Cited by 337Circadian rhythm and melatoninSleep and Wakefulness ResearchStress Responses and Cortisol

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Neuroendocrine rhythms and sleep in aging men

van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Baleriaux, M., Decoster, C., Neve, P., Van Cauter, E.·1991·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1991.260.4.e651

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Abstract

To delineate the physiological effects of aging on basal levels and temporal patterns of neuroendocrine secretions, the 24-h profiles of cortisol, thyroid-stimulating hormone (TSH), melatonin, prolactin, and growth hormone (GH) levels were simultaneously obtained at frequent intervals in eight healthy, active elderly men, age 67-84 yr and in eight young male adults, age 20-27 yr. The study was preceded by an extended period of habituation to laboratory conditions, and sleep was polygraphically recorded. Mean cortisol levels in the elderly were normal, but the amplitude of the circadian rhythm was reduced. Circulating levels of daytime and nighttime levels of both TSH and GH were greatly diminished in old age. In contrast, prolactin and melatonin concentrations were decreased during the nighttime only. The circadian rises of cortisol, TSH, and melatonin occurred 1-1.5 h earlier in elderly subjects, and the distribution of rapid-eye-movement stages during sleep was similarly advanced, suggesting that circadian timekeeping is modified during normal senescence. Despite perturbations of sleep, sleep-related release of GH and prolactin occurred in all elderly men. Age-related decreases in hormonal levels were associated with a decrease in the amplitude, but not the frequency, of secretory pulses. These findings demonstrate that the normal process of aging involves alterations in the central mechanisms controlling the temporal organization of endocrine release in addition to a reduction of secretory outputs.

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Authors: van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Baleriaux, M., Decoster, C., Neve, P., & Van Cauter, E.
Affiliations: School of Medicine, Universite Libre de Bruxelles, Belgium.
Université Libre de Bruxelles (BE)
ORCID: Neve, P.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1991-04-01
Volume: 260
Issue: 4
Pages: E651-E661
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1991.260.4.e651
OpenAlex: W1776470977
Cited by: 336
References: 37
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 4 · 2013: 9 · 2012: 11
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: aging, circadian rhythm, sleep, cortisol, thyroid-stimulating hormone, melatonin, prolactin, growth hormone, REM sleep, older men, circadian timing
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Circadian Rhythm, Humans, Hydrocortisone, Male, Melatonin, Prolactin, Sleep, Sleep, REM, Growth Hormone, Thyrotropin, Wakefulness

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Neuroendocrine rhythms and sleep in aging men

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