Decreased very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas from preeclamptic pregnancies
Abstract
Objective Our purpose was to investigate the levels of very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas obtained from normal pregnant women at various gestational stages and from patients with preeclampsia.Study design The relative level of expression of very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid in each sample was determined by Northern blot analysis as a ratio of the intensity to that of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid.Results The expression of very-low-density lipoprotein receptor messenger ribonucleic acid increased significantly (p < 0.05) from both the first (n = 9) and second (n = 8) trimesters to the third (n = 11) trimester. Similarly, the expression of low-density lipoprotein receptor messenger ribonucleic acid increased significantly (p < 0.05) from the first to the third trimester. The expression of both very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acids in third-trimester placentas from preeclamptic pregnancies (n = 13) was significantly lower than that in normal pregnancies in the third trimester.Conclusion These results demonstrate the expression of very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acids in the human placenta, both of which increase at late gestational stages, and the decreased expression in cases of preeclampsia. Abnormal fetomaternal lipid metabolism resulting from low expression of these receptors in the placenta may be involved in the pathogenesis of preeclampsia.
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Expression of the mRNAs encoding the VLDL-R and LDL-R increases across gestation, but is suppressed at term in pregnancies complicated by pre-eclampsia and severe growth restriction.
“Expression of the mRNAs encoding the VLDL-R and LDL-R increases across gestation (402, 580), but is suppressed at term in pregnancies complicated by pre-eclampsia and severe growth restriction (402, 552).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [402]
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Placental Origins of Chronic Disease
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- Authors
- Murata, M., Kodama, H., Goto, K., Hirano, H., & Tanaka, T.
- Affiliations
- Akita University (JP)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 175
- Issue
- 6
- Pages
- 1551-1556
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1971670165
- Cited by
- 23
- References
- 27
- Citations by year
- 2025: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2016: 2 · 2014: 1 · 2012: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, VLDLR, LDL receptor, placenta, mRNA expression, gestational age, lipoprotein metabolism, preeclampsia pathogenesis
- MeSH terms
- Adult, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Receptors, LDL, Reference Values, RNA, Messenger, Blotting, Northern
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