Cited by 347Iron Metabolism and DisordersFerroptosis and cancer prognosisNeurological diseases and metabolism

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Iron imports. IV. Hepcidin and regulation of body iron metabolism

Ganz, Tomas, Nemeth, Elizabeta·2006·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.00412.2005

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Abstract

Hepcidin, a small peptide synthesized in the liver, controls extracellular iron by regulating its intestinal absorption, placental transport, recycling by macrophages, and release from stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells. In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia. Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation. Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis.

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Authors: Ganz, T., & Nemeth, E.
Affiliations: University of California, Los Angeles (US)
ORCID: Ganz, Tomas
Nemeth, Elizabeta
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2006-02
Volume: 290
Issue: 2
Pages: G199-G203
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.00412.2005
OpenAlex: W1978774658
Cited by: 347
References: 27
Citations by year: 2026: 4 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 22 · 2020: 13 · 2019: 10 · 2018: 10 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 20 · 2013: 18 · 2012: 18
FWCI: 21.25
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: hepcidin, iron metabolism, iron imports, ferroportin, intestinal iron absorption, placental iron transport, iron stores, anemia of chronic disease, hypoxia, iron loading, anemia, hemochromatosis, inflammation
MeSH terms: Amino Acid Sequence, Anemia, Animals, Hemochromatosis, Humans, Inflammation, Iron, Models, Molecular, Antimicrobial Cationic Peptides, Hepcidins

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Iron imports. IV. Hepcidin and regulation of body iron metabolism

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