Cited by 236Hormonal and reproductive studiesLGBTQ Health, Identity, and PolicyBody Composition Measurement Techniques

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Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals

Elbers, J. M. H., Asscheman, H., Seidell, J. C., Gooren, L. J. G.·1999·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1999.276.2.e317

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Abstract

We investigated prospectively the effect of sex steroids on regional fat depots and thigh muscle mass in adult transsexuals. Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was given to 20 male-to-female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. Before and after 12 mo of cross-sex hormone administration, several anthropometric measurements (weight, skinfolds, body circumferences, and bioimpedance) were performed, and transverse magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify fat depots (subcutaneous and visceral) and muscle areas. We observed that treatment with ethinyl estradiol in M-F transsexuals induced a significant increase in all subcutaneous fat depots, with a lesser but proportional and significant increase in the visceral fat depot and a decrease in thigh muscle area. Testosterone administration in F-M transsexuals markedly increased thigh muscle area, reduced subcutaneous fat deposition at all levels measured, but slightly increased the visceral fat area. We conclude that sex steroid hormones are important determinants of the sex-specific localization of body fat.

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Assessment of fat-free mass using bioelectrical impedance measurements of the human body
Lukaski, H., Johnson, P., Bolonchuk, W., & Lykken, G. (1985) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/41.4.810 · Cited by 1,896
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., Bunnell, T. J., Tricker, R., Shirazi, A., & Casaburi, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350101 · Cited by 1,659
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations.
Kvist, H., Chowdhury, B., Grangård, U., Tylén, U., & Sjöström, L. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.6.1351 · Cited by 794
Untitled work
(1996) · PubMed · Cited by 643
Testosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men
Bhasin, S., Storer, T. W., Berman, N., Yarasheski, K. E., Clevenger, B., Phillips, J., Lee, W. P., Bunnell, T. J., & Casaburi, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3733 · Cited by 596
Sex differences in the relation of visceral adipose tissue accumulation to total body fatness
Lemieux, S., Prud’homme, D., Bouchard, C., Tremblay, A., & Després, J. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.463 · Cited by 570
Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567
Self-citation
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553

Show all 45 references

Research works printed but not linked: 15

Arslanian S., 1997, J. Clin. Endocrinol. Metab., 82, 3213
Baumgartner R. N., 1986, Hum. Biol., 58, 719
Bhasin S., 1997, J. Clin. Endocrinol. Metab., 82, 407
Björkelund C., 1996, Int. J. Obes., 20, 213
Björntorp P., 1996, Int. J. Obes., 20, 291
Elbers J. M. H., 1997, J. Clin. Endocrinol. Metab., 82, 2044
Elbers J. M. H., 1997, J. Clin. Endocrinol. Metab., 82, 3267
Espeland M. A., 1997, J. Clin. Endocrinol. Metab., 82, 1549
Evans D. J., 1988, Int. J. Obes., 12, 157
Lovejoy J. C., 1996, J. Clin. Endocrinol. Metab., 81, 2198
Lovejoy J. C., 1995, Int. J. Obes., 19, 614
Mårin P., 1992, Int. J. Obes., 16, 991
Mårin P., 1993, Int. J. Obes., 17, 83
Rebuffé-Scrive M., 1991, Int. J. Obes., 15, 791
Van Kesteren P. J. M., 1996, J. Clin. Endocrinol. Metab., 81, 2227

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Authors: Elbers, J. M. H., Asscheman, H., Seidell, J. C., & Gooren, L. J. G.
Affiliations: Vrije Universiteit Amsterdam (NL)
National Institute for Public Health and the Environment (NL)
ORCID: Seidell, J. C.
Gooren, L. J. G.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1999-02-01
Volume: 276
Issue: 2
Pages: E317-E325
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1999.276.2.e317
OpenAlex: W2115643460
Cited by: 236
References: 45
Citations by year: 2026: 4 · 2025: 14 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 6 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 11
FWCI: 3.23
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (submittedVersion)
Rivm (National Institute for Public Health and the Environment) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords: sex hormones, transsexuals, gender-affirming hormone therapy, ethinyl estradiol, cyproterone acetate, testosterone esters, subcutaneous adipose tissue, visceral fat, thigh muscle mass
MeSH terms: Adipose Tissue, Adolescent, Adult, Androgen Antagonists, Anthropometry, Drug Combinations, Ethinyl Estradiol, Female, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Sex Characteristics, Transsexualism, Cyproterone Acetate, Estradiol Congeners

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Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals

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