle (2005) · cites this paper as [13]
The Conclusions state that high-fat diets contribute to obesity by increasing energy intake. The discussion on p. 1165 mentions weight loss in women who already had type 2 diabetes, but does not say excess dietary fat contributes to the development of diabetes. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDecreases in fat intake are associated with weight loss.
“Similarly, Bray and Popkin 27 and Yu-Poth and colleagues 15 found that decreases in fat intake were associated with weight loss.”
From Diet in the management of weight loss (2006) · cites this paper as [27]
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- Authors
- Bray, G. A., & Popkin, B. M.
- Affiliations
- Pennington Biomedical Research Center (US)
- ORCID
- Popkin, Barry M
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 68
- Issue
- 6
- Pages
- 1157-1173
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2098061260
- Cited by
- 1,123
- References
- 84
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 12 · 2023: 14 · 2022: 28 · 2021: 24 · 2020: 36 · 2019: 37 · 2018: 28 · 2017: 36 · 2016: 43 · 2015: 43 · 2014: 37 · 2013: 52 · 2012: 43
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (5r01dk032089-14)
- University of North Carolina at Chapel Hill (R01-HD30880)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-32089)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030880, R01 HD 30880)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dietary fat, obesity, overweight, energy balance, energy expenditure, energy intake, fat loss, weight loss, obesity prevention, clinical trials
- MeSH terms
- Animals, Energy Intake, Dietary Fats, Energy Metabolism, Humans, Obesity, Weight Loss
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