The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
Abstract
This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were cannulated in the lateral ventricle and, after recovery, administered either intravenous STZ (50 mg/kg) to induce diabetes or citrate buffer. Chronic leptin (10 μg/10 μl icv) or vehicle injections were administered daily for 14 days beginning 2 days after establishment of hyperglycemia in the diabetic animals. At the end of the 2 wk of injections, insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. Blood glucose concentrations were dramatically reduced and normalized by the 4th day in diabetic animals receiving intracerebroventricular leptin treatment. Diabetic animals exhibited insulin resistance, whereas intracerebroventricular leptin significantly enhanced insulin sensitivity, as indicated by decreased SSPG. Circulating leptin levels were not increased in animals injected with intracerebroventricular leptin. Thus the increased peripheral insulin sensitivity appears to be due solely to the presence of leptin in the brain, not to leptin acting peripherally. These data imply that inadequate central leptin signaling may lead to insulin resistance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“i.c.v. administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally (43, 82, 104, 190).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [104]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
Leptin enters the brain by a saturable system independent of insulin
Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222
Caro, J. F., Kolaczynski, J. W., Nyce, M. R., Ohannesian, J. P., Opentanova, I., Goldman, W. H., Lynn, R. B., Zhang, P.-L., Sinha, M. K., & Considine, R. V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03173-x · Cited by 1,175
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Flagged first, then by citations
Research works printed but not linked: 3
- Chinookoswong N, 1998, Diabetes, 47, A72
- Kalra SP, 1999, Endocr Rev, 20, 68
- Kim YB, 1998, Diabetes, 47, A317
Cited by
Sorted by citations
Items 101–124 of 124
Wu, H., Wang, S., Tian, Y., Zhou, N., Wu, C., Li, R., Xu, W., Xu, T., Gu, L., Ji, F., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.829338 · Cited by 6
Leckström, A., Lew, P. S., Poritsanos, N. J., & Mizuno, T. M. (2011) · Neuropeptides · doi:10.1016/j.npep.2010.12.005 · Cited by 4
An acute method to test leptin responsiveness in rats
Desai, B. N., & Harris, R. B. S. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00548.2013 · Cited by 3
Pancreatic Islets as a Target of Adipokines
Reiterer, M., Gilani, A., & Lo, J. C. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210044 · Cited by 3
An overview of non-insulin adjunctive therapies for Type 1 diabetes
Ballav, C., & Gough, S. C. L. (2014) · Diabetes Management · doi:10.2217/dmt.14.38 · Cited by 2
Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes
Perry, R. J. (2017) · Postdoc Journal · doi:10.14304/surya.jpr.v5n1.2 · Cited by 2
THE RELATIONSHIP THE LEPTIN HORMONE, OBESITY AND DIABETES
Sarı, A., & Sadeq, M. B. (2020) · NWSA Academic Journals · doi:10.12739/nwsa.2020.15.2.3a0095 · Cited by 2
Pancreatic Islets as a Target of Adipokines
Reiterer, M., Gilani, A., & Lo, J. C. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00238.x · Cited by 1
Leptin and Intermediary Metabolism: Focus on Glucoregulation and Lipids
Morgan, R. C., & Considine, R. V. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_7
Leptin: A Metabolic Perspective
Penn, D. M., Rooks, C. R., & Harris, R. B. S. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn070
Modulação do metabolismo muscular da glicose pela ação hipotalâmica da leptina
Roman, E. A. D. F. R. (2011) · doi:10.47749/t/unicamp.2011.829153
Leptin Hormone in Health and Disease: Overview
M, R. A., I, S. A., & Odeh, S. O. (2015)
LaPierre, M. P. (2015) · TSpace (University of Toronto)
The metabolic effects of leptin therapy and glucagon suppression therapy in mouse models of diabetes
Neumann, U. H. (2017) · cIRcle (University of British Columbia) · doi:10.14288/1.0348695
CNS hormonal and nutritional regulation of glucose and energy homeostasis
Abraham, M. A. (2017) · TSpace (University of Toronto)
The Role of Central Glucagon Signaling in the Regulation of Glucose Homeostasis
Mighiu, P. I. (2012) · TSpace (University of Toronto)
Huneif, M. A., Shalayel, M. H. F., Hassan, E. E., Elhussein, A. B., Fadlelseed, O. E., Hamid, H. G. M., Elbadawi, A. A. A., Almedhesh, S. A., Alqahtani, S. M., Alqahtani, A. A., et al. (2022) · Medical Science · doi:10.54905/disssi/v26i120/ms64e2085
Leptin and Insulin Interaction Modulates Pancreatic Nitric Oxide Levels in Diabetic Rats
lmazer, N. Y., Kapucu, A. E., Gürevin, E. G., unova, S. Ü., Kandil, A., Tansel, C. D., Uyaner, L., & Dar, K. A. (2024) · International Journal of Pharmacology · doi:10.3923/ijp.2024.1292.1300
Gill, A., Gill, M., Mittal, R., Hirani, K., & Sharma, A. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000820 · Cited by 1
Impact of Insulin Resistance on Behavioral and Neurochemical Deficits in db/db Mice
Sharma, A. N. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
Kalra, S. P. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_20
Metadata
- Authors
- Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D.
- Affiliations
- Department of Nutrition and Food Science, and
- Auburn University (US)
- ORCID
- Lin, Chia-Yu
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-05-01
- Volume
- 282
- Issue
- 5
- Pages
- E1084-E1091
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2122422623
- Cited by
- 124
- References
- 43
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- leptin, insulin sensitivity, insulin resistance, streptozotocin-induced diabetes, blood glucose, hyperglycemia, type 2 diabetes
- MeSH terms
- Animals, Blood Glucose, Body Weight, Brain Chemistry, Diabetes Mellitus, Experimental, Eating, Fasting, Hyperglycemia, Injections, Intraventricular, Insulin, Insulin Resistance, Male, Signal Transduction, Rats, Wistar, Leptin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
