Signalling pathways and transcriptional regulators orchestrating liver development and cancer

Hepatocellular carcinoma

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Hepatocellular Carcinoma

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Mechanisms of hepatic stellate cell activation

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Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

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Elucidation of a universal size-control mechanism in Drosophila and mammals

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Vascularized and functional human liver from an iPSC-derived organ bud transplant

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Hepatocellular Carcinoma.

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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

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Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

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Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

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A human liver cell atlas reveals heterogeneity and epithelial progenitors

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Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

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Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

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Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

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Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function

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Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

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Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.

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Hippo Pathway Activity Influences Liver Cell Fate

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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

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The role of signaling pathways in the development and treatment of hepatocellular carcinoma

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The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

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Organogenesis and development of the liver

Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.011 · Cited by 800 · see citing works

Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis

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Hepatic stellate cells in liver development, regeneration, and cancer

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Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endodermPreprint

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Multilineage communication regulates human liver bud development from pluripotency

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Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

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A bipotential precursor population for pancreas and liver within the embryonic endoderm

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Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

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The initiation of liver development is dependent on Foxa transcription factors

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Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

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Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

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Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

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Spatial heterogeneity in the mammalian liver

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Mammalian hepatocyte differentiation requires the transcription factor HNF-4αPreprint

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Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

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Fibrosis-dependent mechanisms of hepatocarcinogenesis

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Notch signaling controls liver development by regulating biliary differentiation

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Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of <i>Yap65</i>

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Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

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Hepatocyte migration during liver development requires Prox1

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Orchestrating liver development

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Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development

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Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factorsPreprint

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Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9

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The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

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Liver organoids: from basic research to therapeutic applications

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Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

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Production of hepatocyte-like cells from human pluripotent stem cells

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Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

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Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues

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Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

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Embryonic development of the liver†

Zhao, R., & Duncan, S. A. (2005) · Hepatology · doi:10.1002/hep.20691 · Cited by 292 · see citing works

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

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Plasticity and expanding complexity of the hepatic transcription factor network during liver development

Kyrmizi, I., Hatzis, P., Katrakili, N., Tronche, F., Gonzalez, F. J., & Talianidis, I. (2006) · Genes &amp; Development · doi:10.1101/gad.390906 · Cited by 285 · see citing works

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

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Oncofetal Gene <i>SALL4</i> in Aggressive Hepatocellular Carcinoma

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Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors

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YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

Fitamant, J., Kottakis, F., Benhamouche, S., Tian, H. S., Chuvin, N., Parachoniak, C. A., Nagle, J. M., Perera, R. M., Lapouge, M., Deshpande, V., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.027 · Cited by 248 · see citing works

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

Ang, L. T., Tan, A. K. Y., Autio, M. I., Goh, S. H., Choo, S. H., Lee, K. L., Tan, J., Pan, B., Lee, J. J. H., Lum, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.087 · Cited by 220 · see citing works

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

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Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways

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Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

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Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

Siller, R., Greenhough, S., Naumovska, E., & Sullivan, G. J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.04.001 · Cited by 203 · see citing works

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

Tan, X., Yuan, Y., Zeng, G., Apte, U., Thompson, M. D., Cieply, B., Stolz, D. B., Michalopoulos, G. K., Kaestner, K. H., & Monga, S. P. S. (2008) · Hepatology · doi:10.1002/hep.22225 · Cited by 202 · see citing works

Development of the mammalian liver and ventral pancreas is dependent on GATA4

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LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

Lee, D.-H., Park, J. O., Kim, T.-S., Kim, S.-K., Kim, T.-H., Kim, M.-C., Park, G. S., Kim, J.-H., Kuninaka, S., Olson, E. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11961 · Cited by 196 · see citing works

Disruption of the c/ebpα Gene in Adult Mouse liver

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Deregulation of Hippo kinase signalling in Human hepatic malignancies

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Stabilization of β-catenin affects mouse embryonic liver growth and hepatoblast fate

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In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease

Stevens, K. R., Scull, M. A., Ramanan, V., Fortin, C. L., Chaturvedi, R. R., Knouse, K. A., Xiao, J., Fung, C., Mirabella, T., Chen, A. X., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5505 · Cited by 165 · see citing works

A single‐cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

Yang, L. C., Wang, W., Qiu, W., Guo, Z., Bi, E., & Xu, C. (2017) · Hepatology · doi:10.1002/hep.29353 · Cited by 162 · see citing works

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes

Ogawa, S., Surapisitchat, J., Virtanen, C., Ogawa, M., Niapour, M., Sugamori, K. S., Wang, S., Tamblyn, L., Guillemette, C., Hoffmann, E., et al. (2013) · Development · doi:10.1242/dev.090266 · Cited by 161 · see citing works

Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling

Akbari, S., Sevinç, G. G., Ersoy, N., Başak, O., Kaplan, K. N., Sevinç, K., Ozel, E., Şengün, B., Enüstün, E., Özçimen, B., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.007 · Cited by 154 · see citing works

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice #

Tchorz, J. S., Kinter, J., Müller, M., Tornillo, L., Heim, M. H., & Bettler, B. (2009) · Hepatology · doi:10.1002/hep.23048 · Cited by 134 · see citing works

Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level

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Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts

Poncy, A., Antoniou, A., Cordi, S., Pierreux, C. E., Jacquemin, P., & Lemaigre, F. P. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.012 · Cited by 125 · see citing works

Echoes of the embryo: using the developmental biology toolkit to study cancer

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β-Catenin is critical for early postnatal liver growth

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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Takeishi, K., Collin de l’Hortet, A., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107711 · Cited by 118 · see citing works

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation†

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Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation

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Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts

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Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

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Promotion of growth factor signaling as a critical function of β-catenin during HCC progression

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Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

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Hippo Signaling in the Liver – A Long and Ever-Expanding Story

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Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool

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Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

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α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals

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Next-Generation Liver Medicine Using Organoid Models

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GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells

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The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

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Eph-ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer

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Liver and Pancreas: Do Similar Embryonic Development and Tissue Organization Lead to Similar Mechanisms of Tumorigenesis?

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Molecular regulation of mammalian hepatic architecture

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Loss of liver function in chronic liver disease: An identity crisis

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Applications of human organoids in the personalized treatment for digestive diseases

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Fetal liver development and implications for liver disease pathogenesis

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Single-cell and spatially resolved transcriptomics for liver biology

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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

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Ginsenoside, a potential natural product against liver diseases: a comprehensive review from molecular mechanisms to application

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Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming

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Human-Induced Pluripotent Stem Cells (iPSCs) for Disease Modeling and Insulin Target Cell Regeneration in the Treatment of Insulin Resistance: A Review

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Comparative Transcriptome Analysis Provides Novel Molecular Events for the Differentiation and Maturation of Hepatocytes during the Liver Development of Zebrafish

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ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation

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Gene expression in the liver of the hagfish (Eptatretus burgeri) belonging to the Cyclostomata is ancestral to that of mammals

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TGF-β and HIPPO Signaling Pathways Interplay in Distinct Hepatic Contexts

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Developmental hepatotoxicity induced by flusilazole in zebrafish: Mechanistic insights into mitochondrial dysfunction, oxidative stress, ferroptosis, and regenerative impairment

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YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

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MicroRNA Profiling of PRELI-Modulated Exosomes and Effects on Hepatic Cancer Stem Cells

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ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint

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Papel de SLU7 en la diferenciación hepática y en la protección del hígado frente al daño: regulación de HNF4A

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Amd1-skp2 cascade regulates hepatocyte proliferation during liver growth and hepatocellular carcinoma development in zebrafishPreprint

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Gradient-Based Regulation of Activin A Directs Multilineage Liver Organoid Development from Human Pluripotent Stem CellsPreprint

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Engineered microtissue systems for identifying the roles of Wnt and YAP signaling in hepatoblast differentiation and organization

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Endodermal Organoids Along Two Axes: Single-Organ Fidelity, Inter-Organ Reconstruction, and the Unbuilt Gut-Lung Frontier

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Generation of Fully Pluripotent Female Murine-Induced Pluripotent Stem Cells1

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Генерування інсулін-продукуючих клітин зі стовбурових клітин. Перепрограмування соматичних клітин

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Generation and Characterization of Induced Pluripotent Stem Cells from Mononuclear Cells in Schizophrenic Patients.

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