Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group
Open accessAbstract
The aging process is associated with gradual and progressive loss of muscle mass along with lowered strength and physical endurance. This condition, sarcopenia, has been widely observed with aging in sedentary adults. Regular aerobic and resistance exercise programs have been shown to counteract most aspects of sarcopenia. In addition, good nutrition, especially adequate protein and energy intake, can help limit and treat age-related declines in muscle mass, strength, and functional abilities. Protein nutrition in combination with exercise is considered optimal for maintaining muscle function. With the goal of providing recommendations for health care professionals to help older adults sustain muscle strength and function into older age, the European Society for Clinical Nutrition and Metabolism (ESPEN) hosted a Workshop on Protein Requirements in the Elderly, held in Dubrovnik on November 24 and 25, 2013. Based on the evidence presented and discussed, the following recommendations are made (a) for healthy older people, the diet should provide at least 1.0-1.2 g protein/kg body weight/day, (b) for older people who are malnourished or at risk of malnutrition because they have acute or chronic illness, the diet should provide 1.2-1.5 g protein/kg body weight/day, with even higher intake for individuals with severe illness or injury, and (c) daily physical activity or exercise (resistance training, aerobic exercise) should be undertaken by all older people, for as long as possible.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Distributing protein intake throughout the day or pulse feeding at main meals could be beneficial for stimulating muscle protein synthesis in patients with sarcopenic obesity.
“Distributing protein intake throughout the day259 or pulse feeding at main meals260 could be beneficial for the stimulation of muscle protein synthesis in patients with sarcopenic obesity.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [259]
The “Protein intake pattern” section says pulse feeding may improve feeding-induced protein synthesis in older adults. The “Sarcopenic obesity and protein intake” section recommends increased protein intake for sarcopenic obesity, but does not specifically recommend pulse feeding or establish its benefit for protein synthesis in those patients. Page numbers were not available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn sarcopenic obesity, protein intake of ≥1.2 g/kg body weight per day, up to 1.5 g/kg/day during caloric restriction, distributed evenly across meals, optimizes anabolic signaling.
“Core interventions include a protein intake of ≥ 1.2 g/kg body Weight per day, up to 1.5 g/kg/day during caloric restriction, distributed evenly across meals to optimize anabolic signaling [118].”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [118]
The “Sarcopenic obesity and protein intake” section recommends moderate calorie restriction with increased protein intake, while “Amount of protein” reports a 1.2–1.4 g/kg/day target for healthy older adults—not a 1.2–1.5 g/kg/day prescription specifically during caloric restriction. “Protein intake pattern” says the optimal distribution across meals remains unclear and notes evidence favoring a single large protein meal, so the claim that even distribution optimizes anabolic signaling is not supported. (LLM, conf=0.88)
Experimental — accuracy not yet measuredImproving nutrition intake with high protein content and being physically active will not completely maintain muscle mass but will slow down loss of muscle and function.
“Improving nutrition intake with high protein content and being physically active will, therefore, not completely maintain muscle mass, but will slow down loss of muscle and function.153”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [153]
The “New insights in aging and declining muscle function” section says adequate protein helps limit age-related declines and that nutrition combined with exercise is optimal for maintaining muscle function. But the claim that these measures will not completely maintain muscle mass is not supported: the “Physical activity and exercise can maintain or enhance muscle mass” section reports that resistance exercise can reverse muscle loss in older adults. The cited passages have no page numbers in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredRecommendations for elevated protein intake (1.2-1.5 g/kg/day in adults with chronic disease, with higher targets up to ~1.6 g/kg/day during active weight loss), combined with resistance training, are supported by primary trial data and aligned international consensus statements, even though no trial has tested these specific targets in GLP-1 RA users.
“Recommendations for elevated protein intake (1.2–1.5 g/kg/day in adults with chronic disease, with higher targets up to ~1.6 g/kg/day during active weight loss), combined with resistance training, are supported by primary trial data and aligned international consensus statements addressing protein requirements in older adults, in chronic disease, and during intentional weight loss [68,69,70,78],”
From Adherence and Persistence with GLP-1-Based Therapies: International Real-World Evidence and the Role of Nutritional and Lifestyle Support—A Narrative Review (2026) · cites this paper as [69]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredDaily amounts of 1.2-1.5 g/kg have been suggested for older persons with acute or chronic illness, and up to 2.0 g/kg body weight and day in case of severe illness, injury or malnutrition.
“Daily amounts of 1.2 -1.5 g/kg have been suggested for older persons with acute or chronic illness (17,18) and up to 2.0 g/kg BW and day in case of severe illness, injury or malnutrition (17).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [18]
The Abstract recommends 1.2–1.5 g protein/kg body weight/day for older people who are malnourished or at risk of malnutrition because of acute or chronic illness. It also recommends higher intake for severe illness or injury, but the passages in our copy do not specify an upper amount of 2.0 g/kg/day. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Levels of 1.2-1.5 g/kg BW/day have been suggested for older persons with acute or chronic illness, and up to 2.0 g/kg BW/day in case of severe illness, injury, or malnutrition.
“Levels of 1.2-1.5 g/kg BW/day have been suggested for older 511 persons with acute or chronic illness [37, 38] and up to 2.0 g/kg BW/day in case of severe 512 illness, injury, or malnutrition [37].”
From ESPEN guideline on hospital nutrition (2021) · cites this paper as [38]
The Abstract recommends 1.2–1.5 g/kg body weight/day for older people who are malnourished or at risk of malnutrition because of acute or chronic illness. It recommends even higher intake for severe illness or injury, but does not specify 2.0 g/kg/day or extend that higher recommendation to malnutrition alone. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe PROT-AGE international position paper recommends a minimum daily intake of 1.0-1.2 g/kg/day for healthy older adults and 1.2-1.5 g/kg/day for those with acute or chronic illness; corresponding ESPEN consensus recommendations align closely.
“The PROT-AGE international position paper, synthesizing nitrogen-balance and clinical-outcome studies, recommends a minimum daily intake of 1.0–1.2 g/kg/day for healthy older adults and 1.2–1.5 g/kg/day for those with acute or chronic illness [68]; corresponding ESPEN consensus recommendations align closely [69].”
From Adherence and Persistence with GLP-1-Based Therapies: International Real-World Evidence and the Role of Nutritional and Lifestyle Support—A Narrative Review (2026) · cites this paper as [69]
Daily amounts of 1.0-1.2 g/kg body weight have been suggested for healthy older persons by several expert groups.
“Daily amounts of 1.0 -1.2 g/kg BW have been suggested for healthy older persons by several expert groups (17)(18)(19).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [18]
After tracheostomy, the majority of patients returned to oral intake, but time to commencement of oral intake was correlated with increased time to decannulation, and increased time to decannulation correlated with increased hospital length of stay.
“After tracheostomy, a cohort study showed that the majority of the patients returned to oral intake, but the time to commencement of oral intake was correlated with increased time to decannulation and increased time to decannulation correlated with increased hospital length of stay (315).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [315]
Split into 3 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 3 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThere is evidence that supplementation with protein/amino acids helps to preserve muscle mass and function in older persons.
“Even though only a few available studies have investigated the effects of nutritional interventions on sarcopenic obesity, there is evidence that supplementation with protein/amino acids, in particular, helps to preserve muscle mass and function in older persons.44”
From Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis (2023) · cites this paper as [44]
Experts and guidelines recommend a combination of moderate calorie restriction, increased protein intake, and exercise for the treatment of sarcopenic obesity.
“Experts and guidelines recommend a combination of moderate calorie restriction, increased protein intake, and exercise for the treatment of sarcopenic obesity.16,44,49,53,55”
From Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis (2023) · cites this paper as [44]
For persons with acute or chronic illness, the ESPEN Expert Group recommends a protein intake of 1.2 to 1.5 g/kg/d.
“For persons with acute or chronic illness, the ESPEN Expert Group recommends a protein intake of 1.2 to 1.5 g/kg/d.44”
From Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis (2023) · cites this paper as [44]
Older people have anabolic resistance, so a higher protein intake is needed to promote muscle protein synthesis.
“While in older people, a higher protein intake should be provided in order to promote muscle protein synthesis due to anabolic resistance.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [149]
Increased dietary protein can prevent weight loss-induced sarcopenia.
“Increased dietary protein can prevent weight loss-induced sarcopenia.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [149]
Older adults may be at high risk of low protein intake and inadequate essential amino acid consumption.
“For example, older adults might be at high risk of a low protein intake and inadequate consumption of essential amino acids89.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [89]
Unintended loss of muscle mass can impair resting metabolic rate, compromise physical function, and increase the risk of sarcopenia, especially in older adults or individuals with lower baseline muscle reserves.
“unintended loss of muscle mass can impair resting metabolic rate, compromise physical function, and increase the risk of sarcopenia, especially in older adults or individuals with lower baseline muscle reserves [27,28].”
From Unintended Consequences of Obesity Pharmacotherapy: A Nutritional Approach to Ensuring Better Patient Outcomes (2025) · cites this paper as [28]
Protein supplementation in combination with resistance-type muscle strengthening exercise is an efficient intervention for lean mass and strength gain in elderly individuals.
“PS in combination with resistance-type MSE has been identified as an efficient intervention for LM and strength gain in elderly individuals [11,13,15,19,59,64].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A New Equation to Estimate Glomerular Filtration Rate
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603 · see citing works
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Self-citationLevey, A. S., Coresh, J., Greene, T., Stevens, L. A., Zhang, Y., Hendriksen, S. M., Kusek, J. W., & Lente, F. V. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-4-200608150-00004 · Cited by 5,726 · see citing works
Ageing populations: the challenges ahead
Christensen, K., Doblhammer, G., Rau, R., & Vaupel, J. W. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61460-4 · Cited by 3,764 · see citing works
Stevens, P. E., Levin, A., & for the Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members* (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-11-201306040-00007 · Cited by 3,607 · see citing works
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · cited 6× · see citing works
“These conditions can result in disability, and eventually to loss of independence, falls and fractures, and death [7].”
BackgroundInfluentialSelf-citationProtein and amino acid requirements in human nutrition.
(2007) · PubMed · Cited by 2,227 · see citing works
Levey, A. S., Coresh, J., Greene, T., Marsh, J., Stevens, L. A., Kusek, J. W., & Lente, F. V. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.077180 · Cited by 1,854 · see citing works
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · see citing works
Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453 · see citing works
Self-citationVisser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Progressive resistance strength training for improving physical function in older adults
Liu, C.-J., & Latham, N. K. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002759.pub2 · Cited by 1,258 · see citing works
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214 · see citing works
Transitions between frailty states among community-living older persons
Gill, T. M., Gahbauer, E. A., Allore, H. G., & Han, L. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.418 · Cited by 1,141 · cited 1× · see citing works
“Notably, frailty can be prevented or reversed by intervention, particularly by greater protein intake and exercise [28,29].”
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096 · see citing works
Sarcopenic obesity: definition, cause and consequences
Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works
Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998 · see citing works
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works
Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910 · see citing works
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846 · see citing works
Nutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664 · cited 1× · see citing works
“2 g/kg body weight/day for adults older than 65 years [5,7,19,20].”
BackgroundSelf-citationMuscle strength and body mass index as long-term predictors of mortality in initially healthy men
Rantanen, T., Harris, T., Leveille, S. G., Visser, M., Foley, D., Masaki, K., & Guralnik, J. M. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.3.m168 · Cited by 647 · see citing works
Nordic Nutrition Recommendations 2012
(2008) · Nord · doi:10.6027/nord2014-002 · Cited by 629 · see citing works
Endurance Exercise as a Countermeasure for Aging
Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582 · see citing works
Self-citationTieland, M., Dirks, M. L., van der Zwaluw, N., Verdijk, L. B., van de Rest, O., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.05.020 · Cited by 556 · cited 2× · see citing works
“Tieland et al. 2012 [91] A randomized, controlled trial with 2 arms in parallel among frail elderly subjects (n ¼ 62, age 78 AE 1 year); subjects did resistance exercise twice weekly for 24 weeks and consumed placebo or protein supplements (15 g) twice daily Prolonged resistance-type exercise…”
MethodKim, H. K., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03776.x · Cited by 551 · see citing works
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521 · see citing works
Areta, J. L., Burke, L. M., Ross, M. L., Camera, D. M., West, D. W. D., Broad, E. M., Jeacocke, N. A., Moore, D. R., Stellingwerff, T., Phillips, S. M., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.244897 · Cited by 495 · see citing works
Wilkinson, D. J., Hossain, T., Hill, D. S., Phillips, B. E., Crossland, H., Williams, J., Loughna, P., Churchward‐Venne, T. A., Breen, L., Phillips, S. M., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.253203 · Cited by 484 · see citing works
Yang, Y., Breen, L., Burd, N. A., Hector, A. J., Churchward-Venne, T. A., Josse, A. R., Tarnopolsky, M. A., & Phillips, S. M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007422 · Cited by 480 · see citing works
Knight, E. L., Stampfer, M. J., Hankinson, S. E., Spiegelman, D., & Curhan, G. C. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-6-200303180-00009 · Cited by 426 · see citing works
Wiggins, J. E., Goyal, M., Sanden, S. K., Wharram, B. L., Shedden, K. A., Misek, D. E., Kuick, R. D., & Wiggins, R. C. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005050488 · Cited by 418 · see citing works
Glover, E. I., Phillips, S. M., Oates, B. R., Tang, J. E., Tarnopolsky, M. A., Selby, A., Smith, K., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160333 · Cited by 414 · see citing works
Breen, L., Stokes, K. A., Churchward-Venne, T. A., Moore, D. R., Baker, S. K., Smith, K., Atherton, P. J., & Phillips, S. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1502 · Cited by 395 · see citing works
Anabolic Resistance of Muscle Protein Synthesis with Aging
Burd, N. A., Gorissen, S. H., & van Loon, L. J. C. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318292f3d5 · Cited by 384 · see citing works
Recent trends in chronic disease, impairment and disability among older adults in the United States
Hung, W. W., Ross, J. S., Boockvar, K. S., & Siu, A. L. (2011) · BMC Geriatrics · doi:10.1186/1471-2318-11-47 · Cited by 373 · see citing works
Fulgoni, V. L. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1554s · Cited by 369 · cited 1× · see citing works
“Compared to younger adults, older adults usually eat less, including less protein [4,5].”
BackgroundVolpi, E., Campbell, W., Dwyer, J., Johnson, M., Jensen, G., Morley, J., & Wolfe, R. (2013) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/gls229 · Cited by 361 · see citing works
Protein Intake and Incident Frailty in the Women's Health Initiative Observational Study
Beasley, J. M., LaCroix, A. Z., Neuhouser, M. L., Huang, Y., Tinker, L., Woods, N., Michael, Y., Curb, J. D., & Prentice, R. L. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02866.x · Cited by 337 · see citing works
Burd, N. A., West, D. W. D., Moore, D. R., Atherton, P. J., Staples, A. W., Prior, T., Tang, J. E., Rennie, M. J., Baker, S. K., & Phillips, S. M. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135038 · Cited by 325 · see citing works
Tieland, M., Borgonjen-Van den Berg, K. J., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · European Journal of Nutrition · doi:10.1007/s00394-011-0203-6 · Cited by 297 · see citing works
Deutz, N. E. P., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.02.011 · Cited by 287 · see citing works
Self-citationLong-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
Verhoeven, S., Vanschoonbeek, K., Verdijk, L., Koopman, R., Wodzig, W., Dendale, P., & van Loon, L. V. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26668 · Cited by 286 · see citing works
Protein pulse feeding improves protein retention in elderly women
Arnal, M.-A., Mosoni, L., Boirie, Y., Houlier, M.-L., Morin, L., Verdier, E., Ritz, P., Antoine, J.-M., Prugnaud, J., Beaufrère, B., et al. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1202 · Cited by 284 · see citing works
Self-citationEffect of amino acid supplementation on muscle mass, strength and physical function in elderly.
Børsheim, E., Bui, Q.-U. T., Tissier, S., Kobayashi, H., Ferrando, A., & Wolfe, R. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.01.001 · Cited by 282 · see citing works
Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise
Balagopal, P., Coenen-Schimke, J. M., Ades, P. A., Adey, D., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e203 · Cited by 248 · see citing works
Self-citationPhysiopathological Mechanism of Sarcopenia
Walrand, S., Guillet, C., Salles, J., Cano, N., & Boirie, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.005 · Cited by 235 · cited 1× · see citing works
“Nutrition in combination with exercise is considered optimal for maintaining muscle function [3].”
BackgroundSelf-citationScott, D., Blizzard, L., Fell, J., Giles, G., & Jones, G. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03147.x · Cited by 228 · see citing works
Nutritional strategies to attenuate muscle disuse atrophy
Wall, B. T., & van Loon, L. J. (2013) · Nutrition Reviews · doi:10.1111/nure.12019 · Cited by 228 · see citing works
Increasing Dietary Protein Requirements in Elderly People for Optimal Muscle and Bone Health
Gaffney‐Stomberg, E., Insogna, K. L., Rodriguez, N. R., & Kerstetter, J. E. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02285.x · Cited by 226 · see citing works
Physiopathological mechanism of sarcopenia
Boirie, Y. (2009) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0203-x · Cited by 203 · see citing works
Self-citationDietary protein and muscle in older persons
Paddon-Jones, D., & Leidy, H. (2014) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000011 · Cited by 199 · see citing works
Frisoli, A., Chaves, P. H. M., Ingham, S. J. M., & Fried, L. P. (2010) · Bone · doi:10.1016/j.bone.2010.12.025 · Cited by 195 · see citing works
Reitelseder, S., Agergaard, J., Doessing, S., Helmark, I. C., Lund, P., Kristensen, N. B., Frystyk, J., Flyvbjerg, A., Schjerling, P., van Hall, G., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2010 · Cited by 190 · see citing works
Boirie, Y., Gachon, P., Corny, S., Fauquant, J., Maubois, J. L., & Beaufrere, B. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.6.e1083 · Cited by 174 · see citing works
Self-citationKoopman, R., Walrand, S., Beelen, M., Gijsen, A. P., Kies, A. K., Boirie, Y., Saris, W. H. M., & van Loon, L. J. C. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.109173 · Cited by 167 · see citing works
Self-citationLeenders, M., Verdijk, L. B., van der Hoeven, L., van Kranenburg, J. M. X., Hartgens, F., Wodzig, W. K. W. H., Saris, W. H. M., & van Loon, L. J. C. (2011) · Journal of Nutrition · doi:10.3945/jn.111.138495 · Cited by 159 · see citing works
Bouillanne, O., Curis, E., Hamon-Vilcot, B., Nicolis, I., Chrétien, P., Schauer, N., Vincent, J.-P., Cynober, L., & Aussel, C. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.015 · Cited by 152 · see citing works
Is there a maximal anabolic response to protein intake with a meal?
Deutz, N. E., & Wolfe, R. R. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.11.018 · Cited by 144 · see citing works
Self-citationAging and Chronic Kidney Disease
Nitta, K., Okada, K., Yanai, M., & TAKAHASHI, S. Y. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355760 · Cited by 143 · see citing works
Rémond, D., Machebeuf, M., Yven, C., Buffière, C., Mioche, L., Mosoni, L., & Mirand, P. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1286 · Cited by 141 · see citing works
Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle
Dickinson, J. M., Volpi, E., & Rasmussen, B. B. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a4e699 · Cited by 139 · see citing works
Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest
Biolo, G., Ciocchi, B., Stulle, M., Bosutti, A., Barazzoni, R., Zanetti, M., Antonione, R., Lebenstedt, M., Platen, P., Heer, M. A., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.366 · Cited by 139 · see citing works
Self-citationTimmerman, K. L., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Jennings, K., Rasmussen, B. B., & Volpi, E. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020800 · Cited by 138 · see citing works
Rennie, M. J. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-012 · Cited by 135 · see citing works
Bax, M.-L., Buffière, C., Hafnaoui, N., Gaudichon, C., Savary‐Auzeloux, I., Dardevet, D. P., Santé-Lhoutellier, V., & Rémond, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061252 · Cited by 128 · see citing works
Meng, X., Zhu, K., Devine, A., Kerr, D. A., Binns, C. W., & Prince, R. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090513 · Cited by 123 · see citing works
Impaired protein metabolism: interlinks between obesity, insulin resistance and inflammation
Guillet, C., Masgrau, A., Walrand, S., & Boirie, Y. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01037.x · Cited by 118 · see citing works
Self-citationBiomarker-Calibrated Protein Intake and Physical Function in the Women’s Health Initiative
Beasley, J. M., Wertheim, B., Lacroix, A. Z., Prentice, R., Neuhouser, M., Tinker, L., Kritchevsky, S., Shikany, J., Eaton, C., Chen, Z., et al. (2013) · Journal of The American Geriatrics Society · doi:10.1111/jgs.12503 · Cited by 114 · see citing works
Dideriksen, K., Reitelseder, S., & Holm, L. (2013) · Nutrients · doi:10.3390/nu5030852 · Cited by 110 · see citing works
Marchesini, G., Zoli, M., Dondi, C., Bianchi, G., Cirulli, M., & Pisi, E. (1982) · Hepatology · doi:10.1002/hep.1840020405 · Cited by 99 · see citing works
Optimizing protein intake in aging
Walrand, S., & Boirie, Y. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200501000-00014 · Cited by 99 · see citing works
Self-citationEfficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations
Fitschen, P. J., Wilson, G. J., Wilson, J. M., & Wilund, K. R. (2013) · Nutrition · doi:10.1016/j.nut.2012.05.005 · Cited by 97 · see citing works
Health effects of protein intake in healthy elderly populations: a systematic literature review
Pedersen, A. N., & Cederholm, T. (2014) · Food & Nutrition Research · doi:10.3402/fnr.v58.23364 · Cited by 93 · see citing works
Self-citationTang, M., McCabe, G. P., Elango, R., Pencharz, P. B., Ball, R. O., & Campbell, W. W. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042325 · Cited by 92 · see citing works
Ozaki, A., Uchiyama, M., Tagaya, H., Ohida, T., & Ogihara, R. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.01019.x · Cited by 86 · see citing works
Protein feeding pattern does not affect protein retention in young women
Mosoni, L., Mirand, P. P., Arnal, M.-A., Boirie, Y., Morin, L., Houlier, M.-L., Verdier, E., Ritz, P., Antoine, J.-M., Prugnaud, J., et al. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.7.1700 · Cited by 78 · see citing works
Self-citationProtein intake and muscle strength in older persons: does inflammation matter?
Bartali, B., Frongillo, E. A., Stipanuk, M. H., Bandinelli, S., Salvini, S., Palli, D., Morais, J. A., Volpato, S., Guralnik, J. M., & Ferrucci, L. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03833.x · Cited by 76 · see citing works
Sarcopenia: A useful paradigm for physical frailty
Cruz-Jentoft, A., & Michel, J. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2013.02.009 · Cited by 76 · see citing works
Self-citationSchautz, B., Later, W., Heller, M., Müller, M. J., & Bosy-Westphal, A. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.138 · Cited by 74 · see citing works
Self-citationSarcopenic Obesity: Strategies for Management
Benton, M. J., Whyte, M. D., & Dyal, B. W. (2011) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000408184.21770.98 · Cited by 71 · see citing works
Protein intake protects against weight loss in healthy community-dwelling older adults.
Gray-donald, K., St-Arnaud-Mckenzie, D., Gaudreau, P., Morais, J., Shatenstein, B., & Payette, H. (2014) · Journal of NutriLife · doi:10.3945/jn.113.184705 · Cited by 71 · see citing works
Promoting access to innovation for frail old persons
Berrut, G., Andrieu, S., de Carvalho, I. A., Baeyens, J., Bergman, H., Cassim, B., Cerreta, F., Cesari, M., Cha, H. B., Chen, L., et al. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0039-2 · Cited by 66 · see citing works
Self-citationChronic Kidney Disease in the Elderly
Maw, T. T., & Fried, L. F. (2013) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2013.05.003 · Cited by 65 · see citing works
Are Elderly Hospitalized Patients Getting Enough Protein?
Gaillard, C., Alix, E., Boirie, Y., Berrut, G., & Ritz, P. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01721.x · Cited by 52 · see citing works
Self-citationDietary protein and exercise training in ageing
Koopman, R. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110003927 · Cited by 50 · see citing works
Breen, L., Philp, A., Shaw, C. S., Jeukendrup, A. E., Baar, K., & Tipton, K. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020613 · Cited by 41 · see citing works
Self-citation(2001) · PubMed · Cited by 35 · see citing works
Biolo, G., De Cicco, M., Dal Mas, V., Lorenzon, S., Antonione, R., Ciocchi, B., Barazzoni, R., Zanetti, M., Dore, F., & Guarnieri, G. (2006) · Nutrition · doi:10.1016/j.nut.2005.11.003 · Cited by 26 · see citing works
Self-citationBeasley, J. M., Aragaki, A. K., LaCroix, A. Z., Neuhouser, M. L., Tinker, L. F., Cauley, J. A., Ensrud, K. E., Jackson, R. D., & Prentice, R. L. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135814 · Cited by 26 · see citing works
Is There a Physiologic Basis for Creatine Use in Children and Adolescents?
UNNITHAN, V. B., VEEHOF, S. H. E., VELLA, C. A., & KERN, M. (2001) · Journal of Strength and Conditioning Research · doi:10.1519/00124278-200111000-00021 · Cited by 18 · see citing works
Elderly Persons With ICU‐Acquired Weakness
Rahman, A., Wilund, K. R., Fitschen, P. J., Jeejeebhoy, K. N., Agarwala, R., Drover, J., & Mourtzakis, M. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113502545 · Cited by 15 · see citing works
Epidemiology of Muscle Mass Loss with Age
Visser, M. (2012) · doi:10.1002/9781118338032.ch1 · Cited by 15 · see citing works
Flagged first, then by citations
4 of the 99 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905 · see citing works
Self-citationESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Self-citationESPEN guidelines on nutrition in cancer patients
Arends, J., Bachmann, P., Baracos, V., Barthelemy, N., Bertz, H., Bozzetti, F., Fearon, K., Hütterer, E., Isenring, E., Kaasa, S., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.07.015 · Cited by 3,114 · see citing works
ESPEN guidelines on definitions and terminology of clinical nutrition
Cederholm, T., Barazzoni, R., Austin, P., Ballmer, P., Biolo, G., Bischoff, S. C., Compher, C., Correia, I., Higashiguchi, T., Holst, M., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.004 · Cited by 2,560 · see citing works
Self-citationESPEN guideline on clinical nutrition and hydration in geriatrics
Volkert, D., Beck, A. M., Cederholm, T., Cruz-Jentoft, A., Goisser, S., Hooper, L., Kiesswetter, E., Maggio, M., Raynaud-Simon, A., Sieber, C. C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.05.024 · Cited by 1,505 · see citing works
Self-citationHypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448 · see citing works
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130 · see citing works
Self-citationSkeletal muscle performance and ageing
Tieland, M., Trouwborst, I., & Clark, B. C. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12238 · Cited by 904 · see citing works
Malnutrition in Older Adults—Recent Advances and Remaining Challenges
Norman, K., Haß, U., & Pirlich, M. (2021) · Nutrients · doi:10.3390/nu13082764 · Cited by 775 · see citing works
Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.021 · Cited by 670 · see citing works
Self-citationSarcopenia and Cardiovascular Diseases
Damluji, A. A., Alfaraidhy, M., AlHajri, N., Rohant, N. N., Kumar, M., Al Malouf, C., Bahrainy, S., Ji Kwak, M., Batchelor, W. B., Forman, D. E., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064071 · Cited by 645 · see citing works
Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease
Argilés, J. M., Campos, N., Lopez-Pedrosa, J. M., Rueda, R., & Rodriguez-Mañas, L. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.04.019 · Cited by 581 · see citing works
Osteosarcopenia: where bone, muscle, and fat collide
Hirschfeld, H. P., Kinsella, R., & Duque, G. (2017) · Osteoporosis International · doi:10.1007/s00198-017-4151-8 · Cited by 534 · see citing works
ESPEN practical guideline: Clinical nutrition and hydration in geriatrics
Volkert, D., Beck, A. M., Cederholm, T., Cruz-Jentoft, A., Hooper, L., Kiesswetter, E., Maggio, M., Raynaud-Simon, A., Sieber, C., Sobotka, L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.01.024 · Cited by 516 · see citing works
Self-citationSarcopenia in chronic kidney disease: what have we learned so far?
Sabatino, A., Cuppari, L., Stenvinkel, P., Lindholm, B., & Avesani, C. M. (2020) · Journal of Nephrology · doi:10.1007/s40620-020-00840-y · Cited by 524 · see citing works
ESPEN guideline clinical nutrition in neurology
Burgos, R., Bretón, I., Cereda, E., Desport, J. C., Dziewas, R., Genton, L., Gomes, F., Jésus, P., Leischker, A., Muscaritoli, M., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.003 · Cited by 571 · see citing works
Self-citationFish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults
Smith, G. I., Julliand, S., Reeds, D. N., Sinacore, D. R., Klein, S., & Mittendorfer, B. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105833 · Cited by 507 · see citing works
Nutrition, frailty, and sarcopenia
Cruz-Jentoft, A. J., Kiesswetter, E., Drey, M., & Sieber, C. C. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0709-0 · Cited by 488 · see citing works
Self-citationDoes nutrition play a role in the prevention and management of sarcopenia?
Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.016 · Cited by 491 · see citing works
Self-citationDietary Protein and Amino Acids in Vegetarian Diets—A Review
Mariotti, F., & Gardner, C. (2019) · Nutrients · doi:10.3390/nu11112661 · Cited by 370 · see citing works
Ticinesi, A., Lauretani, F., Milani, C., Nouvenne, A., Tana, C., Del Rio, D., Maggio, M., Ventura, M., & Meschi, T. (2017) · Nutrients · doi:10.3390/nu9121303 · Cited by 401 · see citing works
Protein "requirements" beyond the RDA: implications for optimizing health
Phillips, S. M., Chevalier, S., & Leidy, H. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0550 · Cited by 396 · see citing works
Nutrition interventions to treat low muscle mass in cancer
Prado, C. M. M., Purcell, S. A., & Laviano, A. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12525 · Cited by 395 · see citing works
Sayer, A. A., Cooper, R., Arai, H., Cawthon, P. M., Essomba, M.-J. N., Fielding, R. A., Grounds, M. D., Witham, M. D., & Cruz-Jentoft, A. J. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00550-w · Cited by 395 · see citing works
Self-citationMuscle and bone, two interconnected tissues
Tagliaferri, C., Wittrant, Y., Davicco, M.-J., Walrand, S., & Coxam, V. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.002 · Cited by 394 · see citing works
Tournadre, A., Vial, G., Capel, F., Soubrier, M., & Boirie, Y. (2019) · Joint Bone Spine · doi:10.1016/j.jbspin.2018.08.001 · Cited by 375 · see citing works
Self-citationLonnie, M., Hooker, E., Brunstrom, J. M., Corfe, B. M., Green, M. A., Watson, A., Williams, E. A., Stevenson, E., Penson, S., & Johnstone, A. M. (2018) · Nutrients · doi:10.3390/nu10030360 · Cited by 362 · see citing works
Sieber, C. C. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01170-1 · Cited by 356 · see citing works
Ligthart-Melis, G., Luiking, Y., Kakourou, A., Cederholm, T., Maier, A., & de van der Schueren, M. D. V. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.03.006 · Cited by 313 · see citing works
Self-citationSarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355 · see citing works
Supplemental protein in support of muscle mass and health: advantage whey.
Devries, M., & Phillips, S. M. (2015) · Journal of Food Science · doi:10.1111/1750-3841.12802 · Cited by 318 · see citing works
Rémond, D., Shahar, D., Gille, D., Pinto, P., Kachal, J., Peyron, M., dos Santos, C. D., Walther, B., Bordoni, A., Dupont, D., et al. (2015) · OncoTarget · doi:10.18632/oncotarget.4030 · Cited by 299 · see citing works
The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals
Craig, W. J., Mangels, A. R., Fresán, U., Marsh, K. A., Miles, F. L., Saunders, A. V., Haddad, E. H., Heskey, C. E., JOHNSTON, P. K., Larson‐Meyer, E., et al. (2021) · Nutrients · doi:10.3390/nu13114144 · Cited by 342 · see citing works
Dedeyne, L., Deschodt, M., Verschueren, S., Tournoy, J., & Gielen, E. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s130794 · Cited by 315 · see citing works
Economic Impact of Hospitalizations in US Adults with Sarcopenia
Goates, S., Du, K., Arensberg, M. B., Gaillard, T. R., Guralnik, J. M., & Pereira, S. L. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.10 · Cited by 301 · see citing works
Poor Oral Health as a Determinant of Malnutrition and Sarcopenia
Azzolino, D., Passarelli, P. C., Angelis, P. D., Piccirillo, G. B., D’Addona, A., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11122898 · Cited by 292 · see citing works
JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease
Makita, S., Yasu, T., Akashi, Y. J., Adachi, H., Izawa, H., Ishihara, S., Iso, Y., Ohuchi, H., Omiya, K., Ohya, Y., et al. (2022) · Circulation Journal · doi:10.1253/circj.cj-22-0234 · Cited by 296 · see citing works
Gielen, E., Beckwée, D., Delaere, A., De Breucker, S., Vandewoude, M., Bautmans, I., the Sarcopenia Guidelines Development Group of the Belgian Society of Gerontology and Geriatrics (BSGG), Bautmans, I., Beaudart, C., Beckwée, D., et al. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuaa011 · Cited by 269 · see citing works
Verlaan, S., Aspray, T. J., Bauer, J. M., Cederholm, T., Hemsworth, J., Hill, T. R., McPhee, J. S., Piasecki, M., Seal, C., Sieber, C. C., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2015.11.013 · Cited by 268 · see citing works
Self-citationESPEN guideline on hospital nutrition
Thibault, R., Abbasoglu, O., Ioannou, E., Meija, L., Ottens-Oussoren, K., Pichard, C., Rothenberg, E., Rubin, D., Siljamäki-Ojansuu, U., Vaillant, M.-F., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.09.039 · Cited by 259 · see citing works
Rizzoli, R., Stevenson, J. C., Bauer, J. M., van Loon, L. J. C., Walrand, S., Kanis, J. A., Cooper, C., Brandi, M.-L., Diez-Perez, A., & Reginster, J.-Y. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.07.005 · Cited by 291 · see citing works
Self-citationSarcopenia in the Older Adult With Cancer
Williams, G. R., Dunne, R. F., Giri, S., Shachar, S. S., & Caan, B. J. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00102 · Cited by 251 · see citing works
Sarcopenic obesity: time to meet the challenge
Barazzoni, R., Bischoff, S. C., Boirie, Y., Busetto, L., Cederholm, T., Dicker, D., Toplak, H., Van Gossum, A., Yumuk, V., & Vettor, R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.018 · Cited by 260 · see citing works
Self-citationThe role of nutrition in inflammaging
Giosia, P. D., Stamerra, C. A., Giorgini, P., Jamialahamdi, T., Butler, A. E., & Sahebkar, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101596 · Cited by 250 · see citing works
Billot, M., Calvani, R., Urtamo, A., Sánchez-Sánchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, M. N., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s253535 · Cited by 242 · see citing works
Sarcopenic obesity: time to meet the challenge
Barazzoni, R., Bischoff, S., Boirie, Y., Busetto, L., Cederholm, T., Dicker, D., Toplak, H., Van Gossum, A., Yumuk, V., & Vettor, R. (2018) · Obesity Facts · doi:10.1159/000490361 · Cited by 244 · see citing works
Self-citationPapadopoulou, S. Κ., Papadimitriou, K., Voulgaridou, G., Georgaki, E., Tsotidou, E., Zantidou, O., & Papandreou, D. (2021) · Nutrients · doi:10.3390/nu13124499 · Cited by 245 · see citing works
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Obesity and cardiovascular health
Welsh, A., Hammad, M., Piña, I. L., & Kulinski, J. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae025 · Cited by 239 · see citing works
Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults
Granic, A., Sayer, A. A., & Robinson, S. M. (2019) · Nutrients · doi:10.3390/nu11040745 · Cited by 217 · see citing works
Loenneke, J. P., Loprinzi, P. D., Murphy, C. H., & Phillips, S. M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.04.002 · Cited by 208 · see citing works
Protein intake and muscle function in older adults
Deer, R. R., & Volpi, E. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000162 · Cited by 206 · see citing works
Plant-Based Meats, Human Health, and Climate Change
van Vliet, S., Kronberg, S. L., & Provenza, F. D. (2020) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2020.00128 · Cited by 207 · see citing works
Park, Y., Choi, J.-E., & Hwang, H.-S. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy214 · Cited by 193 · see citing works
Yoshimura, Y., Bise, T., Shimazu, S., Tanoue, M., Tomioka, Y., Araki, M., Nishino, T., Kuzuhara, A., & Takatsuki, F. (2018) · Nutrition · doi:10.1016/j.nut.2018.05.028 · Cited by 193 · see citing works
The Underappreciated Role of Low Muscle Mass in the Management of Malnutrition
Deutz, N. E. P., Ashurst, I., Ballesteros-Pomar, M. D., Bear, D. E., Cruz-Jentoft, A. J., Genton, L., Landi, F., Laviano, A., Norman, K., & Prado, C. M. M. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.11.021 · Cited by 193 · see citing works
Self-citationColetta, G., & Phillips, S. M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101883 · Cited by 207 · see citing works
Liao, C.-D., Chen, H.-C., Huang, S.-W., & Liou, T.-H. (2019) · Nutrients · doi:10.3390/nu11081713 · Cited by 189 · see citing works
Physical activity and incidence of sarcopenia: the population-based AGES—Reykjavik Study
Mijnarends, D. M., Koster, A., Schols, J. M. G. A., Meijers, J. M. M., Halfens, R. J. G., Gudnason, V. G., Eiríksdóttir, G., Siggeirsdóttir, K., Sigurdsson, S. O., Jónsson, P. V., et al. (2016) · Age and Ageing · doi:10.1093/ageing/afw090 · Cited by 189 · see citing works
Rooks, D., Swan, T., Goswami, B., Filosa, L. A., Bunte, O., Panchaud, N., Coleman, L. A., Miller, R. R., Garcia Garayoa, E., Praestgaard, J., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.20836 · Cited by 177 · see citing works
McLean, R. R., Mangano, K. M., Hannan, M. T., Kiel, D. P., & Sahni, S. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv184 · Cited by 175 · see citing works
Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 181 · see citing works
The impact of protein quality on the promotion of resistance exercise-induced changes in muscle mass
Phillips, S. M. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0124-8 · Cited by 168 · see citing works
Clegg, M., Ribes, A. T., Reynolds, R., Kliem, K. E., & Stergiadis, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110586 · Cited by 173 · see citing works
Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements
Stefaniak, O., Dobrzyńska, M., Drzymała-Czyż, S., & Przysławski, J. (2022) · Nutrients · doi:10.3390/nu14214564 · Cited by 177 · see citing works
Wu, P.-Y., Huang, K.-S., Chen, K.-M., Chou, C.-P., & Tu, Y.-K. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.12.009 · Cited by 168 · see citing works
Isanejad, M., Mursu, J., Sirola, J., Kröger, H., Rikkonen, T., Tuppurainen, M., & Erkkila, A. (2016) · British Journal of Nutrition · doi:10.1017/s000711451600012x · Cited by 171 · see citing works
Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis
Bennett, J. L., Pratt, A. G., Dodds, R. M., Sayer, A. A., & Isaacs, J. D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00921-9 · Cited by 166 · see citing works
Rizzoli, R., Biver, E., Bonjour, J.-P., Coxam, V., Goltzman, D., Kanis, J. A., Lappe, J., Rejnmark, L., Sahni, S., Weaver, C., et al. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4534-5 · Cited by 164 · see citing works
Cramer, J. T., Cruz-Jentoft, A. J., Landi, F., Hickson, M., Zamboni, M. M., Pereira, S. L., Hustead, D. S., & Mustad, V. A. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.08.009 · Cited by 164 · see citing works
Self-citationThe Health Benefits of Egg Protein
Puglisi, M., & Fernández, M. (2022) · Nutrients · doi:10.3390/nu14142904 · Cited by 157 · see citing works
Weight loss strategies and the risk of skeletal muscle mass loss
McCarthy, D., & Berg, A. (2021) · Nutrients · doi:10.3390/nu13072473 · Cited by 163 · see citing works
The metabolomics of human aging: Advances, challenges, and opportunities
Panyard, D. J., Yu, B., & Snyder, M. P. (2022) · Science Advances · doi:10.1126/sciadv.add6155 · Cited by 155 · see citing works
Freiberger, E., Goisser, S., Porzel, S., Volkert, D., Kemmler, W., Sieber, C., & Bollheimer, C. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s82454 · Cited by 162 · see citing works
Verlaan, S., Maier, A. B., Bauer, J. M., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M. G., McMurdo, M. E. T., Mets, T. F., Seal, C. J., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.01.005 · Cited by 160 · see citing works
Self-citationNardone, O. M., de Sire, R., Petito, V., Testa, A., Villani, G., Scaldaferri, F., & Castiglione, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.694217 · Cited by 159 · see citing works
Englund, D. A., Kirn, D. R., Koochek, A., Zhu, H., Travison, T. G., Reid, K. F., von Berens, Å., Melin, M., Cederholm, T., Gustafsson, T., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx141 · Cited by 151 · see citing works
Self-citationRevised Reference Values for the Intake of Protein
Richter, M., Baerlocher, K. E., Bauer, J. M., Elmadfa, I., Heseker, H., Leschik‐Bonnet, E., Stangl, G. I., Volkert, D., Stehle, P., & on behalf of the German Nutrition Society (DGE) (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000499374 · Cited by 152 · see citing works
Self-citationAgostini, D., Donati Zeppa, S., Lucertini, F., Annibalini, G., Gervasi, M., Ferri Marini, C., Piccoli, G., Stocchi, V., Barbieri, E., & Sestili, P. (2018) · Nutrients · doi:10.3390/nu10081103 · Cited by 151 · see citing works
Nutritional support in chronic obstructive pulmonary disease (COPD): an evidence update
Collins, P. F., Yang, I. A., Chang, Y.-C., & Vaughan, A. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.41 · Cited by 148 · see citing works
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.002 · Cited by 150 · see citing works
Piccoli, G. B., Cederholm, T., Avesani, C. M., Bakker, S. J. L., Bellizzi, V., Cuerda, C., Cupisti, A., Sabatino, A., Schneider, S. M., Torreggiani, M., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.018 · Cited by 153 · see citing works
Self-citationCurrent Concepts and Unresolved Questions in Dietary Protein Requirements and Supplements in Adults
Phillips, S. M. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00013 · Cited by 145 · see citing works
Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity
Mechanick, J. I., Butsch, W. S., Christensen, S. M., Hamdy, O., Li, Z., Prado, C. M., & Heymsfield, S. B. (2025) · Obesity Reviews · doi:10.1111/obr.13841 · Cited by 149 · see citing works
Diet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 153 · see citing works
Optimizing nutrition in older people.
Clegg, M., & Williams, E. A. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.04.001 · Cited by 120 · see citing works
Frailty, nutrition-related parameters, and mortality across the adult age spectrum
Jayanama, K., Theou, O., Blodgett, J. M., Cahill, L. E., & Rockwood, K. J. (2018) · BMC Medicine · doi:10.1186/s12916-018-1176-6 · Cited by 140 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Lochlainn, M. N., Bowyer, R. C. E., & Steves, C. J. (2018) · Nutrients · doi:10.3390/nu10070929 · Cited by 138 · see citing works
Farsijani, S., Morais, J. A., Payette, H., Gaudreau, P., Shatenstein, B., Gray-Donald, K., & Chevalier, S. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.130716 · Cited by 136 · see citing works
Exercise and Protein Intake: A Synergistic Approach against Sarcopenia
Martone, A. M., Marzetti, E., Calvani, R., Picca, A., Tosato, M., Santoro, L., Giorgio, A. D., Nesci, A., Sisto, A., Santoliquido, A., et al. (2017) · BioMed Research International · doi:10.1155/2017/2672435 · Cited by 136 · see citing works
Rondanelli, M., Cereda, E., Klersy, C., Faliva, M. A., Peroni, G., Nichetti, M., Gasparri, C., Iannello, G., Spadaccini, D., Infantino, V., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12532 · Cited by 135 · see citing works
Impaired proteostasis during skeletal muscle aging
Fernando, R., Drescher, C., Nowotny, K., Grune, T., & Castro, J. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.037 · Cited by 134 · see citing works
Cow’s Milk Consumption and Health: A Health Professional’s Guide
Marangoni, F., Pellegrino, L., Verduci, E., Ghiselli, A., Bernabei, R., Calvani, R., Cetin, I., Giampietro, M., Perticone, F., Piretta, L., et al. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1491016 · Cited by 134 · see citing works
Murphy, C. H., Saddler, N. I., Devries, M. C., McGlory, C., Baker, S. K., & Phillips, S. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136424 · Cited by 133 · see citing works
Arends, J., Bertz, H., Bischoff, S., Fietkau, R., Herrmann, H. J., Holm, E., Horneber, M., Hütterer, E., Körber, J., Schmid, I., et al. (2015) · Aktuelle Ernährungsmedizin · doi:10.1055/s-0035-1552741 · Cited by 133 · see citing works
Tessier, A., & Chevalier, S. (2018) · Nutrients · doi:10.3390/nu10081099 · Cited by 132 · see citing works
Cruz-Jentoft, A. J., Dawson Hughes, B., Scott, D., Sanders, K. M., & Rizzoli, R. (2020) · Maturitas · doi:10.1016/j.maturitas.2019.11.007 · Cited by 144 · see citing works
Self-citationScreening, diagnosis and monitoring of sarcopenia: When to use which tool?
Ackermans, L. L. G. C., Rabou, J., Basrai, M., Schweinlin, A., Bischoff, S. C., Cussenot, O., Cancel‐Tassin, G., Renken, R. J., Gómez, E., González, P. S., et al. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.01.027 · Cited by 137 · see citing works
Lozano-Montoya, I., Correa-Pérez, A., Abraha, I., Soiza, R. L., Cherubini, A., O'Mahony, D., & Cruz-Jentoft, A. J. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s132496 · Cited by 130 · see citing works
Self-citation
- Authors
- Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., Singer, P., Teta, D., Tipton, K., & Calder, P. C.
- Affiliations
- Texas A&M University (US)
- Carl von Ossietzky Universität Oldenburg (DE)
- University of Trieste (IT)
- Uppsala University (SE)
- Hospital Universitario Ramón y Cajal (ES)
- Mayo Clinic (US)
- Tel Aviv University (IL)
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Stirling (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Corresponding author
- Deutz, Nicolaas E.P.
- ORCID
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 33
- Issue
- 6
- Pages
- 929-936
- ISSN
- 0261-5614 (ISSN-L)
- PMC
- PMC4208946
- OpenAlex
- W2029230411
- Cited by
- 1,738
- References
- 99
- Citations by year
- 2026: 211 · 2025: 175 · 2024: 159 · 2023: 195 · 2022: 151 · 2021: 159 · 2020: 191 · 2019: 144 · 2018: 130 · 2017: 87 · 2016: 66 · 2015: 57 · 2014: 8 · 2013: 2 · 2012: 1
- FWCI
- 47.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- IRIS (submittedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
- ePrints Soton (University of Southampton) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (UL1TR000135)
- National Heart, Lung, and Blood Institute (R01HL095903)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24DK100469)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- protein intake, sarcopenia, aging, older adults, resistance training, aerobic exercise, muscle strength, muscle mass, malnutrition, protein requirements, energy intake
- MeSH terms
- Aged, Aging, Energy Intake, Diet, Dietary Proteins, Humans, Nutritional Requirements, Protein-Energy Malnutrition, Exercise, Muscle, Skeletal, Muscle Strength, Sarcopenia, Recommended Dietary Allowances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
