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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
Abstract
This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were cannulated in the lateral ventricle and, after recovery, administered either intravenous STZ (50 mg/kg) to induce diabetes or citrate buffer. Chronic leptin (10 μg/10 μl icv) or vehicle injections were administered daily for 14 days beginning 2 days after establishment of hyperglycemia in the diabetic animals. At the end of the 2 wk of injections, insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. Blood glucose concentrations were dramatically reduced and normalized by the 4th day in diabetic animals receiving intracerebroventricular leptin treatment. Diabetic animals exhibited insulin resistance, whereas intracerebroventricular leptin significantly enhanced insulin sensitivity, as indicated by decreased SSPG. Circulating leptin levels were not increased in animals injected with intracerebroventricular leptin. Thus the increased peripheral insulin sensitivity appears to be due solely to the presence of leptin in the brain, not to leptin acting peripherally. These data imply that inadequate central leptin signaling may lead to insulin resistance.
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“i.c.v. administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally (43, 82, 104, 190).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [104]
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- Chinookoswong N, 1998, Diabetes, 47, A72
- Kalra SP, 1999, Endocr Rev, 20, 68
- Kim YB, 1998, Diabetes, 47, A317
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“Similarly, intracerebroventricular administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally (43, 82, 104, 190).”
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Metadata
- Authors
- Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D.
- Affiliations
- Department of Nutrition and Food Science, and
- Auburn University (US)
- ORCID
- Lin, Chia-Yu
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-05-01
- Volume
- 282
- Issue
- 5
- Pages
- E1084-E1091
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2122422623
- Cited by
- 124
- References
- 43
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- leptin, insulin sensitivity, insulin resistance, streptozotocin-induced diabetes, blood glucose, hyperglycemia, type 2 diabetes
- MeSH terms
- Animals, Blood Glucose, Body Weight, Brain Chemistry, Diabetes Mellitus, Experimental, Eating, Fasting, Hyperglycemia, Injections, Intraventricular, Insulin, Insulin Resistance, Male, Signal Transduction, Rats, Wistar, Leptin, Rats
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