Cited by 142Neuropeptides and Animal PhysiologyDiabetes Treatment and ManagementHeart Rate Variability and Autonomic Control

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Neural contribution to the effect of glucagon-like peptide-1-(7—36) amide on arterial blood pressure in rats

Barragán, José Manuel, Eng, John, Rodríguez, Raquel, Blázquez, Enrique·1999·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1999.277.5.e784

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Abstract

This study was designed to determine the contribution of the central nervous system (CNS) to the effects of glucagon-like peptide-1-(7—36) amide (tGLP-1) on arterial blood pressure and heart rate in rats. Accordingly, intracerebroventricular administration of the peptide produced an increase in cardiovascular parameters, which was blocked by previous administration of exendin-(9—39) through the same route, but not when it was intravenously injected. Intravenous administration of tGLP-1 produced a significant increase in arterial blood pressure and heart rate, which was blocked by the previous intracerebroventricular or intravenous administration of exendin-(9—39). Bilateral vagotomy blocked the stimulating effect of intracerebroventricular tGLP-1 administration on arterial blood pressure and heart rate. Also, bilateral vagotomy prevented the blocking effect of intracerebroventricular but not of intravenous exendin-(9—39) on cardiovascular parameters after intravenous administration of tGLP-1. These findings suggest that the action of tGLP-1 on cardiovascular parameters is under a dual control generated in the CNS and in peripheral structures and that the neural information emerging in the brain is transmitted to the periphery through the vagus nerve.

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Authors: Barragán, J. M., Eng, J., Rodríguez, R., & Blázquez, E.
Affiliations: Universidad de Salamanca (ES)
Veterans Health Administration (US)
Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain;
Universidad Complutense de Madrid (ES)
ORCID: Eng, John
Blázquez, Enrique
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1999-11-01
Volume: 277
Issue: 5
Pages: E784-E791
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1999.277.5.e784
OpenAlex: W2147973767
Cited by: 142
References: 39
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: glucagon-like peptide-1(7-36)amide, arterial blood pressure, heart rate, central nervous system, exendin-9-39, vagotomy, vagus nerve, intracerebroventricular administration, intravenous administration, incretins
MeSH terms: Animals, Blood Pressure, Glucagon-Like Peptides, Glucagon, Heart Rate, Humans, Injections, Intravenous, Injections, Intraventricular, Male, Peptide Fragments, Peptides, Vagotomy, Vagus Nerve, Rats, Sprague-Dawley, Neurotransmitter Agents, Rats, Glucagon-Like Peptide 1

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Neural contribution to the effect of glucagon-like peptide-1-(7—36) amide on arterial blood pressure in rats

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