Negative energy balance with exercise in identical twins: plasma glucose and insulin responses
Abstract
The effects of long-term (93 days) negative energy balance on plasma glucose and insulin were investigated by means of exercise with constant energy intake in seven pairs of young sedentary male identical twins. Results showed a significant decrease in fasting (-24%, P < 0.02) and postprandial insulin (-16%, P < 0.05). Fasting and postprandial plasma glucose and glucagon were not modified. Mean glucose disposal rate measured during a euglycemic-hyperinsulinemic clamp performed in five twin pairs was increased by 34% (P = 0.13). No significant intrapair similarity was found for the responses of fasting and postprandial insulin levels and of glucose disposal rate. Changes in glucose disposal rate were significantly greater in high compared with low losers for computerized tomography-measured abdominal visceral fat (3.0 +/- 1.1 vs. 0.3 +/- 0.5 mg x kg(-1) x min(-1), P < 0.05) despite similar losses in total body fat. We conclude that 1) a long-term negative energy balance generated by exercise training significantly reduces plasma insulin levels, whereas insulin sensitivity tends to be improved; 2) training-induced changes in insulin sensitivity are associated with changes in abdominal visceral fat; and 3) data from this experiment conducted with a small number of twin pairs suggest that the genotype does not seem to be a major determinant of the changes in insulin levels and sensitivity brought about by negative energy balance with exercise.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic makeup does not appear to strongly determine exercise-related changes in insulin levels and sensitivity under negative energy balance.
“Genotype is apparently not a major determinant of the changes in insulin levels and sensitivity brought about by negative energy balance with exercise (390)”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [390]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Long-term mild jogging increases insulin action despite no influence on body mass index or VO2 max
Oshida, Y., Yamanouchi, K., Hayamizu, S., & Sato, Y. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.5.2206 · Cited by 132 · see citing works
Effect of increased physical activity on voluntary intake in lean women
Woo, R., & Pi-Sunyer, X. (1985) · Metabolism · doi:10.1016/0026-0495(85)90108-8 · Cited by 85 · see citing works
Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins
Oppert, J., Nadeau, A., Tremblay, A., Després, J., Thériault, G., Dériaz, O., & Bouchard, C. (1995) · Metabolism · doi:10.1016/0026-0495(95)90295-3 · Cited by 66 · see citing works
Self-citationTremblay, A., Nadeau, A., Després, J., St-Jean, L., Thériault, G., & Bouchard, C. (1990) · PubMed · Cited by 42 · see citing works
Self-citationTremblay, A., Poehlman, E., Nadeau, A., Pérusse, L., & Bouchard, C. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011740 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00425.x · Cited by 397 · see citing works
Ryan, A. S. (2000) · Sports Medicine · doi:10.2165/00007256-200030050-00002 · Cited by 282 · see citing works
Ferguson, M., Gutin, B., Le, N., Karp, W. B., Litaker, M. S., Humphries, M. C., Okuyama, T., Riggs, S., & Owens, S. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800968 · Cited by 219 · see citing works
Interactions of Metabolic Hormones, Adipose Tissue and Exercise
McMurray, R. G., & Hackney, A. C. (2005) · Sports Medicine · doi:10.2165/00007256-200535050-00003 · Cited by 167 · see citing works
Age Related Shift in Visceral Fat.
Hunter, G. R., Gower, B. A., & Kane, B. (2010) · PubMed · Cited by 160 · see citing works
Exercise Training Prevents Regain of Visceral Fat for 1 Year Following Weight Loss
Hunter, G. R., Brock, D. W., Byrne, N. M., Chandler‐Laney, P. C., Del Corral, P., & Gower, B. A. (2010) · Obesity · doi:10.1038/oby.2009.316 · Cited by 136 · see citing works
Catecholamines and Obesity: Effects of Exercise and Training
Zouhal, H., Lemoine-Morel, S., Mathieu, M.-E., Casazza, G. A., & Jabbour, G. (2013) · Sports Medicine · doi:10.1007/s40279-013-0039-8 · Cited by 129 · see citing works
Dietary carbohydrates and insulin action in humans
Wolever, T. M. S. (2000) · British Journal of Nutrition · doi:10.1017/s0007114500001021 · Cited by 127 · see citing works
Causes of obesity: Looking beyond the hypothalamus
Peters, A., Pellerin, L., DALLMAN, M., Oltmanns, K. M., Schweiger, U., Jan Born, A., & Fehm, H. L. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.004 · Cited by 92 · see citing works
Exercise in aging: its important role in mortality, obesity and insulin resistance
Ryan, A. (2010) · Aging Health · doi:10.2217/ahe.10.46 · Cited by 84 · see citing works
Puberty as a life history transition
Ellison, P. T., Reiches, M. W., Shattuck-Faegre, H., Breakey, A., Konecna, M., Urlacher, S., & Wobber, V. (2012) · Annals of Human Biology · doi:10.3109/03014460.2012.693199 · Cited by 73 · see citing works
Pritchard, J., Després, J.-P., Gagnon, J., Tchernof, A., Nadeau, A., Tremblay, A., & Bouchard, C. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90125-7 · Cited by 62 · see citing works
Self-citationNutritional modulation of acute- and “chronic”-phase responses
Bengmark, S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00581-0 · Cited by 30 · see citing works
Huth, C., Pigeon, É., Riou, M.-È., St‐Onge, J., Arguin, H., Couillard, É., Dubois, M.-J., Marette, A., Tremblay, A., Weisnagel, S. J., et al. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-016-0488-2 · Cited by 27 · see citing works
Self-citationValidation of a simple index (SIisOGTT) of insulin sensitivity in a population of sedentary men
Pigeon, E., Riou, M. E., St-Onge, J., Couillard, E., Tremblay, A., Marette, A., Weisnagel, S. J., & Joanisse, D. R. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.04.007 · Cited by 16 · see citing works
Self-citationSong, A., Wang, C., Ren, L., & Zhao, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1738 · Cited by 15 · see citing works
Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men
Huth, C., Dubois, M.-J., Marette, A., Tremblay, A., Weisnagel, S. J., Lacaille, M., Mauriège, P., & Joanisse, D. R. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0402-3 · Cited by 11 · see citing works
Self-citationSmith, T. J., Schwarz, J., Montain, S. J., Rood, J. C., Pikosky, M. A., Castaneda‐Sceppa, C., Glickman, E. L., & Young, A. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-26 · Cited by 10 · see citing works
Ellison, P. T., & Reiches, M. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-383882-7.00004-0 · Cited by 9 · see citing works
Reiches, M. W., & Ellison, P. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822652-0.00014-6 · Cited by 6 · see citing works
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch12 · Cited by 1 · see citing works
The balance between exercise and diet: impact on insulin sensitivity
Chipkin, S. R., Black, S. E., & Braun, B. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.med.0000158152.47287.4e · Cited by 1 · see citing works
Papers Related to Obesity Surgery for 1997
Camilleri, A., & Deitel, M. (1998) · Obesity Surgery · doi:10.1381/096089298765554520
RELATIONSHIP BETWEEN CHANGES IN MAXIMAL AEROBIC CAPACITY AND METABOLIC PROFILES IN OBESE YOUTHS
Wellbery, L. M. (2003) · OhioLink ETD Center (Ohio Library and Information Network)
- Authors
- Oppert, J. M., Nadeau, A., Tremblay, A., Despres, J. P., Theriault, G., & Bouchard, C.
- Affiliations
- Hôtel-Dieu de Paris (FR)
- Nutrition Department, Hotel-Dieu Hospital, Paris, France.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1997-02-01
- Volume
- 272
- Issue
- 2
- Pages
- E248-E254
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2332235803
- Cited by
- 25
- References
- 5
- Citations by year
- 2021: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-34024)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- negative energy balance, exercise training, insulin sensitivity, plasma insulin, plasma glucose, glucose disposal rate, visceral fat, genotypes, monozygotic twins, weight loss, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Blood Glucose, Body Composition, Energy Metabolism, Humans, Insulin, Male, Physical Education and Training, Time Factors, Tomography, X-Ray Computed, Twins, Monozygotic, Viscera, Glucose Clamp Technique, Exercise
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
