Cited by 166Muscle metabolism and nutritionMuscle Physiology and DisordersCardiovascular and exercise physiology

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Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise

Cuthbertson, Daniel J., Babraj, John, Smith, Kenneth, Wilkes, Emilie, Fedele, Mark J., Esser, Karyn, Rennie, Michael·2006·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00415.2005

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Abstract

We hypothesized a differential activation of the anabolic signaling proteins protein kinase B (PKB) and p70 S6 kinase (p70S6K) and subsequent differential stimulation of human muscle protein synthesis (MPS) after dynamic shortening or lengthening exercise. Eight healthy men [25 ± 5 yr, BMI 26 ± 3 kg/m−2 (means ± SD)] were studied before and after 12 min of repeated stepping up to knee height, and down again, while carrying 25% of their body weight, i.e., shortening exercise with the “up” leg and lengthening exercise with contralateral “down” leg. Quadriceps biopsies were taken before and 3, 6, and 24 h after exercise. After exercise, over 2 h before the biopsies, the subjects ingested 500 ml of water containing 45 g of essential amino acids and 135 g of sucrose. Rates of muscle protein synthesis were determined via incorporation over time of [1-13C]leucine (≤6 h after exercise) or [1-13C]valine (21–24 h after exercise) and phosphorylation of signaling proteins by Western analysis. PKB and p70S6K phosphorylation increased ∼3-fold after 3 h and remained elevated at 6 and 24 h. After exercise, rates of myofibrillar and sarcoplasmic protein synthesis were unchanged over the period including exercise and 3 h of recovery but had increased significantly at 6 (∼3.0- and 2.4-fold, respectively) and 24 h (∼3.2- and 2.0-fold, respectively), independently of the mode of exercise. Short-term dynamic exercise in either shortening or lengthening mode increases MPS at least as much as resistance exercise and is associated with long-term activation of PKB and p70S6K.

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Authors: Cuthbertson, D. J., Babraj, J., Smith, K., Wilkes, E., Fedele, M. J., Esser, K., & Rennie, M.
Affiliations: Ninewells Hospital (GB)
University of Dundee (GB)
University of Nottingham (GB)
University of Illinois Urbana-Champaign (US)
University of Kentucky (US)
ORCID: Cuthbertson, Daniel J.
Babraj, John
Smith, Kenneth
Wilkes, Emilie
Esser, Karyn
Rennie, Michael
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2006-04
Volume: 290
Issue: 4
Pages: E731-E738
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00415.2005
OpenAlex: W2135780085
Cited by: 166
References: 42
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 9 · 2012: 7
FWCI: 3.66
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 45617, R01AR049869, AR49869, R01AR045617)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: muscle protein synthesis, anabolic signaling, Akt, p70 S6 kinase, dynamic exercise, quadriceps, myofibrillar protein synthesis, leucine incorporation, post-exercise recovery, resistance training
MeSH terms: Adult, Biopsy, Collagen, Humans, Leucine, Male, Muscle Proteins, Myofibrils, Phosphorylation, Random Allocation, Sarcoplasmic Reticulum, Valine, Blotting, Western, Signal Transduction, Exercise, Ribosomal Protein S6 Kinases, 70-kDa, Proto-Oncogene Proteins c-akt, Quadriceps Muscle

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Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise

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