Cited by 116Liver physiology and pathologyMesenchymal stem cell researchDevelopmental Biology and Gene Regulation

Differentiation of progenitors in the liver: a matter of local choice

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Boulter, Luke, Lu, Wei-Yu, Forbes, Stuart J.·2013·Journal of Clinical Investigation

Abstract

The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.

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Crossref · 10.1172/jci66026

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  • Ductular reactions are activated in chronic liver injury and are thought to contain putative HPCs with the potential to regenerate hepatocytes and cholangiocytes.

    “Ductular reactions are activated in chronic liver injury and are thought to contain putative hepatic progenitor cells (HPCs) with the potential to regenerate hepatocytes and cholangiocytes6, 7.”

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Authors
Boulter, L., Lu, W.-Y., & Forbes, S. J.
Affiliations
MRC Centre for Regenerative Medicine (GB)
Corresponding author
Forbes, Stuart J.
Venue
Journal of Clinical Investigation
Published
2013-05-01
Volume
123
Issue
5
Pages
1867-1873
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2095876709
Cited by
116
References
83
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 6 · 2013: 5
FWCI
1.56
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Wellcome Trust
  • Cancer Research UK
  • Medical Research Council (MR/K017047/1)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
liver development, liver progenitor cells, cell fate determination, hepatocyte differentiation, cholangiocyte differentiation, signaling pathways, liver regeneration, liver homeostasis, organogenesis
MeSH terms
Animals, Cell Cycle, Cell Differentiation, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Mitosis, Neoplasms, Stem Cells, Signal Transduction, Liver Transplantation, Cell Lineage, Living Donors, Mice, Rats

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