Review: Transport of maternal cholesterol to the fetal circulation

Woollett, L.A.

doi:10.1016/j.placenta.2011.01.011

Cited by 173Cholesterol and Lipid MetabolismPregnancy and preeclampsia studiesCancer, Lipids, and Metabolism

Review: Transport of maternal cholesterol to the fetal circulation

Woollett, L.A.·2011·Placenta

DOI 10.1016/j.placenta.2011.01.011

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Abstract

Data obtained from recent studies in humans, rodents, and cell culture demonstrate that circulating maternal cholesterol can be transported to the fetus. The two major cell types responsible for the transport are trophoblasts and endothelial cells of the fetoplacental vasculature. Maternal lipoprotein-cholesterol is initially taken up by trophoblasts via receptor-mediated and receptor-independent processes, is transported by any number of the sterol transport proteins expressed by cells, and is effluxed or secreted out of the basal side via protein-mediated processes or by aqueous diffusion. This cholesterol is then taken up by the endothelium and effluxed to acceptors within the fetal circulation. The ability to manipulate the mass of maternal cholesterol that is taken up by the placenta and crosses to the fetus could positively impact development of fetuses affected with the Smith-Lemli-Opitz Syndrome (SLOS) that have reduced ability to synthesize cholesterol and possibly impact growth of fetuses unaffected by SLOS but with low birthweights.

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Placental lipoprotein uptake represents an important step in the maternal-fetal transfer of cholesterol.
“However, placental lipoprotein uptake represents an important step in the maternal-fetal transfer of cholesterol (584).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [584]

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Authors: Woollett, L. A.
Affiliations: University of Cincinnati (US)
Corresponding author: Woollett, L.A.
Venue: Placenta
Publisher: Elsevier BV
Published: 2011-03
Volume: 32
Pages: S218-S221
ISSN: 0143-4004 (ISSN-L)
DOI: 10.1016/j.placenta.2011.01.011
OpenAlex: W2052324612
Cited by: 173
References: 50
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 13 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 10
FWCI: 1.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Placenta (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-34089, R56HD034089, R01HD034089)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: maternal cholesterol, trophoblast, endothelial cells, cholesterol efflux, Smith-Lemli-Opitz syndrome, low birth weight, fetal development
MeSH terms: Animals, Biological Transport, Cholesterol, Female, Fetus, Humans, Maternal-Fetal Exchange, Pregnancy, Smith-Lemli-Opitz Syndrome

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Review: Transport of maternal cholesterol to the fetal circulation

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