The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The melanocortin system
Abstract
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four areas. In particular, recent pharmacological and genetic studies have affirmed the role of melanocortins in pigmentation, inflammation, energy homeostasis, and sexual function. Development of selective agonists and antagonists is expected to further facilitate the investigation of these complex physiological functions and provide an experimental basis for new pharmacotherapies.
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Citations
Cites
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
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Self-citationKrude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,733
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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
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“It has been estimated that MC4R mutations occur in 4% of severely obese French individuals (45).”
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Cited by
Mechanisms regulating melanogenesis*
Videira, I. F. D. S., Moura, D. F. L., & Magina, S. (2013) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962013000100009 · Cited by 677
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
Tao, Y.-X. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0037 · Cited by 531
Targeting melanocortin receptors as a novel strategy to control inflammation
Catania, A., Gatti, S., Colombo, G., & Lipton, J. M. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.1.1 · Cited by 438
Inflammation and neuropeptides: the connection in diabetic wound healing
Pradhan, L., Nabzdyk, C., Andersen, N. D., LoGerfo, F. W., & Veves, A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000945 · Cited by 285
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208
Metadata
- Authors
- Gantz, I., & Fong, T. M.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2003-03-01
- Volume
- 284
- Issue
- 3
- Pages
- E468-E474
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2169990586
- Cited by
- 466
- References
- 52
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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