The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
Abstract
To investigate in vivo adipose tissue production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and their soluble receptors: TNF receptor type I (sTNFR-I), TNF receptor type II (sTNFR-II), and IL-6 receptor (sIL-6R), we determined arteriovenous differences in their levels across abdominal subcutaneous adipose tissue in obese subjects. Subjects had a median (interquartile range) age of 44.5 (27–51.3) yr, body mass index (BMI) of 32.9 (26.0–46.6) kg/m 2, and %body fat of 42.5 (28.5–51.2) %. Although there was not a significant difference in the arteriovenous concentrations of TNF-α ( P = 0.073) or sTNFR-II ( P = 0.18), the levels of sTNFR-I ( P = 0.002) were higher in the vein compared with artery, suggesting adipose tissue production of this soluble receptor. There was a significant arteriovenous difference in IL-6 ( P < 0.001) but not in its soluble receptor ( P = 0.18). There was no relationship between TNF-α levels and adiposity indexes ( r s= 0.12–0.22, P = not significant); however, levels of both its soluble receptor isomers correlated significantly with BMI and %body fat (sTNFR-I r s= 0.42–0.72, P < 0.001; sTNFR-II r s= 0.36–0.65, P < 0.05- <0.001). IL-6 levels correlated significantly with both BMI and %body fat ( r s= 0.51, P = 0.004, and r s= 0.63, P < 0.001), but sIL-6R did not. In conclusion, 1) soluble TNFR-I is produced by adipose tissue, and concentrations of both soluble isoforms correlate with the degree of adiposity, and 2) IL-6, but not its soluble receptor, is produced by adipose tissue and relates to adiposity.
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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Adipose tissue as an endocrine and paracrine organ
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Soluble cytokine receptors are present in normal human urine.
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Obesity and Cardiovascular Disease
Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.068 · Cited by 2,326
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Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of the Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259
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Fernández-Real, J. M., & Ricart, W. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0010 · Cited by 886
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Metadata
- Authors
- Mohamed-Ali, V., Goodrick, S., Bulmer, K., Holly, J. M. P., Yudkin, J. S., & Coppack, S. W.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-12-01
- Volume
- 277
- Issue
- 6
- Pages
- E971-E975
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2165240223
- Cited by
- 398
- References
- 25
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- closed
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