Cited by 43Hippo pathway signaling and YAP/TAZLiver physiology and pathologyCongenital heart defects research

Yes-associated protein is involved in proliferation and differentiation during postnatal liver development

Open access
Septer, Seth, Edwards, Genea, Gunewardena, Sumedha, Wolfe, Andy, Li, Hua, Daniel, James, Apte, Udayan·2012·American Journal of Physiology-Gastrointestinal and Liver Physiology

Abstract

It is known that the liver undergoes size increase and differentiation simultaneously during the postnatal period. Cells in the liver undergo a period of well-controlled proliferation to achieve the adult liver-to-body weight ratio. The postnatal liver growth is also accompanied by simultaneous hepatic differentiation. However, the mechanisms of liver size regulation and differentiation are not completely clear. Herein we report that yes-associated protein (Yap), the downstream effector of the Hippo Kinase signaling pathway, plays a role in liver size regulation and differentiation during the postnatal liver growth period. Postnatal liver growth was studied in C57BL/6 mice over a time course of postnatal days (PND) 0-30. Analysis of nuclear Yap by Western blot indicated peak Yap activation between PND15-20, which coincided with increased cyclin D1 expression and liver cell proliferation. Analysis of postnatal liver development in Yap(+/-) mice revealed a significant decrease in the liver-to-body weight ratio compared with Yap(+/+) mice at PND15 and -30. Yap(+/-) mice exhibited a significant decrease in postnatal liver cell proliferation, but no change in apoptosis was observed. Furthermore, global gene expression analysis of Yap(+/-) livers revealed a role of Yap in regulation of genes involved in bile acid metabolism, retinoic acid metabolism, ion transport, and extracellular matrix proteins. Taken together, these data indicate that Yap plays a role in both cell proliferatio…

Integrity signals

Registry

Crossref · 10.1152/ajpgi.00056.2011

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Septer, S., Edwards, G., Gunewardena, S., Wolfe, A., Li, H., Daniel, J., & Apte, U.
Affiliations
  • Children's Mercy Hospital (US)
  • Department of Pharmacology, Toxicology and Therapeutics and
  • University of Kansas Medical Center (US)
Corresponding author
Apte, Udayan
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Published
2012-03-01
Volume
302
Issue
5
Pages
G493-G503
ISSN
  • 0193-1857 (ISSN-L)
  • 1522-1547
OpenAlex
W2125417595
Cited by
43
References
18
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 2 · 2014: 4
FWCI
0.61
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Kansas
  • National Center for Research Resources (5 P20 RR-021940-03, P20RR021940, RR016475, P20RR016475)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-02528)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
YAP, Hippo signaling pathway, postnatal liver development, liver growth, liver cell proliferation, hepatic differentiation, liver-to-body weight ratio, cyclin D1, bile acid metabolism, retinoic acid metabolism, extracellular matrix
MeSH terms
YAP-Signaling Proteins, Animals, Bile Acids and Salts, Cell Differentiation, Female, Liver, Male, Mice, Inbred C57BL, Organ Size, Phosphoproteins, Tretinoin, Ion Transport, Apoptosis, Cell Cycle Proteins, Gene Expression Profiling, Adaptor Proteins, Signal Transducing, Cell Proliferation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review