The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein
Abstract
Mechanisms of protein gain during protein feeding have been investigated using a combination of oral and intravenous labeled leucine in healthy young men. The oral labeled leucine was administered as a free oral tracer ([13C]- or [2H3]leucine) added to unlabeled whey protein or as whey protein intrinsically labeled with L-[1-13C]leucine. When the oral tracer was free leucine, it appeared in the plasma more rapidly than the unlabeled leucine derived from the whey protein, and this resulted in an artifactual 88% decrease of protein breakdown. When the oral tracer was protein bound, protein breakdown did not change significantly after the meal. In contrast, nonoxidative leucine disposal (i.e., protein synthesis) was stimulated by 63% by the meal. In conclusion, 1) an intrinsically labeled protein is more appropriate than an oral free tracer to study postprandial leucine kinetics under non-steady-state conditions and 2) protein gain after a single whey protein meal results solely from an increased protein synthesis with no modification of protein breakdown.
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“For example, different types of proteins (e.g., casein, whey, and soy) are digested at different rates, which may affect whole body catabolism and anabolism and acute stimulation of muscle protein synthesis (MPS) [91–96].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [94]
Citations
Cites
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Self-citationFailure of Infused β-Hydroxybutyrate to Decrease Proteolysis in Man
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Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738
Self-citationSlow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453
Self-citationISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945
Pennings, B., Boirie, Y., Senden, J. M., Gijsen, A. P., Kuipers, H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.008102 · Cited by 656
Self-citationThe digestion rate of protein is an independent regulating factor of postprandial protein retention
Dangin, M., Boirie, Y., Garcia-Rodenas, C., Gachon, P., Fauquant, J., Callier, P., Ballèvre, O., & Beaufrère, B. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e340 · Cited by 572
Self-citation
Metadata
- Authors
- Boirie, Y., Gachon, P., Corny, S., Fauquant, J., Maubois, J. L., & Beaufrere, B.
- Affiliations
- Laboratoire de Nutrition Humaine, Universite Clermont Auvergne,Clermont-Ferrand, France.
- Université Clermont Auvergne (FR)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1996-12-01
- Volume
- 271
- Issue
- 6
- Pages
- E1083-E1091
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1945646895
- Cited by
- 174
- References
- 12
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- leucine metabolism, protein degradation, whey protein, protein gain, leucine kinetics, non-steady state
- MeSH terms
- Administration, Oral, Adult, Carbon Radioisotopes, Humans, Injections, Intravenous, Leucine, Male, Milk Proteins, Tritium, Postprandial Period
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