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Cited by 109Muscle metabolism and nutritionClinical Nutrition and GastroenterologyTrauma, Hemostasis, Coagulopathy, Resuscitation

Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients

Mansoor, Odile, Cayol, Marc, Gachon, Pierre, Boirie, Yves, Schoeffler, Pierre, Obled, Christiane, Beaufrère, Bernard·1997·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1997.273.5.e898
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Abstract

The effect of trauma on protein metabolism was investigated in the whole body, muscle, and liver in severely head-injured patients presenting an acute inflammatory response by comparison to fed control subjects receiving a similar diet. Nonoxidative leucine disposal (an index of whole body protein synthesis) and muscle, albumin, and fibrinogen synthesis were determined by means of a primed, continuous infusion ofl-[1-13 C]leucine. Nonoxidative leucine disposal increased by 28% in the patients ( P < 0.02). Fractional muscle protein synthesis rate decreased by 50% ( P < 0.01) after injury. Fractional and absolute fribrinogen synthesis rates were multiplied by two and nine, respectively, after injury ( P< 0.001). Albumin levels were lower in patients (25.2 ± 1.2 g/l, means ± SE) than in controls (33.7 ± 1.2 g/l, P < 0.001). However, fractional albumin synthesis rates were increased by 60% in patients (11.4 ± 1.0%/day) compared with controls (7.3 ± 0.4%/day, P < 0.01). Therefore, 1) head trauma induces opposite and large changes of protein synthesis in muscle and acute-phase hepatic proteins, probably mediated by cytokines, glucocorticoids, and other stress hormones, and 2) in these patients, hypoalbuminemia is not due to a depressed albumin synthesis.

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Crossref · 10.1152/ajpendo.1997.273.5.e898

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  • In most disease states in which synthesis rates have been measured, fractional synthesis rate in plasma is normal or mildly increased.

    “However, in most disease states in which synthesis rates have been measured, fractional synthesis rate (FSR) in plasma has been reported to be normal or mildly increased (Table 1).63, 64, 65, 66, 67, 68, 69, 70, 71”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [67]

  • All acutely ill or surgically traumatized patients have low serum albumin levels.

    “In clinical practice, all acutely ill or (surgically) traumatized patients have low serum albumin levels.66, 67, 68, 69, 98, 99, 100”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [67]

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Authors
Mansoor, O., Cayol, M., Gachon, P., Boirie, Y., Schoeffler, P., Obled, C., & Beaufrère, B.
Affiliations
  • Université Clermont Auvergne (FR)
  • Institut National de la Recherche Agronomique (FR)
  • Laboratoire de Nutrition Humaine, Université d’Auvergne Centre de Recherche en Nutrition Humaine, 63009 Clermont-Ferrand, France
  • Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1997-11-01
Volume
273
Issue
5
Pages
E898-E902
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1997.273.5.e898
OpenAlex
W1962005150
Cited by
109
References
32
Citations by year
2026: 1 · 2023: 1 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
traumatic brain injury, protein synthesis, albumin synthesis, fibrinogen synthesis, muscle protein synthesis, hypoalbuminemia, acute phase response, hepatic protein synthesis, leucine infusion, cytokines, glucocorticoids, stress hormones, trauma-induced inflammation
MeSH terms
Blood Proteins, Calorimetry, Energy Metabolism, Fibrinogen, Craniocerebral Trauma, Humans, Leucine, Liver, Proteins, Reference Values, Serum Albumin, Muscle, Skeletal

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