Cited by 142Lipid metabolism and biosynthesisAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

Watt, Matthew J., Hoy, Andrew J.·2012·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00561.2011

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Abstract

Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or de novo lipogenesis serve a variety of functions in skeletal muscle. The two major fates of fatty acids are mitochondrial oxidation to provide energy for the myocyte and storage within a variety of lipids, where they are stored primarily in discrete lipid droplets or serve as important structural components of membranes. In this review, we provide a brief overview of skeletal muscle fatty acid metabolism and highlight recent notable advances in the field. We then 1) discuss how lipids are stored in and mobilized from various subcellular locations to provide adaptive or maladaptive signals in the myocyte and 2) outline how lipid metabolites or metabolic byproducts derived from the actions of triacylglycerol metabolism or β-oxidation act as positive and negative regulators of insulin action. We have placed an emphasis on recent developments in the lipid biology field with respect to understanding skeletal muscle physiology and discuss unanswered questions and technical limitations for assessing lipid signaling in skeletal muscle.

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Authors: Watt, M. J., & Hoy, A. J.
Affiliations: Monash University (AU)
Corresponding author: Watt, Matthew J.
ORCID: Watt, Matthew J.
Hoy, Andrew J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2012-06-01
Volume: 302
Issue: 11
Pages: E1315-E1328
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00561.2011
OpenAlex: W2033804400
Cited by: 142
References: 208
Citations by year: 2026: 5 · 2025: 13 · 2024: 15 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 7
FWCI: 0.88
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: skeletal muscle lipid metabolism, fatty acid metabolism, lipolysis, de novo lipogenesis, lipid droplets, mitochondrial fatty acid oxidation, fatty acid beta-oxidation, lipid signaling, insulin action, adipose tissue lipolysis, membrane lipids
MeSH terms: Adaptation, Physiological, Animals, Fatty Acids, Humans, Insulin Resistance, Lipids, Triglycerides, Signal Transduction, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism

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Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

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