Cited by 93Pregnancy and preeclampsia studiesBirth, Development, and HealthCholesterol and Lipid Metabolism

Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition

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Wadsack, Christian, Tabano, Silvia, Maier, Alexandra, Hiden, Ursula, Alvino, Gioia, Cozzi, Veronica, Hüttinger, Manfred, Schneider, Wolfgang J. +3 more·2007·American Journal of Physiology-Endocrinology and Metabolism

Abstract

Among other factors, fetal growth requires maternal supply of cholesterol. Cellular cholesterol uptake is mainly mediated by the LDL receptor (LDL-R) and the scavenger receptor family. We hypothesized that expression levels of key receptors of these families were regulated differently in placentas from IUGR pregnancies with varying degrees of severity. Third-trimester placentas from IUGR pregnancies with (IUGR-S) and without (IUGR-M) fetal hemodynamic changes and from control (AGA) pregnancies were studied. LDL-R, LDL-R-related protein (LRP-1), and scavenger receptor class B type I (SR-BI) mRNA and protein levels were measured. Cholesterol concentration and composition of lipoproteins were analyzed enzymatically and by lipid electrophoresis, respectively, in maternal and umbilical cord blood. LDL-R mRNA levels in IUGR-M were similar to AGA but lower ( P < 0.05) in IUGR-S. In contrast, LDL-R protein was twofold (IUGR-M) and 1.8-fold (IUGR-S) higher ( P < 0.05) than in the AGA group. LRP-1 mRNA and protein levels were not altered in the IUGR cases. SR-BI mRNA was unchanged in IUGR, but protein levels were lower ( P < 0.05) in IUGR-S than in the other groups. Maternal plasma concentrations of LDL cholesterol were higher ( P < 0.05) in the AGA group (188.5 ± 23.6 mg/dl) than in the IUGR-S group (154.2 ± 26.1). Electrophoretic mobility of the LDL fraction in maternal plasma demonstrated significant changes in migration toward higher values (AGA 0.95 ± 0.06, IUGR-M 1.12 ± 0.11, P < 0.001; IUGR-S 1.28 ± 0.20, P = 0.002). We conclude that LDL-R and SR-BI levels are altered in IUGR pregnancies. These differences were associated with changes in LDL, but not HDL, mobility and cholesterol concentration in maternal circulation.

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Crossref · 10.1152/ajpendo.00547.2005

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Authors
Wadsack, C., Tabano, S., Maier, A., Hiden, U., Alvino, G., Cozzi, V., Hüttinger, M., Schneider, W. J., Lang, U., Cetin, I., & Desoye, G.
Affiliations
  • Medical University of Graz (AT)
  • University of Milan (IT)
  • Max Perutz Labs (AT)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2007-02
Volume
292
Issue
2
Pages
E476-E484
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2130305589
Cited by
93
References
47
Citations by year
2025: 3 · 2024: 7 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
5.90
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders
Imperial College London
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
fetal growth restriction, placenta, LDL receptor, scavenger receptor class B type I, LDL receptor-related protein 1, lipoprotein receptors, LDL cholesterol, cholesterol absorption, fetal hemodynamics, umbilical cord blood, lipoprotein electrophoretic mobility
MeSH terms
Adult, Cholesterol, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Lipoproteins, Maternal-Fetal Exchange, Middle Aged, Placenta, Pregnancy, Receptors, LDL, Receptors, Lipoprotein, Low Density Lipoprotein Receptor-Related Protein-1

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