The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes
Abstract
The metabolic response to exercise in obese postabsorptive noninsulin-dependent diabetics was compared to that of obese nondiabetics. Exercise consisted of 45 min on a cycle ergometer at 60% maximum oxygen consumption. Six diabetic subjects were studied during oral hypoglycemic therapy and four on diet alone. The sulfonylurea therapy had no effect on the response. Glycemia was elevated at rest in both diabetic subgroups (192 +/- 24 mg/dl for diet alone, 226 +/- 36 mg/dl for sulfonylurea treatment) and a similar fall (35 and 37 mg/dl, respectively) occurred with exercise. In control subjects, glycemia was 86 +/- 4 mg/dl and did not change with exercise. In the diabetics at rest, glucose production was elevated (220 +/- 25 mg/min), whereas the metabolic clearance of glucose was suppressed. During exercise the increase in glucose utilization was similar to that in controls, but glucose production failed to increase significantly, thus accounting for the decline in plasma glucose. At rest, plasma immunoreactive insulin (IRI) was elevated to 0.90 ng/ml in the controls and decreased to 0.65 ng/ml with exercise. In the diabetics IRI was similarly elevated (0.89 ng/ml) but failed to decrease normally with exercise. Lactate, pyruvate, alanine, and free fatty acids increased similarly in diabetics and controls, whereas the increase in 3-hydroxybutyrate during recovery was less in diabetics. The sustained insulinemia, the basal overproduction of glucose, and hyperglycemia itself may all…
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In the citing paper
“In the postabsorptive state exercise of moderate intensity has been shown to decrease plasma glucose concentrations and is followed by an increase in insulin sensitivity [1-5].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [1]
In the citing paper
“The finding of no change in glucose production in response to exercise in the postprandial state is in line with the facts that often an increase in hepatic glucose production is not seen with exercise when insulin levels are elevated [1, 7, 22, 23] and that exercise does not change glucose absorption from the gut [24].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [1]
In the citing paper
“In individuals with type 2 diabetes performing moderate exercise, BG utilization by muscles usually rises more than hepatic glucose production, and BG levels tend to decline ( 191 ).”
From Exercise and Type 2 Diabetes (2010) · cites this paper as [191]
Citations
Cites
Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.
Olefsky, J. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108384 · Cited by 343
The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes
Olefsky, J. M. (1976) · Diabetes · doi:10.2337/diab.25.12.1154 · Cited by 289
The effect of physical training on insulin production in obesity
Björntorp, P. A., de Jounge, K., Sjöström, L., & Sullivan, L. (1970) · Metabolism · doi:10.1016/0026-0495(70)90020-x · Cited by 281
Experimental validation of measurements of glucose turnover in nonsteady state.
Radziuk, J., Norwich, K. H., & Vranic, M. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.1.e84 · Cited by 277
Effects of Leg Exercise on Insulin Absorption in Diabetic Patients
Koivisto, V. A., & Felig, P. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801122980205 · Cited by 254
Cherrington, A. D., Chiasson, J. L., Liljenquist, J. E., Jennings, A. S., Keller, U., & Lacy, W. W. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108596 · Cited by 249
Metabolic and hormonal effects of muscular exercise in juvenile type diabetics
Berger, M., Berchtold, P., C�ppers, H. J., Drost, H., Kley, H. K., M�ller, W. A., Wiegelmann, W., Zimmermann-Telschow, H., Gries, F. A., Kr�skemper, H. L., et al. (1977) · Diabetologia · doi:10.1007/bf01223279 · Cited by 247
Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method
Cowan, J. S., & Hetenyi, G., Jr. (1971) · Metabolism · doi:10.1016/0026-0495(71)90098-9 · Cited by 239
Wahren, J., Hagenfeldt, L., & Felig, P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108050 · Cited by 213
Exercise and Diabetes Mellitus
Vranić, M., & Berger, M. (1979) · Diabetes · doi:10.2337/diab.28.2.147 · Cited by 212
Research works printed but not linked: 9
- ALTSZULER N., E., 1979, Diabetes, 28, 358
- BJ~RNTORP P., K., 1976, MetaboZism, 25, 631
- BJ~RNTORP P., G., 1977, MetaboZism, 26, 319
- ISSEKUTZ B., 1980, Metab. 1), E13
- KOIVISTO V. A., 1978, N. EngZ. J. Med., 298, 77
- MARLISS E. B., 1978, J. CZin. Invest., 62, 463
- MINUK H. L., 1980, Metab. 1), E322
- RADZIUK J., K., 1978, Metab. Gastrointest. PhysioZ. 3), E84
- STEELE R. G., 1960, McGraw-Hill, 107
Cited by
Sorted by citations
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan-Taber, L., Albright, A. L., & Braun, B. (2010) · Diabetes Care · doi:10.2337/dc10-9990 · Cited by 1,955
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
Physical Activity/Exercise and Type 2 Diabetes
Sigal, R. J., Kenny, G. P., Wasserman, D. H., & Castaneda-Sceppa, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2518 · Cited by 763
(2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eeb61c · Cited by 567
Invited Review: Effects of acute exercise and exercise training on insulin resistance
Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535
Metadata
- Authors
- Minuk, H. L., Vranic, M., Marliss, E. B., Hanna, A. K., Albisser, A. M., & Zinman, B.
- ORCID
- Zinman, B.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1981-05-01
- Volume
- 240
- Issue
- 5
- Pages
- E458-E464
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2308921141
- Cited by
- 142
- References
- 34
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- type 2 diabetes, obesity, exercise metabolism, glucose regulation, glucose production, glucose utilization, insulin levels, sulfonylurea therapy, hyperglycemia, ketone bodies, beta-hydroxybutyrate, lactate, free fatty acids, postabsorptive state
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Physical Exertion, Female, Glucagon, Glucose, Heart Rate, Humans, Insulin, Male, Middle Aged, Obesity, Respiration
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