Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition
Open accessAbstract
Among other factors, fetal growth requires maternal supply of cholesterol. Cellular cholesterol uptake is mainly mediated by the LDL receptor (LDL-R) and the scavenger receptor family. We hypothesized that expression levels of key receptors of these families were regulated differently in placentas from IUGR pregnancies with varying degrees of severity. Third-trimester placentas from IUGR pregnancies with (IUGR-S) and without (IUGR-M) fetal hemodynamic changes and from control (AGA) pregnancies were studied. LDL-R, LDL-R-related protein (LRP-1), and scavenger receptor class B type I (SR-BI) mRNA and protein levels were measured. Cholesterol concentration and composition of lipoproteins were analyzed enzymatically and by lipid electrophoresis, respectively, in maternal and umbilical cord blood. LDL-R mRNA levels in IUGR-M were similar to AGA but lower ( P < 0.05) in IUGR-S. In contrast, LDL-R protein was twofold (IUGR-M) and 1.8-fold (IUGR-S) higher ( P < 0.05) than in the AGA group. LRP-1 mRNA and protein levels were not altered in the IUGR cases. SR-BI mRNA was unchanged in IUGR, but protein levels were lower ( P < 0.05) in IUGR-S than in the other groups. Maternal plasma concentrations of LDL cholesterol were higher ( P < 0.05) in the AGA group (188.5 ± 23.6 mg/dl) than in the IUGR-S group (154.2 ± 26.1). Electrophoretic mobility of the LDL fraction in maternal plasma demonstrated significant changes in migration toward higher values (AGA 0.95 ± 0.06, IUGR-M 1.12 ± 0.11, P < 0.001; IUGR-S 1.28 ± 0.20, P = 0.002). We conclude that LDL-R and SR-BI levels are altered in IUGR pregnancies. These differences were associated with changes in LDL, but not HDL, mobility and cholesterol concentration in maternal circulation.
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- Authors
- Wadsack, C., Tabano, S., Maier, A., Hiden, U., Alvino, G., Cozzi, V., Hüttinger, M., Schneider, W. J., Lang, U., Cetin, I., & Desoye, G.
- Affiliations
- Medical University of Graz (AT)
- University of Milan (IT)
- Max Perutz Labs (AT)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2007-02
- Volume
- 292
- Issue
- 2
- Pages
- E476-E484
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2130305589
- Cited by
- 93
- References
- 47
- Citations by year
- 2025: 3 · 2024: 7 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Imperial College London
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- fetal growth restriction, placenta, LDL receptor, scavenger receptor class B type I, LDL receptor-related protein 1, lipoprotein receptors, LDL cholesterol, cholesterol absorption, fetal hemodynamics, umbilical cord blood, lipoprotein electrophoretic mobility
- MeSH terms
- Adult, Cholesterol, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Lipoproteins, Maternal-Fetal Exchange, Middle Aged, Placenta, Pregnancy, Receptors, LDL, Receptors, Lipoprotein, Low Density Lipoprotein Receptor-Related Protein-1
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