Cited by 311Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismLipid metabolism and biosynthesis

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Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro

Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., Pedersen, B. K.·2005·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00257.2004

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Abstract

To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes and/or whether it exerts this effect independently of changes to the hormonal milieu, patients with type 2 diabetes (D) and healthy control subjects (CON) underwent recombinant human (rh)IL-6 infusion for 3 h. Rates of appearance (Ra) and disappearance (Rd) of [U-(13C)]palmitate and [6,6-(2H2)]glucose were determined. rhIL-6 infusion increased (P < 0.05) palmitate Ra and Rd in a similar fashion in both groups. Neither plasma glucose concentration nor glucose Ra/Rd was affected by rhIL-6 infusion in either group, whereas rhIL-6 infusion resulted in a reduction (P < 0.05) in circulating insulin in D. Plasma growth hormone (GH) was increased (P < 0.05) by IL-6 in CON, and cortisol increased (P < 0.05) in response to IL-6 in both groups. To determine whether IL-6 was exerting its effect directly or through activation of these hormones, we performed cell culture experiments. Fully differentiated 3T3-L1 adipocytes were treated with PBS (control) IL-6, or IL-6 plus dexamethasone and GH. IL-6 treatment alone increased (P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted (P < 0.05) lipolysis compared with IL-6 alone. To assess whether IL-6 increases fat oxidation, L6 myotubes were treated with PBS (Control), IL-6, or AICAR, a compound known to increase lipid oxidation. Both IL-6 and AICAR markedly increased (P < 0.05) oxidation of [(14)C]palmitate compared with Control. Acute IL-6 treatment increased fatty acid turnover in D patients as well as healthy CON subjects. Moreover, IL-6 appears to be activating lipolysis independently of elevations in GH and/or cortisol and appears to be a potent catalyst for fat oxidation in muscle cells.

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Authors: Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K.
Affiliations: University of Copenhagen (DK)
RMIT University (AU)
The University of Melbourne (AU)
Commonwealth Scientific and Industrial Research Organisation (AU)
ORCID: Carey, A. L.
Sacchetti, M.
Steinberg, G. R.
Macaulay, S. L.
Febbraio, M. A.
Pedersen, B. K.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2005-01
Volume: 288
Issue: 1
Pages: E155-E162
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00257.2004
OpenAlex: W2145229644
Cited by: 311
References: 33
Citations by year: 2026: 6 · 2025: 10 · 2024: 18 · 2023: 10 · 2022: 16 · 2021: 17 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 9 · 2014: 17 · 2013: 26 · 2012: 22
FWCI: 9.74
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: interleukin-6, lipolysis, fat oxidation, fatty acid turnover, type 2 diabetes, adipocytes, skeletal muscle, growth hormone, cortisol, dexamethasone, insulin, AICAR, palmitate, 3T3-L1 adipocytes, L6 myotubes, older adults
MeSH terms: Aged, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glycerol, Hormones, Humans, Insulin, Lipolysis, Male, Middle Aged, Triglycerides, Interleukin-6, 3T3-L1 Cells, Mice, In Vitro Techniques

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Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro

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