Cited by 124Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetes

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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

Lin, Chia-Yu, Higginbotham, D. Allan, Judd, Robert L., White, B. Douglas·2002·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00489.2001

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Abstract

This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were cannulated in the lateral ventricle and, after recovery, administered either intravenous STZ (50 mg/kg) to induce diabetes or citrate buffer. Chronic leptin (10 μg/10 μl icv) or vehicle injections were administered daily for 14 days beginning 2 days after establishment of hyperglycemia in the diabetic animals. At the end of the 2 wk of injections, insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. Blood glucose concentrations were dramatically reduced and normalized by the 4th day in diabetic animals receiving intracerebroventricular leptin treatment. Diabetic animals exhibited insulin resistance, whereas intracerebroventricular leptin significantly enhanced insulin sensitivity, as indicated by decreased SSPG. Circulating leptin levels were not increased in animals injected with intracerebroventricular leptin. Thus the increased peripheral insulin sensitivity appears to be due solely to the presence of leptin in the brain, not to leptin acting peripherally. These data imply that inadequate central leptin signaling may lead to insulin resistance.

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Self-citation
Opposite Effects of Chronic Central Leptin Infusion on Activation of Insulin Signaling Pathways in Adipose Tissue and Liver Are Related to Changes in the Inflammatory Environment
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In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus
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Authors: Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D.
Affiliations: Department of Nutrition and Food Science, and
Auburn University (US)
ORCID: Lin, Chia-Yu
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2002-05-01
Volume: 282
Issue: 5
Pages: E1084-E1091
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00489.2001
OpenAlex: W2122422623
Cited by: 124
References: 43
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: leptin, insulin sensitivity, insulin resistance, streptozotocin-induced diabetes, blood glucose, hyperglycemia, type 2 diabetes
MeSH terms: Animals, Blood Glucose, Body Weight, Brain Chemistry, Diabetes Mellitus, Experimental, Eating, Fasting, Hyperglycemia, Injections, Intraventricular, Insulin, Insulin Resistance, Male, Signal Transduction, Rats, Wistar, Leptin, Rats

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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

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