The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig
Abstract
Weaning in the piglet is a stressful event associated with gastrointestinal disorders and increased disease susceptibility. Although stress is thought to play a role in postweaning intestinal disease, the mechanisms by which stress influences intestinal pathophysiology in the weaned pig are not understood. The objectives of these experiments were to investigate the impact of weaning on gastrointestinal health in the pig and to assess the role of stress signaling pathways in this response. Nineteen-day-old pigs were weaned, and mucosal barrier function and ion transport were assessed in jejunal and colonic tissues mounted on Ussing chambers. Weaning caused marked disturbances in intestinal barrier function, as demonstrated by significant ( P < 0.01) reductions in transepithelial electrical resistance and increases in intestinal permeability to [ 3 H]mannitol in both the jejunum and colon compared with intestinal tissues from age-matched, unweaned control pigs. Weaned intestinal tissues exhibited increased intestinal secretory activity, as demonstrated by elevated short-circuit current that was sensitive to treatment with tetrodotoxin and indomethacin, suggesting activation of enteric neural and prostaglandin synthesis pathways in weaned intestinal tissues. Western blot analyses of mucosal homogenates showed increased expression of corticotrophin-releasing factor (CRF) receptor 1 in the jejunum and colon of weaned intestinal tissues. Pretreatment of pigs with the CRF receptor antagonist α-helical CRF(9–41), which was injected intraperitoneally 30 min prior to weaning, abolished the stress-induced mucosal changes. Our results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways.
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Mast Cell Tryptase Controls Paracellular Permeability of the Intestine
Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506338200 · Cited by 334
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
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Small Intestine Epithelial Barrier Function Is Compromised in Pigs with Low Feed Intake at Weaning
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Biologic Therapy for Inflammatory Bowel Disease
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Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
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“Rodent stress models have indicated that stress-induced alterations in intestinal function are mediated by the actions of corticotrophin-releasing factor (CRF) and subsequent activation of CRF receptors expressed locally in the gut (35, 37, 41).”
Background
Cited by
The biological stress of early weaned piglets
Campbell, J. M., Crenshaw, J. D., & Polo, J. (2013) · Journal of Animal Science and Biotechnology · doi:10.1186/2049-1891-4-19 · Cited by 1,014
Heo, J. M., Opapeju, F. O., Pluske, J. R., Kim, J. C., Hampson, D. J., & Nyachoti, C. M. (2013) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2012.01284.x · Cited by 769
Moeser, A. J., Pohl, C. S., & Rajput, M. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.06.003 · Cited by 452
“More importantly, administration of CRF receptor antagonists to early weaned pigs at weaning, or 9 weeks post-weaning, reduced the early (Moeser et al., 2007a) and chronic (Smith et al., 2010) elevations in intestinal permeability thus demonstrating a central role for the intestinal CRF receptor…”
BackgroundResultInfluentialGastrointestinal tract (gut) health in the young pig
Pluske, J. R., Turpin, D. L., & Kim, J.-C. (2018) · Animal Nutrition · doi:10.1016/j.aninu.2017.12.004 · Cited by 417
Keita, Å. V., & Söderholm, J. D. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01498.x · Cited by 286
Metadata
- Authors
- Moeser, A. J., Klok, C. V., Ryan, K. A., Wooten, J. G., Little, D., Cook, V. L., & Blikslager, A. T.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2007-01
- Volume
- 292
- Issue
- 1
- Pages
- G173-G181
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2128292675
- Cited by
- 316
- References
- 40
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moeser, A. J., Klok, C. V., Ryan, K. A., Wooten, J. G., Little, D., Cook, V. L., & Blikslager, A. T. (2007). Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00197.2006
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