Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin
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Background & aims To investigate the effects of glucose, parenteral amino acids, and intravenous insulin on albumin synthesis rates in critically ill children.Methods Two studies were performed in 8 post-surgical infants (age 9.8 ± 1.9 months; weight 9.5 ± 1.1 kg) and 9 septic adolescents (age 15 ± 1 yr; BMI 23 ± 4 kg m(-2)), respectively. All received a primed, constant, tracer infusion with [1-(13)C]Leucine. The infants in study 1 were randomized to receive low (2.5 mg kg(-1) min(-1)) and standard (5.0 mg kg(-1) min(-1)) glucose intake in a cross-over setting of two periods of 4 h each. The adolescents in study 2 were randomized to receive total parenteral nutrition with standard (1.5 g kg(-1) day(-1)) and high (3.0 g kg(-1) day(-1)) amino acid intake in a two day cross-over setting. On both study days, during the last 3 h of the tracer study, they received insulin infused at 80 mU m(-2) min(-1).Results The post-surgical infants and the septic adolescents were mildly hypoalbuminemic (∼2.5 g dL(-1)) with high synthesis rates, which were not affected by different intakes of glucose, amino acids, or insulin infusion.Conclusions Albumin synthesis rates in hypoalbuminemic critically ill children are high but were not upregulated through nutrient supply, and in septic adolescents are unaffected by insulin.
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In postsurgical or septic children and adolescents, fractional synthesis rates were high but did not increase after nutrition support.
“In postsurgical or septic children and adolescents, FSRs were high, but did not increase after nutrition support.77”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [77]
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Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448 · see citing works
Zhou, B., Ren, J., Han, G., Chen, Y., A, J., Gu, G., Chen, J., Wang, G., & Li, J. (2014) · Surgical Infections · doi:10.1089/sur.2012.144 · Cited by 7 · see citing works
- Authors
- Verbruggen, S. C., Schierbeek, H., Coss-Bu, J., Joosten, K. F. M., Castillo, L., & van Goudoever, J. B.
- Affiliations
- Baylor College of Medicine (US)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Children's Medical Center (US)
- Corresponding author
- Verbruggen, Sascha C.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 30
- Issue
- 4
- Pages
- 469-477
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2022181904
- Cited by
- 34
- References
- 54
- Citations by year
- 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Erasmus+
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- hypoalbuminemia, critically ill children, sepsis, adolescents, glucose ingestion, total parenteral nutrition, insulin infusion, leucine tracer
- MeSH terms
- Adolescent, Albumins, Amino Acids, Blood Glucose, Female, Glucose, Homeostasis, Humans, Hyperinsulinism, Infant, Insulin, Insulin Resistance, Leucine, Male, Parenteral Nutrition, Total, Intensive Care Units, Pediatric, Critical Illness, Cross-Over Studies, Sepsis
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