The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function
Abstract
Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or de novo lipogenesis serve a variety of functions in skeletal muscle. The two major fates of fatty acids are mitochondrial oxidation to provide energy for the myocyte and storage within a variety of lipids, where they are stored primarily in discrete lipid droplets or serve as important structural components of membranes. In this review, we provide a brief overview of skeletal muscle fatty acid metabolism and highlight recent notable advances in the field. We then 1) discuss how lipids are stored in and mobilized from various subcellular locations to provide adaptive or maladaptive signals in the myocyte and 2) outline how lipid metabolites or metabolic byproducts derived from the actions of triacylglycerol metabolism or β-oxidation act as positive and negative regulators of insulin action. We have placed an emphasis on recent developments in the lipid biology field with respect to understanding skeletal muscle physiology and discuss unanswered questions and technical limitations for assessing lipid signaling in skeletal muscle.
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“an accumulation of these fatty acids and ceramides and diacylglycerol in the cytosolic compartment are linked to insulin resistance via an inhibition of the insulin signaling cascade (36,37).”
From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [37]
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Metadata
- Authors
- Watt, M. J., & Hoy, A. J.
- Affiliations
- Monash University (AU)
- Corresponding author
- Watt, Matthew J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-06-01
- Volume
- 302
- Issue
- 11
- Pages
- E1315-E1328
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2033804400
- Cited by
- 142
- References
- 208
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 15 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 7
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- skeletal muscle lipid metabolism, fatty acid metabolism, lipolysis, de novo lipogenesis, lipid droplets, mitochondrial fatty acid oxidation, fatty acid beta-oxidation, lipid signaling, insulin action, adipose tissue lipolysis, membrane lipids
- MeSH terms
- Adaptation, Physiological, Animals, Fatty Acids, Humans, Insulin Resistance, Lipids, Triglycerides, Signal Transduction, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism
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