The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Alterations of lipolysis and lipoprotein lipase in chronically nicotine-treated rats
Abstract
These studies examined the cellular mechanisms for lower adiposity seen with nicotine ingestion. Rats were infused with nicotine or saline for 1 wk and adipocytes isolated from epididymal fat pads. Nicotine-infused rats gained 37% less weight and had 21% smaller fat pads. Basal lipolysis was 78% higher, whereas the maximal lipolytic response to isoproterenol was blunted in adipocytes from nicotine-infused rats. The antilipolytic actions of adenosine and the levels of serum catecholamines were unaffected by nicotine. The nicotine-induced alteration in lipolysis was not associated with any changes in hormone-sensitive lipase. Nicotine caused a 30% decrease in lipoprotein lipase (LPL) activity, without any changes in LPL mass or mRNA levels, in epididymal fat in the fed state. In contrast, LPL activity, mass, and mRNA levels in heart were increased by nicotine whether animals were fed or fasted. These studies provide evidence for multiple mechanistic events underlying nicotine-induced alterations in weight and suggest that nicotine diverts fat storage away from adipose tissue and toward utilization by muscle.
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“Nicotine infusion stimulates lipolysis to increase triglyceride levels in both human and animal studies (Sztalryd et al., 1996; Andersson and Arner, 2001)”
From Cigarette Smoking and Brain Regulation of Energy Homeostasis (2012) · cites this paper as Sztalryd et al., 1996
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Cited by
Nicotine and cannabinoids: parallels, contrasts and interactions
VIVEROS, M., MARCO, E., & FILE, S. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.08.002 · Cited by 106
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Metadata
- Authors
- Sztalryd, C., Hamilton, J., Horwitz, B. A., Johnson, P., & Kraemer, F. B.
- Affiliations
- Department of Medicine, Stanford University School of Medicine,California 94305, USA.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1996-02-01
- Volume
- 270
- Issue
- 2
- Pages
- E215-E223
- ISSN
- 0193-1849
- 1522-1555
- Cited by
- 9
- References
- 2
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
