The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Glucose transporters in the 21st Century
Open accessAbstract
The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1–4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In particular, insulin facilitates the translocation of GLUT1, GLUT3 and GLUT4 from intracellular pools to the cell membrane to amplify the glucose uptake in adipocytes and muscle cells, while GCs antagonize this process by translocating GLUTs from the cell membrane back to intracellular compartments (26, 27).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In pancreatic beta cells, GLUT1, GLUT2 and GLUT3 are involved in glucose sensing and possess different affinities for extracellular glucose compared to those in fat and muscle cells (26, 28).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“GLUTs are also involved in glucose sensing in pancreatic beta cells, with the caveat that the GLUT isoforms present in these insulin-secreting cells possess a different glucose sensitivity threshold than those in fat and muscle cells ( 28-31 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,467
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Sequence and Structure of a Human Glucose Transporter
Mueckler, M. M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I., Morris, H. R., Allard, W. J., Lienhard, G. E., & Lodish, H. F. (1985) · Science · doi:10.1126/science.3839598 · Cited by 1,529
Self-citationStructure and Mechanism of the Lactose Permease of Escherichia coli
Abramson, J., Smirnova, I., Kasho, V. N., Verner, G., Kaback, H. R., & Iwata, S. (2003) · Science · doi:10.1126/science.1088196 · Cited by 1,389
Postic, C., & Girard, J. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,243
Hallcher, L. M., & Sherman, W. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70391-3 · Cited by 1,098
Cushman, S. W., & Wardzala, L. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85561-8 · Cited by 1,088
Suzuki, K. T., & Kôno, T. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2542 · Cited by 1,030
Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli
Huang, Y., Lemieux, M. J., Song, J., Auer, M., & Wang, D. (2003) · Science · doi:10.1126/science.1087619 · Cited by 1,015
Research works printed but not linked: 1
- Wardzala LJ, 1981, J Biol Chem, 253, 4758
Cited by
Sorted by citations
The PI3K/AKT Pathway in Obesity and Type 2 Diabetes
Huang, X., Liu, G., Guo, J., & Su, Z. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27173 · Cited by 1,673
“AKT directly phosphorylates AS160, inducing GLUT4 translocation, which translocated to the plasma membrane from storage vesicles and transports glucose in skeletal muscle following stimulation of insulin and AKT [38, 39].”
BackgroundThe SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Self-citationGodoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Macintyre, A. N., Gerriets, V. A., Nichols, A., Michalek, R. D., Rudolph, M. C., Deoliveira, D., Anderson, S. M., Abel, E. D., Chen, B. J., Hale, L. P., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.004 · Cited by 1,169
Nutrient-sensing mechanisms and pathways
Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110
Regulation of glucose transport by insulin: traffic control of GLUT4
Leto, D., & Saltiel, A. R. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3351 · Cited by 848
Crystal structure of the human glucose transporter GLUT1
Deng, D., Xu, C., Sun, P., Wu, J., Yan, C., Hu, M., & Yan, N. (2014) · Nature · doi:10.1038/nature13306 · Cited by 777
GLUT2, glucose sensing and glucose homeostasis
Thorens, B. (2015) · Diabetologia · doi:10.1007/s00125-014-3451-1 · Cited by 722
Self-citationGlycogen and its metabolism: some new developments and old themes
Roach, P. J., DePaoli-Roach, A. A., Hurley, T. D., & Tagliabracci, V. S. (2012) · Biochemical Journal · doi:10.1042/bj20111416 · Cited by 728
Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Kenny, R. G., & Marmion, C. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00271 · Cited by 636
Targeting immunometabolism as an anti-inflammatory strategy
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2020) · Cell Research · doi:10.1038/s41422-020-0291-z · Cited by 590
Metabolic Signaling in Fuel-Induced Insulin Secretion
Prentki, M., Matschinsky, F. M., & Madiraju, S. R. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.018 · Cited by 548
Glucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558
Chen, L.-Q., Cheung, L. S., Feng, L., Tanner, W., & Frommer, W. B. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033904 · Cited by 507
Exercise-stimulated glucose uptake — regulation and implications for glycaemic control
Sylow, L., Kleinert, M., Richter, E. A., & Jensen, T. E. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.162 · Cited by 498
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
Merz, K. E., & Thurmond, D. C. (2020) · Comprehensive Physiology · doi:10.1002/cphy.c190029 · Cited by 494
Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz‐Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 523
Crystal structure of a bacterial homologue of glucose transporters GLUT1–4
Sun, L., Zeng, X. W., Yan, C., Sun, X., Gong, X., Rao, Y., & Yan, N. (2012) · Nature · doi:10.1038/nature11524 · Cited by 483
Fruit and vegetable waste management: Conventional and emerging approaches
Esparza, I., Jiménez-Moreno, N., Bimbela, F., Ancín-Azpilicueta, C., & Gandía, L. M. (2020) · Journal of Environmental Management · doi:10.1016/j.jenvman.2020.110510 · Cited by 467
Expression of glucose transporters in cancers
Szablewski, L. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.12.004 · Cited by 453
Structural Biology of the Major Facilitator Superfamily Transporters
Yan, N. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-033901 · Cited by 467
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment
Barron, C. C., Bilan, P. J., Tsakiridis, T. K., & Tsiani, E. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.007 · Cited by 450
Mannose impairs tumour growth and enhances chemotherapy
Gonzalez, P. S., O’Prey, J., Cardaci, S., Barthet, V. J. A., Sakamaki, J.-I., Beaumatin, F., Roseweir, A. K., Gay, D. M., Mackay, G., Malviya, G., et al. (2018) · Nature · doi:10.1038/s41586-018-0729-3 · Cited by 430
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 484
Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
Tahrani, A. A., Barnett, A. H., & Bailey, C. J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.86 · Cited by 398
Molecular basis of ligand recognition and transport by glucose transporters
Deng, D., Sun, P., Yan, C., Ke, M., Jiang, X. J., Xiong, L., Ren, W., Hirata, K., Yamamoto, M., Fan, S., et al. (2015) · Nature · doi:10.1038/nature14655 · Cited by 397
Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery
Patching, S. G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9672-6 · Cited by 376
Update on developments with SGLT2 inhibitors in the management of type 2 diabetes
Nauck, M. (2014) · Drug Design, Development and Therapy · doi:10.2147/dddt.s50773 · Cited by 343
Insulin: The master regulator of glucose metabolism
Norton, L., Shannon, C. E., Gastaldelli, A., & DeFronzo, R. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155142 · Cited by 367
Emerging Roles of Vascular Endothelium in Metabolic Homeostasis
Pi, X., Xie, L., & Patterson, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.313237 · Cited by 304
The Warburg effect and drug resistance
Bhattacharya, B., Omar, M. F. M., & Soong, R. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13422 · Cited by 303
The role of glucose transporters in brain disease: Diabetes and Alzheimer’s disease
Shah, K., DeSilva, S., & Abbruscato, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012629 · Cited by 288
Wu, L., Jin, Y., Zhao, X., Tang, K., Zhao, Y., Tong, L., Yu, X., Xiong, K., Luo, C., Zhu, J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.001 · Cited by 301
Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
Krześlak, A., Wójcik‐Krowiranda, K., Forma, E., Jóźwiak, P., Romanowicz, H., Bieńkiewicz, A., & Bryś, M. (2012) · Pathology & Oncology Research · doi:10.1007/s12253-012-9500-5 · Cited by 280
Regulation of Glucose Transporter Translocation in Health and Diabetes
Bogan, J. S. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060109-094246 · Cited by 279
GLUT , SGLT , and SWEET : Structural and mechanistic investigations of the glucose transporters
Deng, D., & Yan, N. (2015) · Protein Science · doi:10.1002/pro.2858 · Cited by 285
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 299
Song, X., Liu, J., Kuang, F., Chen, X., Zeh, H. J., Kang, R., Kroemer, G., Xie, Y., & Tang, D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108767 · Cited by 262
Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview
Naik, L. C. P. (2014) · Journal of Pharmacovigilance · doi:10.4172/2329-6887.1000125 · Cited by 272
Fructose induced lipogenesis: from sugar to fat to insulin resistance
Samuel, V. T. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.10.003 · Cited by 271
Solute carrier transporters: the metabolic gatekeepers of immune cells
Song, W., Li, D., Tao, L., Luo, Q., & Chen, L. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.006 · Cited by 264
Herman, R., Kravos, N. A., Jensterle, M., Janež, A., & Dolžan, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031264 · Cited by 282
DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
Zhang, Z., Li, X., Yang, F., Chen, C., Liu, P., Ren, Y., Sun, P., Wang, Z., You, Y., Zeng, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26180-4 · Cited by 249
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
Kasprzak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126434 · Cited by 248
Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs
Shi, L., Salamon, H., Eugenín, E. A., Pine, R. I., Cooper, A. M., & Gennaro, M. L. (2015) · Scientific Reports · doi:10.1038/srep18176 · Cited by 241
Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
Gantt, R. W., Peltier, P., & Thorson, J. S. (2011) · Natural Product Reports · doi:10.1039/c1np00045d · Cited by 247
Glucose Transporters in Cardiac Metabolism and Hypertrophy
Shao, D., & Tian, R. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150016 · Cited by 290
Ito, K., Uchida, Y., Ohtsuki, S., Aizawa, S., Kawakami, H., Katsukura, Y., Kamiie, J., & Terasaki, T. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22487 · Cited by 231
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker
Carvalho, K. C., da Cunha, I. W., Rocha, R. M., Ayala, F. R. R., Cajaiba, M. M., Begnami, M. D., VILELA, R. S., Paiva, G. R., Andrade, R. G., & Soares, F. A. (2011) · Clinics · doi:10.1590/s1807-59322011000600008 · Cited by 230
Protective Factors and the Pathogenesis of Complications in Diabetes
Yu, M. G., Gordin, D., Fu, J., Park, K., Li, Q., & King, G. L. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad030 · Cited by 252
Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy
Zambrano, Á., Molt, M., Uribe, E. A., & Salas, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133374 · Cited by 220
Zhang, Y., Nakano, D., Guan, Y., Hitomi, H., Uemura, A., Masaki, T., Kobara, H., Sugaya, T., & Nishiyama, A. (2018) · Kidney International · doi:10.1016/j.kint.2018.05.002 · Cited by 203
Roles of microRNA on cancer cell metabolism
Chen, B., Li, H., Zeng, X., Yang, P., Liu, X., Zhao, X., & Liang, S. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-228 · Cited by 206
SLC transporters: structure, function, and drug discovery
Colas, C., Ung, P. M. U., & Schlessinger, A. (2016) · MedChemComm · doi:10.1039/c6md00005c · Cited by 212
Glucose Transporters as a Target for Anticancer Therapy
Pliszka, M., & Szablewski, L. (2021) · Cancers · doi:10.3390/cancers13164184 · Cited by 214
Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203
Hepatic expression and cellular distribution of the glucose transporter family
Karim, S. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6771 · Cited by 190
The role of fructose transporters in diseases linked to excessive fructose intake
Douard, V., & Ferraris, R. P. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.215731 · Cited by 191
Protein palmitoylation in cancer: molecular functions and therapeutic potential
Zhou, B., Hao, Q., Liang, Y., & Kong, E. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13308 · Cited by 190
IGF-1 regulation of key signaling pathways in bone
Guntur, A. R., & Rosen, C. J. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.171 · Cited by 184
The mechanism of Warburg effect-induced chemoresistance in cancer
Liu, C., Jin, Y., & Fan, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698023 · Cited by 177
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174
Intestinal organoids for assessing nutrient transport, sensing and incretin secretion
Zietek, T., Rath, E., Haller, D., & Daniel, H. (2015) · Scientific Reports · doi:10.1038/srep16831 · Cited by 172
Zhang, Z., Zi, Z., Lee, E. E., Zhao, J., Contreras, D. C., South, A. P., Abel, E. D., Chong, B. F., Vandergriff, T. W., Hosler, G. A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0003-0 · Cited by 180
Measurement of Glucose Uptake in Cultured Cells
Yamamoto, N., Wakagi, M., Sato, T., Kawasaki, K., Sawada, K., Kawabata, K., Akagawa, M., & Ashida, H. (2015) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph1214s71 · Cited by 163
Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
He, X., Gong, W., Zhang, J., Nie, J., Yao, C.-F., Guo, F., Lin, Y., Wu, X., Li, F., Li, J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.015 · Cited by 166
Masin, M., Vázquez, J., Rossi, S., Groeneveld, S., Samson, N., Schwalie, P. C., Deplancke, B., Frawley, L. E., Gouttenoire, J., Moradpour, D., et al. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-11 · Cited by 159
Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, G., Park, M.-S., Iadanza, M. G., Zheng, H., & Gonen, T. (2014) · Nature Communications · doi:10.1038/ncomms5521 · Cited by 158
Cura, A. J., & Carruthers, A. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110024 · Cited by 171
Ma, Y., Wang, W., Idowu, M. O., Oh, U., Wang, X.-Y., Temkin, S. M., & Fang, X. (2018) · Cancers · doi:10.3390/cancers11010033 · Cited by 145
Novel pathogenic pathways in diabetic neuropathy
Zenker, J., Ziegler, D., & Chrast, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.008 · Cited by 148
Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Zhang, Y., Li, Q., Huang, Z., Li, B., Nice, E. C., Huang, C., Wei, L., & Zou, B. (2022) · Cancers · doi:10.3390/cancers14194568 · Cited by 144
Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer
Hevia, D., González‐Menéndez, P., Quirós-González, I., Miar, A., Rodríguez‐García, A., Tan, D. X., Reiter, R. J., Mayo, J. C., & Sainz, R. M. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12210 · Cited by 144
The glucose transporter type 1 (Glut1) syndromes
Koch, H., & Weber, Y. G. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.06.010 · Cited by 144
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
Maekawa, Y., Ishifune, C., Tsukumo, S., Hozumi, K., Yagita∥, H., & Yasutomo, K. (2014) · Nature Medicine · doi:10.1038/nm.3758 · Cited by 141
Hypoglycemia in the preterm neonate: etiopathogenesis, diagnosis, management and long-term outcomes
Sharma, A., Davis, A. O., & Shekhawat, P. (2017) · Translational Pediatrics · doi:10.21037/tp.2017.10.06 · Cited by 139
Human placental glucose transport in fetoplacental growth and metabolism
Illsley, N. P., & Baumann, M. U. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.010 · Cited by 145
Transcriptional control of energy metabolism by nuclear receptors
Scholtes, C., & Giguère, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00486-7 · Cited by 132
Cho, S. J., Moon, J.-S., Lee, C.-M., Choi, A. M. K., & Stout-Delgado, H. W. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0225oc · Cited by 133
Crystal structure of a glucose/H + symporter and its mechanism of action
Iancu, C. V., Zamoon, J., Woo, S. B., Aleshin, A. E., & Choe, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311485110 · Cited by 132
Reeves, K. D., Sit, R. W. S., & Rabago, D. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.06.001 · Cited by 139
Choi, C. (2016) · Molecules · doi:10.3390/molecules21091136 · Cited by 136
The Tangled Circuitry of Metabolism and Apoptosis
Andersen, J. L., & Kornbluth, S. A. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.026 · Cited by 132
Sayem, A. S. M., Arya, A., Karimian, H., Krishnasamy, N., Hasamnis, A. A., & Hossain, C. F. (2018) · Molecules · doi:10.3390/molecules23020258 · Cited by 133
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia–Reperfusion Injury
Rabbani, N., & Thornalley, P. J. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.011 · Cited by 126
Frolova, A. I., & Moley, K. H. (2011) · Reproduction · doi:10.1530/rep-11-0114 · Cited by 128
Tuck, C. J., Muir, J. G., Barrett, J. S., & Gibson, P. R. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.917956 · Cited by 124
Src: coordinating metabolism in cancer
Pelaz, S. G., & Tabernero, A. (2022) · Oncogene · doi:10.1038/s41388-022-02487-4 · Cited by 128
GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma
Sun, H.-W., Yu, X.-J., Wu, W., Chen, J., Shi, M., Zheng, L., & Xu, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168907 · Cited by 121
Katzenberger, R. J., Chtarbanova, S., Rimkus, S. A., Fischer, J. A., Kaur, G., Seppala, J. M., Swanson, L. C., Zajac, J. E., Ganetzky, B., & Wassarman, D. A. (2015) · eLife · doi:10.7554/elife.04790 · Cited by 125
SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy
Mayer, A. L., Higgins, C. B., Heitmeier, M. R., Kraft, T. E., Qian, X., Crowley, J. R., Hyrc, K. L., Beatty, W. L., Yarasheski, K. E., Hruz, P. W., et al. (2016) · Scientific Reports · doi:10.1038/srep38586 · Cited by 121
Role of Metabolism in the Immunobiology of Regulatory T Cells
Galgani, M., Rosa, V. D., Cava, A. L., & Matarese, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600242 · Cited by 115
MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells
Chen, B., Liu, Y., Jin, X., Lu, W., Liu, J., Xia, Z., Yuan, Q., Zhao, X., Xu, N., & Liang, S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-443 · Cited by 117
Pompura, S. L., Wagner, A., Kitz, A., Laperche, J. M., Yosef, N., Dominguez‐Villar, M., & Hafler, D. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138519 · Cited by 121
Cognitive dysfunction in diabetes: abnormal glucose metabolic regulation in the brain
Zhang, S., Zhang, Y., Wen, Z., Yang, Y., Bu, T., Bu, X., & Ni, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192602 · Cited by 130
Functional architecture of MFS d -glucose transporters
Madej, M. G., Sun, L., Yan, N., & Kaback, H. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400336111 · Cited by 115
Nutrient transporters: the Achilles’ heel of anabolism
McCracken, A. N., & Edinger, A. L. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.01.002 · Cited by 116
Kuo, C.-C., Ling, H., Chiang, M., Chung, C.-H., Lee, W., Chu, C., Wu, Y.-C., Chen, C., Lai, Y., Tsai, I., et al. (2019) · Theranostics · doi:10.7150/thno.32915 · Cited by 112
Huang, Y., Li, L., Liu, D., Jovin, I. S., Russell, R. R., Johnson, R. S., Lorenzo, A. D., & Giordano, F. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209281109 · Cited by 114
Tolerable upper intake level for dietary sugars
EFSA Panel on Nutrition, N. F. A. F. A. (., Turck, D., Bohn, T., Castenmiller, J. J. M., Henauw, S. D., Hirsch‐Ernst, K. I., Knutsen, H. K., Maciuk, A., Mangelsdorf, I., McArdle, H. J., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7074 · Cited by 133
Metadata
- Authors
- Thorens, B., & Mueckler, M.
- Affiliations
- University of Lausanne (CH)
- Washington University in St. Louis (US)
- Corresponding author
- Mueckler, Mike
- ORCID
- Thorens, Bernard
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2010-02
- Volume
- 298
- Issue
- 2
- Pages
- E141-E145
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC2822486
- OpenAlex
- W2112331117
- Cited by
- 1,013
- References
- 51
- Citations by year
- 2026: 36 · 2025: 57 · 2024: 87 · 2023: 74 · 2022: 70 · 2021: 76 · 2020: 80 · 2019: 62 · 2018: 94 · 2017: 59 · 2016: 58 · 2015: 63 · 2014: 63 · 2013: 43 · 2012: 61
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- U.S. Public Health Service (R0143695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- glucose transporters, GLUT family, glucose homeostasis, fructose transport, urate transport, membrane transporters
- MeSH terms
- Glucose, Humans, Membrane Transport Proteins, Glucose Transport Proteins, Facilitative
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
