Cited by 337Circadian rhythm and melatoninSleep and Wakefulness ResearchStress Responses and Cortisol

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Neuroendocrine rhythms and sleep in aging men

van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Baleriaux, M., Decoster, C., Neve, P., Van Cauter, E.·1991·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1991.260.4.e651

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Abstract

To delineate the physiological effects of aging on basal levels and temporal patterns of neuroendocrine secretions, the 24-h profiles of cortisol, thyroid-stimulating hormone (TSH), melatonin, prolactin, and growth hormone (GH) levels were simultaneously obtained at frequent intervals in eight healthy, active elderly men, age 67-84 yr and in eight young male adults, age 20-27 yr. The study was preceded by an extended period of habituation to laboratory conditions, and sleep was polygraphically recorded. Mean cortisol levels in the elderly were normal, but the amplitude of the circadian rhythm was reduced. Circulating levels of daytime and nighttime levels of both TSH and GH were greatly diminished in old age. In contrast, prolactin and melatonin concentrations were decreased during the nighttime only. The circadian rises of cortisol, TSH, and melatonin occurred 1-1.5 h earlier in elderly subjects, and the distribution of rapid-eye-movement stages during sleep was similarly advanced, suggesting that circadian timekeeping is modified during normal senescence. Despite perturbations of sleep, sleep-related release of GH and prolactin occurred in all elderly men. Age-related decreases in hormonal levels were associated with a decrease in the amplitude, but not the frequency, of secretory pulses. These findings demonstrate that the normal process of aging involves alterations in the central mechanisms controlling the temporal organization of endocrine release in addition to a reduction of secretory outputs.

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Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Radioimmunoassay of Serum Concentrations of Melatonin in Sheep Exposed to Different Lighting Regimens
Rollag, M. D., & Niswender, G. D. (1976) · Endocrinology · doi:10.1210/endo-98-2-482 · Cited by 641
Age-related change in the twenty-four-hour spontaneous secretion of growth hormone
FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-5-665 · Cited by 640
Human Melatonin Production Decreases With Age
Sack, R. L., Lewy, A. J., Erb, D. L., Vollmer, W. M., & Singer, C. M. (1986) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1986.tb00760.x · Cited by 415
Alterations in Nocturnal Serum Melatonin Levels In Humans With Growth and Aging*
Waldhauser, F., Weiszenbacher, G., Tatzer, E., Gisinger, B., Waldhauser, M., SCHEMPER, M., & Frisch, H. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-3-648 · Cited by 407
Response to Thyrotropin Releasing Hormone (TRH) in Normal Man
Snyder, P. J., & Utiger, R. D. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-2-380 · Cited by 386
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Weitzman, E. D., Moline, M. L., Czeisler, C. A., & Zimmerman, J. C. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90018-5 · Cited by 367
AGE-RELATED CHANGES IN PLASMA GROWTH HORMONE RESPONSE TO GROWTH HORMONE-RELEASING FACTOR IN MAN
Shibasaki, T., SHIZUME, K., Nakahara, M., Masuda, A., Jibiki, K., Demura, H., Wakabayashi, I., & LING, N. C. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-212 · Cited by 231
Age-Related Changes in the Circadian Rhythm of Plasma Cortisol in Man*
Sherman, B. M., WYSHAM, W., & PFOHL, B. M. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-3-439 · Cited by 230
“White Paper” on Sleep and Aging
Dement, W. C., Miles, L. E. M., & Carskadon, M. A. (1982) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1982.tb03700.x · Cited by 222

Show all 37 references

Research works printed but not linked: 16

BLACKMAN M. R, 1990, PA: Lippincott, 1461
EVERITT A. V, 1980, GerontoZogy, 26, 108
MCGINTY D., 1988, R. Sowersand and J. V. Felicetta. New York: Raven, 75
PRINZ P. N., 1983, NY: Spectrum, 463
TAKAHASHI Y., D., 1968, J. CZin. Inuest., 47, 2079
THOMAS D. R., 1989, Psychiatry, 25, 363
1989, Metab., 69, 177
BOGDAN, 1986, Elsevier, 255
URBAN R. J., 1988, R. Sowers and J. V. Felicetta. New York: Raven, 41
VAN CAUTER E, 1979, Metab. Gastrointest. Physiol. 6), E255
VAN CAUTER E, 1988, Metab. 17), E786
VAN CAUTER E, 1989, Edwards and D. Lincoln. Edinburgh: Churchill Livingstone, 109
VAN CAUTER E., M., 1981, Metab. 4), E355
WEITZMAN E. D., 1980, Trans. Am. Neurol. Assoc., 371
WEVER R, 1979, Results of Experiments Under Temporal Isolation. New York: Springer-Verlag, 276
ZAKRIA F., N., 1988, Chronobiolokz, 15, 219

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Authors: van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Baleriaux, M., Decoster, C., Neve, P., & Van Cauter, E.
Affiliations: School of Medicine, Universite Libre de Bruxelles, Belgium.
Université Libre de Bruxelles (BE)
ORCID: Neve, P.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1991-04-01
Volume: 260
Issue: 4
Pages: E651-E661
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1991.260.4.e651
OpenAlex: W1776470977
Cited by: 336
References: 37
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 4 · 2013: 9 · 2012: 11
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: aging, circadian rhythm, sleep, cortisol, thyroid-stimulating hormone, melatonin, prolactin, growth hormone, REM sleep, older men, circadian timing
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Circadian Rhythm, Humans, Hydrocortisone, Male, Melatonin, Prolactin, Sleep, Sleep, REM, Growth Hormone, Thyrotropin, Wakefulness

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Neuroendocrine rhythms and sleep in aging men

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