The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.
Iron imports. IV. Hepcidin and regulation of body iron metabolism
Abstract
Hepcidin, a small peptide synthesized in the liver, controls extracellular iron by regulating its intestinal absorption, placental transport, recycling by macrophages, and release from stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells. In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia. Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation. Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis.
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“JunD deficiency induced ROS accumulation in the cells (101).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [101]
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Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citationHepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Self-citationPigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
Self-citationLEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214
Hereditary Hemochromatosis — A New Look at an Old Disease
Pietrangelo, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031573 · Cited by 992
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974
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Items 101–103 of 103
Effect of gluten-free diet on the growth and nutritional status of children with coeliac disease
Radlovic, N., Mladenovic, M., Lekovic, Z., Zivanovic, D., Brdar, R., Radlovic, V., Ristic, D., Pavlovic, M., Stojsic, Z., Vuletic, B., et al. (2009) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh0912632r · Cited by 36
Chiabrando, D., Fiorito, V., Marro, S., Silengo, L., Altruda, F., & Tolosano, E. (2013) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2012.08.002 · Cited by 24
Edvinsson, M., Frisk, P., Molin, Y., Hjelm, E., & Ilbäck, N.-G. (2008) · BioMetals · doi:10.1007/s10534-007-9114-7 · Cited by 22
Metadata
- Authors
- Ganz, T., & Nemeth, E.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2006-02
- Volume
- 290
- Issue
- 2
- Pages
- G199-G203
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W1978774658
- Cited by
- 347
- References
- 27
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 22 · 2020: 13 · 2019: 10 · 2018: 10 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 20 · 2013: 18 · 2012: 18
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- hepcidin, iron metabolism, iron imports, ferroportin, intestinal iron absorption, placental iron transport, iron stores, anemia of chronic disease, hypoxia, iron loading, anemia, hemochromatosis, inflammation
- MeSH terms
- Amino Acid Sequence, Anemia, Animals, Hemochromatosis, Humans, Inflammation, Iron, Models, Molecular, Antimicrobial Cationic Peptides, Hepcidins
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