The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Effect of insulin on uric acid excretion in humans
Abstract
Although hyperuricemia is a frequent finding in insulin-resistant states, insulin's effect on renal uric acid (UA) handling is not known. In 20 healthy volunteers, diastolic blood pressure, body weight, and fasting plasma insulin were positively (and age was negatively) related to fasting plasma UA concentrations, together accounting for 53% of their variability. During an insulin clamp, urine flow was lower than during fasting conditions (1.01 +/- 0.12 vs. 1.56 +/- 0.32 ml/min, P = 0.04), whereas creatinine clearance was unchanged (129 +/- 7 and 131 +/- 9 ml/min, P = not significant). Hyperinsulinemia did not alter serum UA concentrations (303 +/- 13 vs. 304 +/- 12 microM) but caused a significant decrease in urinary UA excretion [whether expressed as absolute excretion rate (1.66 +/- 0.21 vs. 2.12 +/- 0.23 mumol/min, P = 0.03), clearance rate (5.6 +/- 0.8 vs. 7.3 +/- 0.8 ml/min, P = 0.03), or fractional excretion (4.48 +/- 0.80 ml/min vs. 6.06 +/- 0.64%, P < 0.03)]. Hyperinsulinemia was also associated with a 30% (P < 0.001) fall in urine Na excretion. Fractional UA excretion was related to Na fractional excretion under basal conditions (r = 0.59, P < 0.01) and during the insulin period (r = 0.53, P < 0.02). Furthermore, the insulin-induced changes in fractional UA and Na excretion correlated with one another (r = 0.66, P < 0.001). Physiological hyperinsulinemia acutely reduces urinary UA and Na excretion in a coupled fashion.
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Cites
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344
Self-citationFacchini, F. (1991) · JAMA · doi:10.1001/jama.1991.03470210076036 · Cited by 885
Pollare, T., Lithell, H., & Berne, C. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909283211305 · Cited by 856
Effects of arterial versus venous sampling on analysis of glucose kinetics in man
McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704
Hyperuricemia in Primary and Renal Hypertension
Cannon, P. J., Stason, W. B., Demartini, F. E., Sommers, S. C., & Laragh, J. H. (1966) · New England Journal of Medicine · doi:10.1056/nejm196609012750902 · Cited by 505
SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASE
GERTLER, M. M., GARN, S. M., & LEVINE, S. A. (1951) · Annals of Internal Medicine · doi:10.7326/0003-4819-34-6-1421 · Cited by 351
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Elevated serum uric acid ? a facet of hyperinsulinaemia
Modan, M., Halkin, H., Karasik, A., & Lusky, A. (1987) · Diabetologia · doi:10.1007/bf00296994 · Cited by 263
Effect of insulin on the distribution and disposition of glucose in man.
Ferrannini, E., Smith, J. D., Cobelli, C., Toffolo, G., Pilo, A., & DeFronzo, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111969 · Cited by 254
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Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Johnson, R. J., Kang, D.-H., Feig, D., Kivlighn, S., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodriguez-Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000069700.62727.c5 · Cited by 1,361
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Study, L. C., Köttgen, A., CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2500 · Cited by 836
Uric acid and chronic kidney disease: which is chasing which?
Johnson, R. J., Nakagawa, T., Jalal, D., Sanchez-Lozada, L. G., Kang, D.-H., & Ritz, E. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft029 · Cited by 654
Verdecchia, P., Schillaci, G., Reboldi, G., Santeusanio, F., Porcellati, C., & Brunetti, P. (2000) · Hypertension · doi:10.1161/01.hyp.36.6.1072 · Cited by 558
Association Between Serum Uric Acid and Development of Type 2 Diabetes
Kodama, S., Saito, K., Yachi, Y., Asumi, M., Sugawara, A., Totsuka, K., Saito, A., & Sone, H. (2009) · Diabetes Care · doi:10.2337/dc09-0288 · Cited by 549
Metadata
- Authors
- Quinones Galvan, A., Natali, A., Baldi, S., Frascerra, S., Sanna, G., Ciociaro, D., & Ferrannini, E.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1995-01-01
- Volume
- 268
- Issue
- 1
- Pages
- E1-E5
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2289400802
- Cited by
- 451
- References
- 20
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quinones Galvan, A., Natali, A., Baldi, S., Frascerra, S., Sanna, G., Ciociaro, D., & Ferrannini, E. (1995). Effect of insulin on uric acid excretion in humans. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1995.268.1.e1
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