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Neural contribution to the effect of glucagon-like peptide-1-(7—36) amide on arterial blood pressure in rats
Abstract
This study was designed to determine the contribution of the central nervous system (CNS) to the effects of glucagon-like peptide-1-(7—36) amide (tGLP-1) on arterial blood pressure and heart rate in rats. Accordingly, intracerebroventricular administration of the peptide produced an increase in cardiovascular parameters, which was blocked by previous administration of exendin-(9—39) through the same route, but not when it was intravenously injected. Intravenous administration of tGLP-1 produced a significant increase in arterial blood pressure and heart rate, which was blocked by the previous intracerebroventricular or intravenous administration of exendin-(9—39). Bilateral vagotomy blocked the stimulating effect of intracerebroventricular tGLP-1 administration on arterial blood pressure and heart rate. Also, bilateral vagotomy prevented the blocking effect of intracerebroventricular but not of intravenous exendin-(9—39) on cardiovascular parameters after intravenous administration of tGLP-1. These findings suggest that the action of tGLP-1 on cardiovascular parameters is under a dual control generated in the CNS and in peripheral structures and that the neural information emerging in the brain is transmitted to the periphery through the vagus nerve.
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“GLP-1 receptor agonists have dose-dependent chronotropic and pressor responses in rodents (5, 53)”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [5]
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Metadata
- Authors
- Barragán, J. M., Eng, J., Rodríguez, R., & Blázquez, E.
- Affiliations
- Universidad de Salamanca (ES)
- Veterans Health Administration (US)
- Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain;
- Universidad Complutense de Madrid (ES)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-11-01
- Volume
- 277
- Issue
- 5
- Pages
- E784-E791
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2147973767
- Cited by
- 142
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 9
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- glucagon-like peptide-1(7-36)amide, arterial blood pressure, heart rate, central nervous system, exendin-9-39, vagotomy, vagus nerve, intracerebroventricular administration, intravenous administration, incretins
- MeSH terms
- Animals, Blood Pressure, Glucagon-Like Peptides, Glucagon, Heart Rate, Humans, Injections, Intravenous, Injections, Intraventricular, Male, Peptide Fragments, Peptides, Vagotomy, Vagus Nerve, Rats, Sprague-Dawley, Neurotransmitter Agents, Rats, Glucagon-Like Peptide 1
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