The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Neural contribution to the effect of glucagon-like peptide-1-(7—36) amide on arterial blood pressure in rats
Abstract
This study was designed to determine the contribution of the central nervous system (CNS) to the effects of glucagon-like peptide-1-(7—36) amide (tGLP-1) on arterial blood pressure and heart rate in rats. Accordingly, intracerebroventricular administration of the peptide produced an increase in cardiovascular parameters, which was blocked by previous administration of exendin-(9—39) through the same route, but not when it was intravenously injected. Intravenous administration of tGLP-1 produced a significant increase in arterial blood pressure and heart rate, which was blocked by the previous intracerebroventricular or intravenous administration of exendin-(9—39). Bilateral vagotomy blocked the stimulating effect of intracerebroventricular tGLP-1 administration on arterial blood pressure and heart rate. Also, bilateral vagotomy prevented the blocking effect of intracerebroventricular but not of intravenous exendin-(9—39) on cardiovascular parameters after intravenous administration of tGLP-1. These findings suggest that the action of tGLP-1 on cardiovascular parameters is under a dual control generated in the CNS and in peripheral structures and that the neural information emerging in the brain is transmitted to the periphery through the vagus nerve.
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“GLP-1 receptor agonists have dose-dependent chronotropic and pressor responses in rodents (5, 53)”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [5]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
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A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Glucagon-like peptide-1 7–36: a physiological incretin in man
Kreymann, B., Ghatei, M. A., Williams, G., & Bloom, S. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91194-9 · Cited by 1,928
Thorens, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8641 · Cited by 906
Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903
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Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man
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Hamster preproglucagon contains the sequence of glucagon and two related peptides
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Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
Tang-Christensen, M., Larsen, P. J., Goke, R., Fink-Jensen, A., Jessop, D. S., Moller, M., & Sheikh, S. P. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.4.r848 · Cited by 597
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Research works printed but not linked: 5
- Barragán J. M., 1994, Am. J. Physiol., 266, E459
- Cechetto D. F., 1987, Federation Proc., 46, 17
- Dunbar J. C., 1992, Am. J. Physiol., 262, R865
- Orskov C., 1995, Diabetologia, 8, A39
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Items 101–101 of 101
Aulinger, B., & D'Alessio, D. (2007) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328013e79e · Cited by 8
Metadata
- Authors
- Barragán, J. M., Eng, J., Rodríguez, R., & Blázquez, E.
- Affiliations
- Universidad de Salamanca (ES)
- Veterans Health Administration (US)
- Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain;
- Universidad Complutense de Madrid (ES)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-11-01
- Volume
- 277
- Issue
- 5
- Pages
- E784-E791
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2147973767
- Cited by
- 142
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 9
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- glucagon-like peptide-1(7-36)amide, arterial blood pressure, heart rate, central nervous system, exendin-9-39, vagotomy, vagus nerve, intracerebroventricular administration, intravenous administration, incretins
- MeSH terms
- Animals, Blood Pressure, Glucagon-Like Peptides, Glucagon, Heart Rate, Humans, Injections, Intravenous, Injections, Intraventricular, Male, Peptide Fragments, Peptides, Vagotomy, Vagus Nerve, Rats, Sprague-Dawley, Neurotransmitter Agents, Rats, Glucagon-Like Peptide 1
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