Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

Kishimoto, A., Takai, Y., Terutoshi, M. O. R. I., Kikkawa, U., & Nishizuka, Y. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85886-6 · Cited by 1,303

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179

Skeletal muscle triglyceride levels are inversely related to insulin action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

Hannun, Y. A., Loomis, C. R., Merrill, A. H., & Bell, R. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67133-9 · Cited by 1,156

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903

Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome

Lass, A., Zimmermann, R., Haemmerle, G., Riederer, M., Schoiswohl, G., Schweiger, M., Kienesberger, P. C., Bogner‐Strauß, J. G., Gorkiewicz, G., & Zechner, R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.03.005 · Cited by 884

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877

Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets

Greenberg, A. S., Egan, J. J., Wek, S. A., Garty, N. B., Blanchette‐Mackie, E. J., & Londos, C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99168-4 · Cited by 831

Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities

Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., & Gross, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407841200 · Cited by 778

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

Lass, A., Zimmermann, R., Oberer, M., & Zechner, R. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.004 · Cited by 677

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 677

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

Haus, J. M., Kashyap, S. R., Kasumov, T., Zhang, R., Kelly, K. R., DeFronzo, R. A., & Kirwan, J. P. (2008) · Diabetes · doi:10.2337/db08-1228 · Cited by 665

Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans

Baron, A., Brechtel, G., Wallace, P., & Edelman, S. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e769 · Cited by 645

Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids

Villena, J. A., Roy, S., Sarkadi‐Nagy, E., Kim, K., & Sul, H. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403855200 · Cited by 635

Hormone-sensitive Lipase Deficiency in Mice Causes Diglyceride Accumulation in Adipose Tissue, Muscle, and Testis

Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T. M., Wagner, E. F., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110355200 · Cited by 613

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

Holland, W. L., & Summers, S. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0025 · Cited by 604

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 536

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Mihaylova, M. M., Vasquez, D. S., Ravnskjaer, K., Denechaud, P.-D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M., & Shaw, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.03.043 · Cited by 533

Enhanced insulin sensitivity in mice lacking ganglioside GM3

Yamashita, T., Hashiramoto, A., Haluzik, M., Mizukami, H., Beck, S., Norton, A., Kono, M., Tsuji, S., Daniotti, J. L., Werth, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0635898100 · Cited by 531

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

Yang, X., Lü, X., Lombès, M., Rha, G. B., Chi, Y., Guerin, T. M., Smart, E. J., & Liu, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.003 · Cited by 490

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase

Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464

Two pathways for lysophosphatidic acid production

Aoki, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.005 · Cited by 458

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

McGee, S. L., van Denderen, B. J. W., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E., & Hargreaves, M. (2008) · Diabetes · doi:10.2337/db07-0843 · Cited by 455

Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets

Kuerschner, L., Moessinger, C., & Thiele, C. (2008) · Traffic · doi:10.1111/j.1600-0854.2007.00689.x · Cited by 411

Regulation of Insulin Action by Ceramide

Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406499200 · Cited by 410

Dietary fats and membrane function: implications for metabolism and disease

Hulbert, A. J., Turner, N. A., Storlien, L. H., & Else, P. L. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006578 · Cited by 410

Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance

Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance

Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395

The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria

Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805768200 · Cited by 390

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

Reyna, S. M., Ghosh, S., Tantiwong, P., Meka, C. S. R., Eagan, P. A., Jenkinson, C. P., Cersósimo, E., DeFronzo, R. A., Coletta, D. K., Sriwijitkamol, A., et al. (2008) · Diabetes · doi:10.2337/db08-0038 · Cited by 390

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 381

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378

Thermodynamics and Mechanics of Membrane Curvature Generation and Sensing by Proteins and Lipids

Baumgart, T., Capraro, B. R., Zhu, C., & Das, S. L. (2011) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.012809.103450 · Cited by 375

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance

Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363

An update on sphingosine-1-phosphate and other sphingolipid mediators

Fyrst, H., & Saba, J. D. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.392 · Cited by 350

Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

Shi, Y., & Burn, P. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1469 · Cited by 345

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

Ye, J., Doyle, P. J., Iglesias, M. A., Watson, D. G., Cooney, G. J., & Kraegen, E. W. (2001) · Diabetes · doi:10.2337/diabetes.50.2.411 · Cited by 343

OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 335

Glycerolipid Metabolism and Signaling in Health and Disease

Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 331

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706794104 · Cited by 325

Dynamic Activity of Lipid Droplets: Protein Phosphorylation and GTP-Mediated Protein Translocation

Bartz, R., Zehmer, J. K., Zhu, M., Chen, Y., Serrero, G., Zhao, Y., & Liu, P. (2007) · Journal of Proteome Research · doi:10.1021/pr070158j · Cited by 316

Regulation of sphingosine kinase and sphingolipid signaling

Pitson, S. M. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.08.001 · Cited by 314

The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle

Hornberger, T. A., Chu, W. K., Mak, Y. W., Hsiung, J. W., Huang, S. A., & Chien, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600678103 · Cited by 312

Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes

Miyoshi, H., Perfield, J. W., Souza, S. C., Shen, W., Zhang, H., Stancheva, Z. S., Kraemer, F. B., Obin, M. S., & Greenberg, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605770200 · Cited by 305

Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover

Listenberger, L. L., Ostermeyer‐Fay, A. G., Goldberg, E. B., Brown, W. J., & Brown, D. A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700359-jlr200 · Cited by 301

Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

Aerts, J. M. F. G., Ottenhoff, R., Powlson, A., Grefhorst, A., van Eijk, M., Dubbelhuis, P. F., Aten, J., Kuipers, F., Serlie, M. J. M., Wennekes, T., et al. (2007) · Diabetes · doi:10.2337/db06-1619 · Cited by 301

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

Taschler, U., Radner, F. P. W., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Köfeler, H. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215434 · Cited by 294

Ceramide‐rich platforms in transmembrane signaling

Stancevic, B., & Kolesnick, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.026 · Cited by 291

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2 Emission during Long-chain Fatty Acid Oxidation

Seifert, E. L., Estey, C., Xuan, J. Y., & Harper, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026203 · Cited by 289

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity

Samad, F., Hester, K. D., Yang, G., Hannun, Y. A., & Bielawski, J. (2006) · Diabetes · doi:10.2337/db06-0330 · Cited by 285

Effect of 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats

Bergeron, R., Previs, S. F., Cline, G. W., Perret, P., Russell, R. R., Young, L. H., & Shulman, G. I. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1076 · Cited by 285

TIP47 functions in the biogenesis of lipid droplets

Bulankina, A. V., Deggerich, A., Wenzel, D., Mutenda, K. E., Wittmann, J., Rudolph, M. G., Burger, K. N. J., & Höning, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812042 · Cited by 284

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Watt, M. J., Dzamko, N. L., Thomas, W. G., Rose‐John, S., Ernst, M., Carling, D., Kemp, B. E., Febbraio, M. A., & Steinberg, G. R. (2006) · Nature Medicine · doi:10.1038/nm1383 · Cited by 282

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

Wang, H., Bell, M., Sreenevasan, U., Hu, H., Liu, J., Dalen, K. T., Londos, C., Yamaguchi, T., Rizzo, M. A., Coleman, R., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.207779 · Cited by 279

Long-Chain Acyl-Coa Synthetases And Fatty Acid Channeling

Mashek, D. G., Li, L. O., & Coleman, R. (2007) · Future Lipidology · doi:10.2217/17460875.2.4.465 · Cited by 279

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269

Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle

Strączkowski, M., Kowalska, I., Nikołajuk, A., Dzienis-Straczkowska, S., Kinalska, I., Baranowski, M., Żendzian‐Piotrowska, M., Brzezinska, Z., & Górski, J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1215 · Cited by 263

The Effect of Aging on Human Skeletal Muscle Mitochondrial and Intramyocellular Lipid Ultrastructure

Crane, J. D., Devries, M. C., Safdar, A., Hamadeh, M. J., & Tarnopolsky, M. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp179 · Cited by 262

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.006 · Cited by 261

A Novel Function for Fatty Acid Translocase (FAT)/CD36

Campbell, S. E., Tandon, N. N., Woldegiorgis, G., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400566200 · Cited by 259

Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex

Lee, K., Kerner, J., & Hoppel, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228692 · Cited by 254

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18917 · Cited by 254

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245

LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues

Dalen, K. T., Dahl, T. B., Holter, E., Arntsen, B. M., Londos, C., Sztalryd, C., & Nebb, H. I. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.11.011 · Cited by 244

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

Watt, M. J., Holmes, A. G., Pinnamaneni, S. K., GARNHAM, A. P., Steinberg, G. R., Kemp, B. E., & Febbraio, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2005 · Cited by 241

Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes

van Loon, L. J. C., Koopman, R., Manders, R., van der Weegen, W., van Kranenburg, G. P., & Keizer, H. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2003 · Cited by 239

Higher skeletal muscle α2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise

Roepstorff, C., Thiele, M., Hillig, T., Pilegaard, H., Richter, E. A., Wojtaszewski, J. F. P., & Kiens, B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108720 · Cited by 238

Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes

Zhao, H., Przybylska, M., Wu, I., Zhang, J., Siegel, C., Komarnitsky, S., Yew, N. S., & Cheng, S. H. (2007) · Diabetes · doi:10.2337/db06-0719 · Cited by 238

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 236

Adipocyte Protein S3-12 Coats Nascent Lipid Droplets

Wolins, N. E., Skinner, J. R., Schoenfish, M. J., Tzekov, A., Bensch, K. G., & Bickel, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304025200 · Cited by 235

Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

Chibalin, A. V., Leng, Y., Vieira, E., Krook, A., Björnholm, M., Long, Y. C., Kotova, O., Zhong, Z., Sakane, F., Steiler, T., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.035 · Cited by 232

The role of phosphoinositide 3‐kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

O’Neil, T. K., Duffy, L. R., Frey, J. W., & Hornberger, T. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173609 · Cited by 230

Fat content in individual muscle fibers of lean and obese subjects.

Malenfant, P., Joanisse, D., Thériault, R., Goodpaster, B., Kelley, D., & Simoneau, J.-A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801733 · Cited by 227

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

Granneman, J. G., Moore, H. P., Mottillo, E. P., Zhu, Z., & Zhou, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180711 · Cited by 222

Adipose Tissue Expression of the Lipid Droplet–Associating Proteins S3-12 and Perilipin Is Controlled by Peroxisome Proliferator–Activated Receptor-γ

Dalen, K. T., Schoonjans, K., Ulven, S. M., Weedon-Fekjær, M. S., Bentzen, T. G., Koutníková, H., Auwerx, J. H., & Nebb, H. I. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1243 · Cited by 212

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418917 · Cited by 212

Proteome of Skeletal Muscle Lipid Droplet Reveals Association with Mitochondria and Apolipoprotein A-I

Zhang, H., Wang, Y., Li, J., Yu, J., Pu, J., Li, L., Zhang, H., Zhang, S., Gong, P., Yang, F., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200553c · Cited by 211

Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells

JeBailey, L., Wanono, O., Niu, W., Roessler, J., Rudich, A., & Klip, A. (2007) · Diabetes · doi:10.2337/db06-0823 · Cited by 211

Ceramide and ceramide 1-phosphate in health and disease

Arana, L., Gangoiti, P., Ouro, A., Trueba, M., & Gómez‐Muñoz, A. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-15 · Cited by 209

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL

Gaidhu, M. P., Fediuc, S., Anthony, N. M., So, M., Mirpourian, M., Perry, R. L. S., & Ceddia, R. B. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800480-jlr200 · Cited by 203

Long-term synaptic changes induced in the cerebellar cortex by fear conditioning.

Sacchetti, B., Scelfo, B., Tempia, F., & Strata, P. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.012 · Cited by 201

Greater Transport Efficiencies of the Membrane Fatty Acid Transporters FAT/CD36 and FATP4 Compared with FABPpm and FATP1 and Differential Effects on Fatty Acid Esterification and Oxidation in Rat Skeletal Muscle

Nickerson, J. G., Alkhateeb, H. H., Benton, C. R., Lally, J., Nickerson, J., Han, X.-X., Wilson, M. H., Jain, S. S., Snook, L. A., Glatz, J. F. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004788 · Cited by 197

Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane‐Associated Protein That Resides on Hepatic Lipid Droplets

Turró, S., Ingelmo‐Torres, M., Estanyol, J. M., Tebar, F., Fernandez-Rojo, M. A., Albor, C. V., Gaus, K., Grewal, T., Enrich, C., & Pol, A. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00465.x · Cited by 193

Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet

Mashek, D. G., Li, L. O., & Coleman, R. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600150-jlr200 · Cited by 192

Regulation of LPA-Promoted Myofibroblast Contraction: Role of Rho, Myosin Light Chain Kinase, and Myosin Light Chain Phosphatase

Parizi, M., Howard, E. W., & Tomasek, J. J. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4754 · Cited by 188

Perilipins Are Associated with Cholesteryl Ester Droplets in Steroidogenic Adrenal Cortical and Leydig Cells

Servetnick, D. A., Brasaemle, D., Gruia-Gray, J., Kimmel, A. R., Wolff, J., & Londos, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16970 · Cited by 187

Functional differences in lipid metabolism in resting skeletal muscle of various fiber types

Dyck, D. J., Peters, S. J., Glatz, J. F. C., Górski, J., KEIZER, H. A., Kiens, B., Liu, S., Richter, E. A., Spriet, L. L., Vusse, G. J., et al. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.3.e340 · Cited by 186

Lipins: Multifunctional Lipid Metabolism Proteins

Csaki, L. S., & Reue, K. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104729 · Cited by 173

Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins

Wang, H., Hu, L., Dalen, K. T., Dorward, H. M., Marcinkiewicz, A., Russell, D. L., Gong, D., Londos, C., Yamaguchi, T., Holm, C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006726 · Cited by 167

Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets

Putman, C. T., Spriet, L. L., Hultman, E., Lindinger, M. I., Lands, L. C., McKelvie, R. S., Cederblad, G., Jones, N. L., & Heigenhauser, G. J. F. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.5.e752 · Cited by 166

Regulation and function of triacylglycerol lipases in cellular metabolism

Watt, M. J., & Steinberg, G. R. (2008) · Biochemical Journal · doi:10.1042/bj20080305 · Cited by 165

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F. W., Taylor, R. J., & Carr, M. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210693 · Cited by 163

Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation

Perdomo, G., Commerford, S. R., Richard, A.-M. T., Adams, S. H., Corkey, B. E., O'Doherty, R. M., & Brown, N. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403566200 · Cited by 158

Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling

Nagata, Y., Partridge, T. A., Matsuda, R., & Zammit, P. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605028 · Cited by 153

Effects of Weight Loss and Physical Activity on Muscle Lipid Content and Droplet Size

He, J., Goodpaster, B. H., & Kelley, D. E. (2004) · Obesity Research · doi:10.1038/oby.2004.92 · Cited by 152

Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration

Anderson, E. J., Yamazaki, H., & Neufer, P. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706129200 · Cited by 151

Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum

McFie, P. J., Banman, S. L., Kary, S., & Stone, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256008 · Cited by 149

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

Huijsman, E., van de Par, C., Economou, C., van der Poel, C., Lynch, G. S., Schoiswohl, G., Haemmerle, G., Zechner, R., & Watt, M. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2009 · Cited by 145

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

Benton, C. R., Holloway, G. P., Han, X.-X., Yoshida, Y., Snook, L. A., Lally, J., Glatz, J. F. C., Luiken, J. J. F. P., Chabowski, A., & Bonen, A. (2010) · Diabetologia · doi:10.1007/s00125-010-1773-1 · Cited by 144

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

Gangoiti, P., Camacho, L., Arana, L., Ouro, A., Granado, M. H., Brizuela, L., Casas, J., Fabriàs, G., Abad, J. L., Delgado, A., et al. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.02.004 · Cited by 143

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

Joseph, C. K., Wright, S. D., BORNMANN, W. G., Randolph, J. T., Kumar, E. R., Bittman, R., Liu, J., & Kolesnick, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32484-5 · Cited by 142

Network distribution of mitochondria and lipid droplets in human muscle fibres

Shaw, C. S., Jones, D. A., & Wagenmakers, A. J. M. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0349-8 · Cited by 140

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

Sebastián, D., Guitart, M., Garcia‐Martínez, C., Mauvezin, C., Orellana‐Gavaldà, J. M., Serra, D., Gómez-Foix, A. M., Hegardt, F. G., & Asins, G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800535-jlr200 · Cited by 139

Functional Interactions between Mldp (LSDP5) and Abhd5 in the Control of Intracellular Lipid Accumulation

Granneman, J. G., Moore, H. H., Mottillo, E. P., & Zhu, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808251200 · Cited by 139

Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1

Gobeil, F., Bernier, S. G., Vazquez‐Tello, A., Brault, S., Beauchamp, M., Quiniou, C., Marrache, A. M., Checchin, D., Sennlaub, F., Hou, X., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212481200 · Cited by 137

Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4

Fischer, H., Ellström, P., Ekström, K., Gustafsson, L., Gustafsson, M. C. U., & Svanborg, C. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00867.x · Cited by 136

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

Badin, P.-M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D., & Moro, C. (2011) · Diabetes · doi:10.2337/db10-1364 · Cited by 132

Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase

Borg, M. L., Andrews, Z. B., Duh, E. J., Zechner, R., Meikle, P. J., & Watt, M. J. (2011) · Diabetes · doi:10.2337/db10-0845 · Cited by 131

Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance

Turban, S., & Hajduch, É. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.022 · Cited by 124

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Vaag, A., Skött, P., Damsbo, P., Gall, M. A., Richter, E. A., & Beck-Nielsen, H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115432 · Cited by 123

Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise

Roepstorff, C., Donsmark, M., Thiele, M., Vistisen, B., Stewart, G., Vissing, K., Schjerling, P., Hardie, D. G., Galbo, H., & Kiens, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00097.2006 · Cited by 118

Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Promotes Skeletal Muscle Lipid Refueling in Vivo by Activating de Novo Lipogenesis and the Pentose Phosphate Pathway*

Summermatter, S., Baum, O., Santos, G., Hoppeler, H. H., & Handschin, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145995 · Cited by 115

Sphingosine 1‐phosphate regulates myogenic differentiation: a major role for S1P 2 receptor

Donati, C., Meacci, E., Nuti, F., Becciolini, L., Farnararo, M., & Bruni, P. (2004) · The FASEB Journal · doi:10.1096/fj.04-1780fje · Cited by 115

LIPID SYNTHESIS, INTRACELLULAR TRANSPORT, AND STORAGE

Stein, O., & Stein, Y. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.36.1.63 · Cited by 114

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

Blouin, C. M., Prado, C., Takane, K. K., Lasnier, F., Garcı́a-Ocaña, A., Ferré, P., Dugail, I., & Hajduch, É. (2009) · Diabetes · doi:10.2337/db09-0897 · Cited by 114

Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation.

Egan, J. J., Greenberg, A. S., Chang, M. K., & Londos, C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30578-1 · Cited by 113

Gastric Bypass Surgery Reduces Plasma Ceramide Subspecies and Improves Insulin Sensitivity in Severely Obese Patients

Huang, H., Kasumov, T., Gatmaitan, P., Heneghan, H., Kashyap, S. R., Schauer, P. R., Brethauer, S. A., & Kirwan, J. P. (2011) · Obesity · doi:10.1038/oby.2011.107 · Cited by 113

Inhibition of ADRP prevents diet-induced insulin resistance

Varela, G. M., Antwi, D. A., Dhir, R. N., Yin, X., Singhal, N. S., Graham, M. J., Crooke, R. M., & Ahima, R. S. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90204.2008 · Cited by 113

The effects of sphingosine on sarcoplasmic reticulum membrane calcium release.

Sabbadini, R. A., Betto, R., Teresi, A., Fachechi-Cassano, G., & Salviati, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49559-8 · Cited by 110

Kinetics of intramuscular triglyceride fatty acids in exercising humans

Guo, Z., Burguera, B., & Jensen, M. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2057 · Cited by 110

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

Boon, H., Bosselaar, M., Praet, S., Blaak, E. E., Saris, W. H. M., Wagenmakers, A. J. M., McGee, S. L., Tack, C. J., Smits, P., Hargreaves, M., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1108-7 · Cited by 108

Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation

Formigli, L., Sassoli, C., Squecco, R., Bini, F., Martinesi, M., Chellini, F., Luciani, G., Sbrana, F., Zecchi‐Orlandini, S., Francini, F., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.035402 · Cited by 108

Fatty acids as substrates for heart and skeletal muscle.

Zierler, K. L. (1976) · Circulation Research · doi:10.1161/01.res.38.6.459 · Cited by 108

Activation of the Drosophila MLK by Ceramide Reveals TNF-α and Ceramide as Agonists of Mammalian MLK3

Sathyanarayana, P., Barthwal, M. K., Kundu, C. N., Lane, M. E., Bergmann, A., Tzivion, G., & Rana, A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00734-7 · Cited by 107

Sphingolipid Metabolism, Oxidant Signaling, and Contractile Function of Skeletal Muscle

Nikolova‐Karakashian, M., & Reid, M. B. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3940 · Cited by 106

Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

Prats, C., Donsmark, M., Qvortrup, K., Londos, C., Sztalryd, C., Holm, C., Galbo, H., & Ploug, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600247-jlr200 · Cited by 105

Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle

Dyck, D. J., Steinberg, G. R., & Bonen, A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e600 · Cited by 105

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104

FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation

Smith, B. K., Jain, S., Rimbaud, S., Dam, A. D., Quadrilatero, J., Ventura‐Clapier, R., Bonen, A., & Holloway, G. P. (2011) · Biochemical Journal · doi:10.1042/bj20101861 · Cited by 104

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., Lorenzi, R. D., Krone, W., Rajewsky, K., & Brüning, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18712 · Cited by 103

Roles of peroxisome proliferator-activated receptor delta (PPARδ) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome

Luquet, S. H., López‐Soriano, J., Holst, D., Gaudel, C., Jehl-Piétri, C., Fredenrich, A., & Grimaldi, P. A. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.024 · Cited by 98

From Dynamic Live Cell Imaging to 3D Ultrastructure: Novel Integrated Methods for High Pressure Freezing and Correlative Light-Electron Microscopy

Spiegelhalter, C., Tosch, V., Hentsch, D., Koch, M., Kessler, P., Schwab, Y., & Laporte, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009014 · Cited by 95

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

Watson, M., Coghlan, M. P., & Hundal, H. S. (2008) · Biochemical Journal · doi:10.1042/bj20081149 · Cited by 95

Relationship between plasma free fatty acid, intramyocellular triglycerides and long‐chain acylcarnitines in resting humans

Kanaley, J. A., Shadid, S., Sheehan, M. T., Guo, Z., & Jensen, M. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180695 · Cited by 92

Ciliary Neurotrophic Factor Prevents Acute Lipid-Induced Insulin Resistance by Attenuating Ceramide Accumulation and Phosphorylation of c-Jun N-Terminal Kinase in Peripheral Tissues

Watt, M. J., Hevener, A. L., Lancaster, G. I., & Febbraio, M. A. (2006) · Endocrinology · doi:10.1210/en.2005-1074 · Cited by 92

Muscle contraction increases palmitate esterification and oxidation and triacylglycerol oxidation

Dyck, D. J., & Bonen, A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e888 · Cited by 89

Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR‐induced AMPK Activation

Anthony, N. M., Gaidhu, M. P., & Ceddia, R. B. (2009) · Obesity · doi:10.1038/oby.2008.645 · Cited by 89

Lipid Partitioning, Incomplete Fatty Acid Oxidation, and Insulin Signal Transduction in Primary Human Muscle Cells: Effects of Severe Obesity, Fatty Acid Incubation, and Fatty Acid Translocase/CD36 Overexpression

Bell, J. A., Reed, M. A., Consitt, L. A., Martin, O. J., Haynie, K. R., Hulver, M. W., Muoio, D. M., & Dohm, G. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1596 · Cited by 88

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

Hu, W. M., Bielawski, J., Samad, F., Merrill, A. H., & Cowart, L. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800635-jlr200 · Cited by 87

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00311.2006 · Cited by 87

IMCL area density, but not IMCL utilization, is higher in women during moderate-intensity endurance exercise, compared with men

Devries, M. C., Lowther, S. A., Glover, A. W., Hamadeh, M. J., & Tarnopolsky, M. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00510.2007 · Cited by 87

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor

Rapizzi, E., Taddei, M. L., Fiaschi, T., Donati, C., Bruni, P., & Chiarugi, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0106-3 · Cited by 84

FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells

Hatch, G. M., Smith, A. J., Xu, F. Y., Hall, A. M., & Bernlohr, D. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200130-jlr200 · Cited by 83

Extracellular Signal-Regulated Kinase-1 and -2 Respond Differently to Mitogenic and Differentiative Signaling Pathways in Myoblasts

Sarbassov, D. D., Jones, L. G., & Peterson, C. A. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0036 · Cited by 82

FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle

Holloway, G. P., Jain, S., Bézaire, V., Han, X. X., Glatz, J. F. C., Luiken, J. J. F. P., Harper, M., & Bonen, A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91021.2008 · Cited by 81

Intramuscular fatty acid metabolism in contracting and non‐contracting human skeletal muscle

Sacchetti, M., Saltin, B., Osada, T., & van Hall, G. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013912 · Cited by 81

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

Röhl, M., Pasparakis, M., Baudler, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418712 · Cited by 81

Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance

Kim, H. J., Lee, J. S., & Kim, C. K. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1214-2 · Cited by 79

Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training

Malenfant, P., Tremblay, A., Doucet, É., Imbeault, P., Simoneau, J., & Joanisse, D. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.4.e632 · Cited by 78

Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle

Watt, M. J., Heigenhauser, G. J. F., & Spriet, L. L. (2002) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00301.x · Cited by 77

Chronic hyperglycaemia promotes lipogenesis and triacylglycerol accumulation in human skeletal muscle cells

Aas, V., Kase, E. T., Solberg, R., Jensen, J., & Rustan, A. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1465-9 · Cited by 75

Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation

Kaiser, C., & James, S. R. (2004) · BMC Biology · doi:10.1186/1741-7007-2-23 · Cited by 74

Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts

Gangoiti, P., Bernacchioni, C., Donati, C., Cencetti, F., Ouro, A., Gómez‐Muñoz, A., & Bruni, P. (2011) · Biochimie · doi:10.1016/j.biochi.2011.09.009 · Cited by 73

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation

Wensaas, A. J., Rustan, A. C., Just, M., Berge, R. K., Drevon, C. A., & Gaster, M. (2009) · Diabetes · doi:10.2337/db08-1043 · Cited by 73

Effects of epinephrine on lipid metabolism in resting skeletal muscle

Peters, S. J., Dyck, D. J., Bonen, A., & Spriet, L. L. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e300 · Cited by 72

Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance

Han, D.-H., Hancock, C. R., Jung, S. R., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019739 · Cited by 71

Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase

Bourron, O., Daval, M., Hainault, I., Hajduch, É., Servant, J. M., Gautier, J. F., Ferré, P., & Foufelle, F. (2009) · Diabetologia · doi:10.1007/s00125-009-1639-6 · Cited by 69

Pleiotropic effects of sphingolipids in skeletal muscle

Bruni, P., & Donati, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8236-6 · Cited by 68

Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle

Watt, M. J., Heigenhauser, G. J. F., & Spriet, L. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034595 · Cited by 64

Transgenic mice with dominant negative PKC‐theta in skeletal muscle: A new model of insulin resistance and obesity

Serra, C., Federici, M., Buongiorno, A. M., Senni, M., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10278 · Cited by 62

Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle

Shaw, C. S., Sherlock, M., Stewart, P. M., & Wagenmakers, A. J. M. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0558-4 · Cited by 59

Exercise increases plasma levels of sphingoid base‐1 phosphates in humans

Baranowski, M., Charmas, M., Długołęcka, B., & Górski, J. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02322.x · Cited by 58

Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin

Badimón, L., Rodrı́guez, C., González-Díez, M., & Martínez‐González, J. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-10-0675 · Cited by 56

Long‐chain fatty acid uptake by skeletal muscle is impaired in homozygous, but not heterozygous, heart‐type‐FABP null mice

Luiken, J. J. F. P., Koonen, D. P. Y., Coumans, W. A., Pelsers, M. M. A. L., Binas, B., Bonen, A., & Glatz, J. F. C. (2003) · Lipids · doi:10.1007/s11745-003-1089-6 · Cited by 54

Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake

Yea, K., Kim, J. J., Lim, S., Park, H. S., Park, K. S., Suh, P., & Ryu, S. H. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0269-z · Cited by 52

High triacylglycerol turnover rate in human skeletal muscle

Sacchetti, M., Saltin, B., Olsen, D. B., & van Hall, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.075135 · Cited by 50

Local factors modulate tissue-specific NEFA utilization: assessment in rats using 3H-(R)-2-bromopalmitate.

Furler, S. M., Cooney, G. J., Hegarty, B. D., Lim-Fraser, M., Kraegen, E. W., & Oakes, N. D. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1427 · Cited by 49

Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors

Meacci, E., Cencetti, F., Formigli, L., Squecco, R., Donati, C., Tiribilli, B., Quercioli, F., Orlandini, S. Z., Francini, F., & Bruni, P. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620349 · Cited by 48

Sphingolipids: the nexus between Gaucher disease and insulin resistance

Fuller, M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-113 · Cited by 48

Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis

Meacci, E., Bini, F., Sassoli, C., Martinesi, M., Squecco, R., Chellini, F., Zecchi‐Orlandini, S., Francini, F., & Formigli, L. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0442-3 · Cited by 45

Lysophosphatidic acid mediates pleiotropic responses in skeletal muscle cells

Jean-Baptiste, G., Yang, Z., Khoury, C., & Greenwood, M. T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.011 · Cited by 43

Trafficking of Dietary Fat in Lean Rats

Bessesen, D. H., Rupp, C. L., & Eckel, R. H. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00135.x · Cited by 42

Permissive role of protein kinase Cα but not protein kinase Cδ in sphingosine 1‐phosphate‐induced RhoA activation in C2C12 myoblasts

Meacci, E., Donati, C., Cencetti, F., Romiti, E., & Bruni, P. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02039-1 · Cited by 40

mTOR function in skeletal muscle: a focal point for overnutrition and exercise

Rivas, D. A., Lessard, S. J., & Coffey, V. G. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-073 · Cited by 39

FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C2C12muscle cells

Digel, M., Staffer, S., Ehehalt, F., Stremmel, W., Ehehalt, R., & Füllekrug, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00079.2011 · Cited by 37

Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles

Błachnio-Zabielska, A. U., Baranowski, M., Zabielski, P., & Górski, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21877 · Cited by 35

FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria

Jeppesen, J. F., Mogensen, M., Prats, C., Sahlin, K., Madsen, K., & Kiens, B. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m003756 · Cited by 33

Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise

Shearer, J., Fueger, P. T., Rottman, J. N., Bracy, D. P., Binas, B., & Wasserman, D. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2004 · Cited by 32

Adipophilin protein expression in muscle – a possible protective role against insulin resistance

de Wilde, J., Smit, E., Snepvangers, F. J. M., de Wit, N. J. W., Mohren, R., Hulshof, M. F. M., & Mariman, E. C. M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07525.x · Cited by 31

Effect of Acute Exercise on the Content of Free Sphinganine and Sphingosine in Different Skeletal Muscle Types of the Rat

Dobrzyń, A., & Górski, J. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-34793 · Cited by 31

Long-Chain Fatty Acid Combustion Rate Is Associated with Unique Metabolite Profiles in Skeletal Muscle Mitochondria

Seifert, E. L., Fiehn, O., Bézaire, V., Bickel, D. R., Wohlgemuth, G., Adams, S. H., & Harper, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009834 · Cited by 30

Mechanisms of the lysophosphatidic acid‐induced increase in [Ca2+]iin skeletal muscle cells

Xu, Y., Tappia, P. S., Goyal, R. K., & Dhalla, N. S. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00139.x · Cited by 29

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Kalucka, J. M., de Rooij, L. P. M. H., Goveia, J., Rohlenová, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L.-A. M. N., Veys, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.015 · Cited by 1,356

Sugar consumption, metabolic disease and obesity: The state of the controversy

Stanhope, K. L. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1084990 · Cited by 739

Lipids, lysosomes, and autophagy

Jaishy, B. P., & Abel, E. D. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r067520 · Cited by 239

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

Turner, N. A., Cooney, G. J., Kraegen, E. W., & Bruce, C. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 206

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction

Nishi, H., Higashihara, T., & Inagi, R. (2019) · Nutrients · doi:10.3390/nu11071664 · Cited by 179

REVIEWS Intracellular Signal for Skeletal Muscle Adaptation Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

Watt, M. J., & Hoy, A. J. (2012)

Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle

Park, S. S., & Seo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061949 · Cited by 111

Skeletal muscle lipid metabolism and the adipomuscular axis

Sugden, M. C., & Holness, M. J. (2006) · Future Lipidology · doi:10.2217/17460875.1.2.153 · Cited by 7

Lipid metabolic features of skeletal muscle in pathological and physiological conditions

Son, Y., & Paton, C. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00018-x · Cited by 7

Free fatty acids and skeletal muscle insulin resistance

Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 210