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Cited by 142Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes

Minuk, H. L., Vranic, M., Marliss, E. B., Hanna, A. K., Albisser, A. M., Zinman, B.·1981·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1981.240.5.e458
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Abstract

The metabolic response to exercise in obese postabsorptive noninsulin-dependent diabetics was compared to that of obese nondiabetics. Exercise consisted of 45 min on a cycle ergometer at 60% maximum oxygen consumption. Six diabetic subjects were studied during oral hypoglycemic therapy and four on diet alone. The sulfonylurea therapy had no effect on the response. Glycemia was elevated at rest in both diabetic subgroups (192 +/- 24 mg/dl for diet alone, 226 +/- 36 mg/dl for sulfonylurea treatment) and a similar fall (35 and 37 mg/dl, respectively) occurred with exercise. In control subjects, glycemia was 86 +/- 4 mg/dl and did not change with exercise. In the diabetics at rest, glucose production was elevated (220 +/- 25 mg/min), whereas the metabolic clearance of glucose was suppressed. During exercise the increase in glucose utilization was similar to that in controls, but glucose production failed to increase significantly, thus accounting for the decline in plasma glucose. At rest, plasma immunoreactive insulin (IRI) was elevated to 0.90 ng/ml in the controls and decreased to 0.65 ng/ml with exercise. In the diabetics IRI was similarly elevated (0.89 ng/ml) but failed to decrease normally with exercise. Lactate, pyruvate, alanine, and free fatty acids increased similarly in diabetics and controls, whereas the increase in 3-hydroxybutyrate during recovery was less in diabetics. The sustained insulinemia, the basal overproduction of glucose, and hyperglycemia itself may all…

Overview

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Crossref · 10.1152/ajpendo.1981.240.5.e458

Cites

34 of 34 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 9

  1. ALTSZULER N., E., 1979, Diabetes, 28, 358
  2. BJ~RNTORP P., K., 1976, MetaboZism, 25, 631
  3. BJ~RNTORP P., G., 1977, MetaboZism, 26, 319
  4. ISSEKUTZ B., 1980, Metab. 1), E13
  5. KOIVISTO V. A., 1978, N. EngZ. J. Med., 298, 77
  6. MARLISS E. B., 1978, J. CZin. Invest., 62, 463
  7. MINUK H. L., 1980, Metab. 1), E322
  8. RADZIUK J., K., 1978, Metab. Gastrointest. PhysioZ. 3), E84
  9. STEELE R. G., 1960, McGraw-Hill, 107

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Metadata

Authors
Minuk, H. L., Vranic, M., Marliss, E. B., Hanna, A. K., Albisser, A. M., & Zinman, B.
ORCID
Zinman, B.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1981-05-01
Volume
240
Issue
5
Pages
E458-E464
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1981.240.5.e458
OpenAlex
W2308921141
Cited by
142
References
34
Citations by year
2025: 4 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 8
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
type 2 diabetes, obesity, exercise metabolism, glucose regulation, glucose production, glucose utilization, insulin levels, sulfonylurea therapy, hyperglycemia, ketone bodies, beta-hydroxybutyrate, lactate, free fatty acids, postabsorptive state
MeSH terms
Adult, Blood Glucose, Diabetes Mellitus, Physical Exertion, Female, Glucagon, Glucose, Heart Rate, Humans, Insulin, Male, Middle Aged, Obesity, Respiration

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