Cited by 1,013Metabolism, Diabetes, and CancerIon Transport and Channel RegulationCancer, Hypoxia, and Metabolism

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Glucose transporters in the 21st Century

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Thorens, Bernard, Mueckler, Mike·2010·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00712.2009PMC PMC2822486

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Abstract

The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1–4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area.

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Authors: Thorens, B., & Mueckler, M.
Affiliations: University of Lausanne (CH)
Washington University in St. Louis (US)
Corresponding author: Mueckler, Mike
ORCID: Thorens, Bernard
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2010-02
Volume: 298
Issue: 2
Pages: E141-E145
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00712.2009
PMC: PMC2822486
OpenAlex: W2112331117
Cited by: 1,013
References: 51
Citations by year: 2026: 36 · 2025: 57 · 2024: 87 · 2023: 74 · 2022: 70 · 2021: 76 · 2020: 80 · 2019: 62 · 2018: 94 · 2017: 59 · 2016: 58 · 2015: 63 · 2014: 63 · 2013: 43 · 2012: 61
FWCI: 2.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: U.S. Public Health Service (R0143695)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: glucose transporters, GLUT family, glucose homeostasis, fructose transport, urate transport, membrane transporters
MeSH terms: Glucose, Humans, Membrane Transport Proteins, Glucose Transport Proteins, Facilitative

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Glucose transporters in the 21st Century

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