The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals
Abstract
We investigated prospectively the effect of sex steroids on regional fat depots and thigh muscle mass in adult transsexuals. Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was given to 20 male-to-female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. Before and after 12 mo of cross-sex hormone administration, several anthropometric measurements (weight, skinfolds, body circumferences, and bioimpedance) were performed, and transverse magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify fat depots (subcutaneous and visceral) and muscle areas. We observed that treatment with ethinyl estradiol in M-F transsexuals induced a significant increase in all subcutaneous fat depots, with a lesser but proportional and significant increase in the visceral fat depot and a decrease in thigh muscle area. Testosterone administration in F-M transsexuals markedly increased thigh muscle area, reduced subcutaneous fat deposition at all levels measured, but slightly increased the visceral fat area. We conclude that sex steroid hormones are important determinants of the sex-specific localization of body fat.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The first study42 reported a 9.5% decrease in quadriceps CSA compared with baseline after 12 months and an 11.7% decrease in quadriceps CSA compared with baseline after 36 months.”
In the citing paper
“There was only one study42 in which the limits of agreement indicated a change at the 95% CI.”
Citations
Cites
Assessment of fat-free mass using bioelectrical impedance measurements of the human body
Lukaski, H., Johnson, P., Bolonchuk, W., & Lykken, G. (1985) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/41.4.810 · Cited by 1,896
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., Bunnell, T. J., Tricker, R., Shirazi, A., & Casaburi, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350101 · Cited by 1,659
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
Kvist, H., Chowdhury, B., Grangård, U., Tylén, U., & Sjöström, L. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.6.1351 · Cited by 794
(1996) · PubMed · Cited by 643
Testosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men
Bhasin, S., Storer, T. W., Berman, N., Yarasheski, K. E., Clevenger, B., Phillips, J., Lee, W. P., Bunnell, T. J., & Casaburi, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3733 · Cited by 596
Sex differences in the relation of visceral adipose tissue accumulation to total body fatness
Lemieux, S., Prud’homme, D., Bouchard, C., Tremblay, A., & Després, J. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.463 · Cited by 570
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567
Self-citationThe effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Research works printed but not linked: 15
- Arslanian S., 1997, J. Clin. Endocrinol. Metab., 82, 3213
- Baumgartner R. N., 1986, Hum. Biol., 58, 719
- Bhasin S., 1997, J. Clin. Endocrinol. Metab., 82, 407
- Björkelund C., 1996, Int. J. Obes., 20, 213
- Björntorp P., 1996, Int. J. Obes., 20, 291
- Elbers J. M. H., 1997, J. Clin. Endocrinol. Metab., 82, 2044
- Elbers J. M. H., 1997, J. Clin. Endocrinol. Metab., 82, 3267
- Espeland M. A., 1997, J. Clin. Endocrinol. Metab., 82, 1549
- Evans D. J., 1988, Int. J. Obes., 12, 157
- Lovejoy J. C., 1996, J. Clin. Endocrinol. Metab., 81, 2198
- Lovejoy J. C., 1995, Int. J. Obes., 19, 614
- Mårin P., 1992, Int. J. Obes., 16, 991
- Mårin P., 1993, Int. J. Obes., 17, 83
- Rebuffé-Scrive M., 1991, Int. J. Obes., 15, 791
- Van Kesteren P. J. M., 1996, J. Clin. Endocrinol. Metab., 81, 2227
Cited by
Sorted by citations
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
Després, J.-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., Rodés-Cabau, J., Bertrand, O. F., & Poirier, P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159228 · Cited by 1,589
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Sex differences in human adipose tissues – the biology of pear shape
Karastergiou, K., Smith, S. R., Greenberg, A. S., & Fried, S. K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-13 · Cited by 1,109
Metadata
- Authors
- Elbers, J. M. H., Asscheman, H., Seidell, J. C., & Gooren, L. J. G.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- National Institute for Public Health and the Environment (NL)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-02-01
- Volume
- 276
- Issue
- 2
- Pages
- E317-E325
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2115643460
- Cited by
- 236
- References
- 45
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 6 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 11
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- sex hormones, transsexuals, gender-affirming hormone therapy, ethinyl estradiol, cyproterone acetate, testosterone esters, subcutaneous adipose tissue, visceral fat, thigh muscle mass
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Androgen Antagonists, Anthropometry, Drug Combinations, Ethinyl Estradiol, Female, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Sex Characteristics, Transsexualism, Cyproterone Acetate, Estradiol Congeners
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
