The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Enhanced muscle glucose metabolism after exercise: modulation by local factors
Abstract
Studies in the rat suggest that after voluntary exercise there are two phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase in the presence of insulin is found. To determine whether these alterations and in particular those mediated by insulin are due to local or systemic factors, one hindlimb of an anesthetized rat was electrically stimulated, and both hindlimbs were perfused immediately thereafter. Glucose and glycogen metabolism in the stimulated leg closely mimicked that observed previously after voluntary exercise on a treadmill. With no insulin added to the perfusate, glucose incorporation into glycogen was markedly enhanced in muscles that were glycogen depleted as were the uptake of 2-deoxyglucose and 3-O-methylglucose. Likewise, the stimulation of these processes by insulin was enhanced and continued to be so 2 h later when the muscles of the stimulated leg had substantially repleted their glycogen stores. The results suggest that the increases in insulin-mediated glucose utilization and glycogen synthesis in muscle after exercise are modulated by local contraction-induced factors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“During exercise, muscle glucose uptake increases but the process induced by muscle contractions is not dependent on insulin 53.”
From Effect of exercise training on insulin-stimulated glucose disposal: A systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [53]
In the citing paper
“However, exerciseinduced enhancement of glucose clearance in the post exercise period is closely related to the depletion of muscle glycogen during exercise [28, 29, 31], and it wanes as glycogen stores are replenished by food intake [31].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [29]
In the citing paper
“The mechanism for this may include enhancement of both non-insulin and insulin-mediated glucose transport and disposal [28, 29].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [29]
Citations
Cites
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198
HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS
Ariano, M. A., Edgerton, V. R., & Armstrong, R. B. (1973) · Journal of Histochemistry & Cytochemistry · doi:10.1177/21.1.51 · Cited by 1,118
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction
Kahn, C. R. (1978) · Metabolism · doi:10.1016/s0026-0495(78)80007-9 · Cited by 793
Muscle Glucose Metabolism following Exercise in the Rat
Richter, E. A., Garetto, L. P., Goodman, M. N., & Ruderman, N. B. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110517 · Cited by 510
Self-citationLowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.50011-5 · Cited by 457
Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism
Ruderman, N. B., Houghton, C. R. S., & Hems, R. (1971) · Biochemical Journal · doi:10.1042/bj1240639 · Cited by 446
Self-citationStudies of Tissue Permeability
Holloszy, J. O., & NARAHARA, H. T. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97170-x · Cited by 224
Muscle Metabolites during Submaximal and Maximal Exercise in Man
Karlsson, J., Diamant, B., & Saltin, B. (1970) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517009046250 · Cited by 172
Maizels, E. T., Ruderman, N. B., Goodman, M. N., & Lau, D. (1977) · Biochemical Journal · doi:10.1042/bj1620557 · Cited by 169
Self-citation
Research works printed but not linked: 3
- GARETTO L. P., 1982, Physiologist, 25, 252
- SHIKAMA H., D., Am. J. Physiol., 242
- TAN M., 1983, Excerpta Med. Int. Congr. Ser., 577, 182
Cited by
Sorted by citations
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782
AMPK in skeletal muscle function and metabolism
Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C. K., Shum, M., Marette, A., Mounier, R., Treebak, J. T., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700442r · Cited by 517
Exercise-induced increase in muscle insulin sensitivity
Holloszy, J. O. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00123.2005 · Cited by 494
Glucose transporter protein content and glucose transport capacity in rat skeletal muscles
Henriksen, E. J., Bourey, R. E., Rodnick, K. J., Koranyi, L. I., Permutt, M. A., & Holloszy, J. O. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.4.e593 · Cited by 432
Exercise regulation of glucose transport in skeletal muscle.
Hayashi, T., Wojtaszewski, J., & Goodyear, L. (1997) · American Journal of Physiology · doi:10.1152/ajpendo.1997.273.6.e1039 · Cited by 394
Metadata
- Authors
- Richter, E. A., Garetto, L. P., Goodman, M. N., & Ruderman, N. B.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1984-06-01
- Volume
- 246
- Issue
- 6
- Pages
- E476-E482
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2181090774
- Cited by
- 194
- References
- 17
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 3 · 2012: 5
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- muscle glucose metabolism, glycogen repletion, skeletal muscle, insulin, physical activity, neuromuscular electrical stimulation, glycogen synthesis, glucose uptake, local factors, 2-deoxyglucose, 3-O-methylglucose
- MeSH terms
- Adenosine Triphosphate, Animals, Deoxyglucose, Electric Stimulation, Glucose, Glycogen, Glycogen Synthase, Hindlimb, Insulin, Male, Motor Activity, Muscles, Phosphocreatine, Rats, Inbred Strains, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
