Differentiation of progenitors in the liver: a matter of local choice
Open accessAbstract
The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.
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Ductular reactions are activated in chronic liver injury and are thought to contain putative HPCs with the potential to regenerate hepatocytes and cholangiocytes.
“Ductular reactions are activated in chronic liver injury and are thought to contain putative hepatic progenitor cells (HPCs) with the potential to regenerate hepatocytes and cholangiocytes6, 7.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [7]
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- Authors
- Boulter, L., Lu, W.-Y., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Corresponding author
- Forbes, Stuart J.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-05-01
- Volume
- 123
- Issue
- 5
- Pages
- 1867-1873
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3635730
- OpenAlex
- W2095876709
- Cited by
- 116
- References
- 83
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 6 · 2013: 5
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Cancer Research UK
- Medical Research Council (MR/K017047/1)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- liver development, liver progenitor cells, cell fate determination, hepatocyte differentiation, cholangiocyte differentiation, signaling pathways, liver regeneration, liver homeostasis, organogenesis
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Mitosis, Neoplasms, Stem Cells, Signal Transduction, Liver Transplantation, Cell Lineage, Living Donors, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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