The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Influence of TNF-α and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
Abstract
Inflammation is associated with insulin resistance, and both tumor necrosis factor (TNF)-α and interleukin (IL)-6 may affect glucose uptake. TNF induces insulin resistance, whereas the role of IL-6 is controversial. High plasma levels of IL-18 are associated with insulin resistance in epidemiological studies. We investigated the effects of TNF and IL-6 on IL-18 gene expression in skeletal muscle and adipose tissue. Nine human volunteers underwent three consecutive interventions, receiving an infusion of recombinant human (rh)IL-6, rhTNF, and saline. Insulin sensitivity was assessed by measurement of whole body glucose uptake with the stable isotope tracer method during a euglycemic hyperinsulinemic clamp (20 mU·min−1·kg−1), which was initiated 1 h after the IL-6-TNF-saline infusion. Cytokine responses were measured in plasma, muscle, and fat biopsies. Plasma concentrations of TNF and IL-6 increased 10- and 38-fold, respectively, during the cytokine infusions. Whole body insulin-mediated glucose uptake was significantly reduced during TNF infusion but remained unchanged during IL-6 infusion. TNF induced IL-18 gene expression in muscle tissue, but not in adipose tissue, whereas IL-6 infusion had no effect on IL-18 gene expression in either tissue. We conclude that TNF-induced insulin resistance of whole body glucose uptake is associated with increased IL-18 gene expression in muscle tissue, indicating that TNF and IL-18 interact, and both may have important regulatory roles in the pathogenesis of insulin resistance.
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BackgroundSelf-citationInterleukin-6-deficient mice develop mature-onset obesity
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Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Obesity, insulin resistance and free fatty acids
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Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters
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Metadata
- Authors
- Krogh-Madsen, R., Plomgaard, P., Møller, K., Mittendorfer, B., & Pedersen, B. K.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-07
- Volume
- 291
- Issue
- 1
- Pages
- E108-E114
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2030526970
- Cited by
- 180
- References
- 16
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krogh-Madsen, R., Plomgaard, P., Møller, K., Mittendorfer, B., & Pedersen, B. K. (2006). Influence of TNF-α and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00471.2005
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