Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925

Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms

Bruewer, M., Luegering, A., Kucharzik, T. F., Parkos, C. A., Madara, J., Hopkins, A. M., & Nusrat, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6164 · Cited by 897

Psychological stress in IBD: new insights into pathogenic and therapeutic implications

Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation

Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472

II. Stress and intestinal barrier function

Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché, Y., & Bonaz, B. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30085 · Cited by 373

Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine

Söderholm, J. D., Yang, P., Ceponis, P., Vohra, A., Riddell, R., Sherman, P. M., & Perdue, M. H. (2002) · Gastroenterology · doi:10.1053/gast.2002.36019 · Cited by 362

Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor

Cao, J., Papadopoulou, N., Kempuraj, D., Boucher, W. S., Sugimoto, K., Cetrulo, C. L., & Theoharides, T. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7665 · Cited by 340

Mast Cell Tryptase Controls Paracellular Permeability of the Intestine

Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506338200 · Cited by 334

Gut–brain axis: How the microbiome influences anxiety and depression

Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615

Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology

Dinan, T. G., & Cryan, J. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.007 · Cited by 577

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

Smith, F., Clark, J. E., Overman, B. L., Tozel, C. C., Huang, J. H., Rivier, J., Blikslager, A. T., & Moeser, A. J. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00081.2009 · Cited by 502

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

The role of neuroimmune signaling in alcoholism

Crews, F. T., Lawrimore, C. J., Walter, T. J., & Coleman, L. G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.031 · Cited by 321

Invited review: The influence of immune activation on transition cow health and performance—A critical evaluation of traditional dogmas

Horst, E. A., Kvidera, S. K., & Baumgard, L. H. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20330 · Cited by 287

CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α

Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039935 · Cited by 207

Crosstalk between the microbiota-gut-brain axis and depression

Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

Leigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 201

From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis

Bermúdez‐Humarán, L. G., Salinas, E., Ortíz, G. G., Ramírez-Jirano, L. J., Morales, J. A., & Bitzer-Quintero, O. K. (2019) · Nutrients · doi:10.3390/nu11040890 · Cited by 184

The gut microbiome and mental health: implications for anxiety- and trauma-related disorders

Malan-Muller, S., Valles-Colomer, M., Raes, J., Lowry, C. A., Seedat, S., & Hemmings, S. M. J. (2018) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2017.0077 · Cited by 161

Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Onyango, A. N. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4321714 · Cited by 168

Brain and gut CRF signaling: biological actions and role in the gastrointestinal tract

Tache, Y., Larauche, M., Yuan, P.-Q., & Million, M. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467210666170224095741 · Cited by 147

Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?

O’Malley, D., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.009 · Cited by 140

Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine

Zheng, P.-Y., Feng, B.-S., Oluwole, C., Struiksma, S., Chen, X., Li, P., Tang, S.-G., & Yang, P.-C. (2009) · Gut · doi:10.1136/gut.2009.181701 · Cited by 129

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

Kiank, C., Zeden, J.-P., Drude, S., Domańska, G., Fusch, G., Otten, W., & Schuett, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011825 · Cited by 127

Corticosterone mediates stress‐related increased intestinal permeability in a region‐specific manner

Zheng, G., Wu, S.-P., Hu, Y., Smith, D. E., Wiley, J. W., & Hong, S. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12066 · Cited by 122

Understanding the Connection between Gut Homeostasis and Psychological Stress

Zhang, H., Wang, Z., Wang, G., Song, X., Qian, Y., Liao, Z., Sui, L., Ai, L., & Xia, Y. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.026 · Cited by 134

Microbiota, immunoregulatory old friends and psychiatric disorders

Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Rodiño‐Janeiro, B. K., Alonso, C., Pigrau, M., Lobo, B., Vicario, M., & Santos, J. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14084 · Cited by 122

Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens

Baxter, M. F. A., Merino-Guzmán, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hernández-Velasco, X., Bielke, L. R., et al. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00056 · Cited by 113

Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice

Medina-Rodriguez, E. M., Madorma, D., O’Connor, G., Mason, B. L., Han, D., Deo, S. K., Oppenheimer, M., Nemeroff, C. B., Trivedi, M. H., Daunert, S., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19090960 · Cited by 110

A role for corticotropin-releasing factor in functional gastrointestinal disorders

Taché, Y., Kiank, C., & Stengel, A. (2009) · Current Gastroenterology Reports · doi:10.1007/s11894-009-0040-4 · Cited by 109

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

Vicario, M., Guilarte, M., Alonso, C., Yang, P., Martínez, C., Ramos, L., Lobo, B., González-Castro, A. M., Guilà, M., Pigrau, M., et al. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.06.002 · Cited by 108

Effect of dexamethasone in feed on intestinal permeability, differential white blood cell counts, and immune organs in broiler chicks

Vicuña, E. A., Kuttappan, V. A., Galarza-Seeber, R., Latorre, J. D., Faulkner, O. B., Hargis, B. M., Tellez, G., & Bielke, L. R. (2015) · Poultry Science · doi:10.3382/ps/pev211 · Cited by 106

Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia

Taché, Y., & Million, M. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14162 · Cited by 102

Cigarette smoking is associated with intestinal barrier dysfunction in the small intestine but not in the large intestine of mice

Zuo, L., Li, Y., Wang, H., Wu, R., Zhu, W., Zhang, W., Cao, L., Gu, L., Gong, J., Li, N., et al. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.08.008 · Cited by 94

Gut microbiota regulates key modulators of social behavior

Parashar, A., & Udayabanu, M. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.002 · Cited by 88

Probiotics Are Effective for the Prevention and Treatment of Citrobacter rodentium–Induced Colitis in Mice

Rodrigues, D. M., Sousa, A. J., Johnson‐Henry, K. C., Sherman, P. M., & Gareau, M. G. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis177 · Cited by 83

The joint power of sex and stress to modulate brain–gut–microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome

Pigrau, M., Rodiño‐Janeiro, B. K., Casado‐Bedmar, M., Lobo, B., Vicario, M., Santos, J., & Alonso, C. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12717 · Cited by 83

Food contact materials and gut health: Implications for toxicity assessment and relevance of high molecular weight migrants

Groh, K. J., Geueke, B., & Muncke, J. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.08.023 · Cited by 68

Neuropeptides, Microbiota, and Behavior

Holzer, P. D. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.005 · Cited by 57

Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.

Buckley, M. M., O’Mahony, S. M., & O’Malley, D. (2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8846 · Cited by 55

Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1

Nozu, T., Miyagishi, S., Nozu, R., Takakusaki, K., & Okumura, T. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0441 · Cited by 57

Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides

Estienne, M., Claustre, J., Clain-Gardechaux, G., Paquet, A., Taché, Y., Fioramonti, J., & Plaisancié, P. (2010) · Gut · doi:10.1136/gut.2009.190728 · Cited by 50

Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?

Torre, D. L., Oudenhove, L. V., Vanuytsel, T., & Verbeke, K. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100579 · Cited by 52

Peripheral α‐helical CRF (9‐41) does not reverse stress‐induced mast cell dependent visceral hypersensitivity in maternally separated rats

van den Wijngaard, R. M., Stanisor, O. I., van Diest, S. A., Welting, O., Wouters, M. M., de Jonge, W. J., & Boeckxstaens, G. E. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01840.x · Cited by 49

Novel insights in the role of peripheral corticotropin‐releasing factor and mast cells in stress‐induced visceral hypersensitivity

Larauche, M. H. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01867.x · Cited by 49

Stress-Derived Corticotropin Releasing Factor Breaches Epithelial Endotoxin Tolerance

Yu, Y., Liu, Z., Liu, X., Yang, L., Geng, X., Yang, G., Liu, Z., Zheng, P., & Yang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065760 · Cited by 49

Evaluating effects of zinc hydroxychloride on biomarkers of inflammation and intestinal integrity during feed restriction

Horst, E. A., Mayorga, E. J., Al‐Qaisi, M., Rodríguez-Jiménez, S., Goetz, B. M., Abeyta, M. A., Gorden, P. J., Kvidera, S. K., & Baumgard, L. H. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18860 · Cited by 48

Inflammatory Bowel Disease Therapies and Gut Function in a Colitis Mouse Model

Nahidi, L., Leach, S. T., Mitchell, H. M., Kaakoush, N. O., Lemberg, D. A., Munday, J. S., Huinao, K. D., & Day, A. S. (2013) · BioMed Research International · doi:10.1155/2013/909613 · Cited by 48

Unique maternal immune and functional microbial profiles during prenatal stress

Antonson, A. M., Evans, M. V., Galley, J. D., Chen, H. J., Rajasekera, T. A., Lammers, S. M., Hale, V. L., Bailey, M. T., & Gur, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-77265-x · Cited by 51

Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors

O’Malley, D., Dinan, T. G., & Cryan, J. F. (2010) · Peptides · doi:10.1016/j.peptides.2010.01.004 · Cited by 47

Antimicrobial anxiety: the impact of stress on antimicrobial immunity

Radek, K. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109740 · Cited by 47

Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat

O’Malley, D., Julio‐Pieper, M., Gibney, S. M., Gosselin, R., Dinan, T. G., & Cryan, J. F. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01412.x · Cited by 45

Stress in the microbiome-immune crosstalk

Beurel, E. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2327409 · Cited by 48

Lactobacillus-Based Probiotics Reduce the Adverse Effects of Stress in Rodents: A Meta-analysis

Mindus, C., Ellis, J. L., van Staaveren, N., & Harlander-Matauschek, A. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.642757 · Cited by 41

Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis

He, H., Zhao, Z., Xiao, C., Li, L., Liu, Y., Fu, J., Liao, H., Zhou, T., & Zhang, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106396 · Cited by 41

Corticotropin-releasing factor family peptide signaling in feline bladder urothelial cells

Hanna‐Mitchell, A. T., Wolf‐Johnston, A., Roppolo, J. R., Buffington, T., & Birder, L. A. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0422 · Cited by 41

Microbiome Big-Data Mining and Applications Using Single-Cell Technologies and Metagenomics Approaches Toward Precision Medicine

Cheng, M., Cao, L., & Ning, K. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00972 · Cited by 42

Using fish models to investigate the links between microbiome and social behaviour: The next step for translational microbiome research?

Soares, M. C., Cable, J., Lima, M. G., Maximino, C., & Xavier, R. (2019) · Fish and Fisheries · doi:10.1111/faf.12366 · Cited by 34

Stress, inflammation, microbiome and depression

Medina-Rodriguez, E. M., Cruz, A. A., Abreu, J. C. D., & Beurel, E. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173561 · Cited by 41

Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway

Zhu, H., Pi, D., Leng, W., Wang, X., Hu, C. A., Hou, Y., Xiong, J., Wang, C., Qin, Q., & Liu, Y. (2017) · Innate Immunity · doi:10.1177/1753425917721631 · Cited by 36

Effect of humic acids on intestinal viscosity, leaky gut and ammonia excretion in a 24 hr feed restriction model to induce intestinal permeability in broiler chickens

Maguey-González, J. A., Michel, M. A., Baxter, M. F. A., Tellez, G., Moore, P. A., Jr., Solís-Cruz, B., Hernández‐Patlan, D., Merino-Guzmán, R., Hernández-Velasco, X., Latorre, J. D., et al. (2018) · Animal Science Journal · doi:10.1111/asj.13011 · Cited by 36

Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability

Ochoa‐Cortés, F., Alba, R. G., Valdez-Moráles, E. E., Spreadbury, I., Barajas‐López, C., Castro, M., Bertrand‐Michel, J., Cénac, N., Vergnolle, N., & Vanner, S. J. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12268 · Cited by 34

Immune Activation in Functional Dyspepsia: Bystander Becoming the Suspect

Ceulemans, M., Jacobs, I., Wauters, L. I., & Vanuytsel, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.831761 · Cited by 32

Comparative analysis of gut microbiota and fecal metabolome features among multiple depressive animal models

Liu, X., Li, X., Teng, T., Jiang, Y., Xiang, Y., Fan, L., Yu, Y., Zhou, X., & Xie, P. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.088 · Cited by 33

Impact of acute water and feed deprivation events on growth performance, intestinal characteristics, and serum stress markers in weaned pigs1

Horn, N. L., Ruch, F. E., Miller, G., Ajuwon, K. M., & Adeola, O. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-7673 · Cited by 31

Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus

He, H., He, H., Mo, L., Yuan, Q., Xiao, C., Ma, Q., Yi, S., Zhou, T., You, Z., & Zhang, J. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100729 · Cited by 30

Comparison of the Activity of Fecal Enzymes and Concentration of SCFA in Healthy and Overweight Children

Śliżewska, K., Włodarczyk, M., Sobczak, M., Barczyńska, R., Kapuśniak, J., Socha, P., Wierzbicka, A., & Kotowska, A. (2023) · Nutrients · doi:10.3390/nu15040987 · Cited by 30

Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge

Zhu, H., Liu, Y., Chen, S., Wang, X., Pi, D., Leng, W., Chen, F., Zhang, J., & Kang, P. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001100 · Cited by 26

Gut feelings: bacteria and the brain.

Foster, J. A. (2013) · Europe PMC (PubMed Central) · Cited by 21

Role of mast cells in mucosal diseases: current concepts and strategies for treatment

Beunk, L., Verwoerd, A., van Overveld, F. J., & Rijkers, G. T. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.82 · Cited by 19

Engineering Human Microbiota: Influencing Cellular and Community Dynamics for Therapeutic Applications

Woloszynek, S., Pastor, S. J., Mell, J. C., Nandi, N., Sokhansanj, B. A., & ROSEN, G. L. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.01.003 · Cited by 20

Involvement of CRF2 signaling in enterocyte differentiation

Ducarouge, B., Pelissier-Rota, M. A., Powell, R., Buisson, A., Bonaz, B. L., & Jacquier‐Sarlin, M. R. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i28.5127 · Cited by 20

Functional gastrointestinal disorders: History taking skills in practice

Daly, M., & Zárate-López, N. (2021) · Clinical Medicine · doi:10.7861/clinmed.2021-0189 · Cited by 18

Corticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy

Zhao, S., Wu, J., He, Z., Song, Y., Chang, X., Xia, T., Xue, F., Li, Z., Xu, C., Wang, S., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00767-8 · Cited by 18

Corticotropin-releasing factor: A possible key to gut dysfunction in the critically ill

Hill, L. T., Kidson, S. H., & Michell, W. L. (2013) · Nutrition · doi:10.1016/j.nut.2012.12.023 · Cited by 19

Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities

Caruso, A., Gaetano, A., & Scaccianoce, S. (2022) · Biology · doi:10.3390/biology11121785 · Cited by 20

Activation of corticotropin-releasing factor receptor 1 aggravates dextran sodium sulphate-induced colitis in mice by promoting M1 macrophage polarization

Chen, H., Shi, H., Liu, Y., Ren, X., He, S., Chang, X.-M., & Yin, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7909 · Cited by 17

Genistein improves depression-like behavior in rats by regulating intestinal flora and altering glutamate gene expression

Ma, C., Zhang, F., Zhao, X., Yang, Y., Wang, B., Wang, Y., Liu, X.-F., Bian, X., Xu, Z., Zhang, G., et al. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.101020 · Cited by 16

Mast cell activation is involved in stress‐induced epithelial barrier dysfunction in the esophagus

Zhong, C. J., Wang, K., Zhang, L., Yang, C. Q., Zhang, K., Shu, Z., & Duan, L. (2015) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12226 · Cited by 14

Interactions between the gut microbiome and the central nervous system and their role in schizophrenia, bipolar disorder and depression

Chrobak, A. A., Nowakowski, J., & Dudek, D. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/62962 · Cited by 15

Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation

Hu, Y., Bin, L., Chaoying, C., Meng, Z., Meng, L. Y., & Wang, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485420 · Cited by 14

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Zhang, T., Zhang, B., Ma, X., Zhang, J., Wei, Y., Wang, F., & Tang, X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1109510 · Cited by 15

Plasma metabolomic profiling of repeated restraint stress in rats

Chen, D., Lu, D.-C., Wang, W., Chen, W., Zhang, S., & Wei, S. (2020) · Journal of Chromatography B · doi:10.1016/j.jchromb.2020.122294 · Cited by 13

Early Life Stress Induces Both Acute and Chronic Colonic Barrier Dysfunction

Gareau, M. G., Wine, E., & Sherman, P. M. (2009) · NeoReviews · doi:10.1542/neo.10-4-e191 · Cited by 13

The hygiene hypothesis and affective and anxiety disorders

Rook, G. A. W., & Lowry, C. A. (2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8903-1_11 · Cited by 13

Maternal Exposure to Low Levels of Corticosterone during Lactation Protects against Experimental Inflammatory Colitis-Induced Damage in Adult Rat Offspring

Petrella, C., Giuli, C., Agostini, S., Bacquie, V., Zinni, M., Théodorou, V., Broccardo, M., Casolini, P., & Improta, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113389 · Cited by 13

Corticotropin releasing hormone activates CD 14+ cells to induce endothelial barrier dysfunction

Song, J., Chen, X., Yang, G., & Geng, X. (2013) · Cell Biology International · doi:10.1002/cbin.10133 · Cited by 12

Impairment of CRH in the intestinal mucosal epithelial barrier of pregnant Bama miniature pig induced by restraint stress

Xu, W., Lu, J., Chen, Y., Wang, Z., Cao, J., & Dong, Y. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej20-0332 · Cited by 11

De la colopathie fonctionnelle à la neurogastroentérologie

Ducrotte, P. R. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2009.07.006 · Cited by 11

Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs

Pagán-Busigó, J. E., López-Carrasquillo, J., Appleyard, C. B., & Torres-Reverón, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264909 · Cited by 10

Alcohol-Dependence and the Microbiota-Gut-Brain Axis

Stärkel, P., Leclercq, S., Delzenne, N. M., & de Timary, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00017-7 · Cited by 9

Gut microbiota in anxiety and depression: mechanisms, drug interactions, and therapeutic implications

Fatimi, H. E., El‐Mansoury, B., Tinakoua, A., Ndayambaje, M., Zaid, Y., Khalki, H., & Khalki, L. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00759-w · Cited by 10

Effects of Bifidobacterium bifidum in Mice Infected with Citrobacter rodentium

Wen, B., Taïbi, A., Villa, C., Lee, S. H., Sagaidak, S., & Comelli, E. M. (2019) · Microorganisms · doi:10.3390/microorganisms7020051 · Cited by 9

Effects of stress‐related peptides on chloride secretion in the mouse proximal colon

Liu, S., Karo, A., Agterberg, S., Hua, H., & Bhargava, A. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14021 · Cited by 9

Effects of Stress on Intestinal Mucosal Functions

Söderholm, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00074-9 · Cited by 10

Role of Corticotrophin-releasing Factor in the Stress-induced Dilation of Esophageal Intercellular Spaces

Cho, Y. J., Kim, J., Yim, H. E., Lee, D. M., Im, S. K., & Lee, K. J. (2011) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.2.279 · Cited by 8

Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors

Medina-Rodriguez, E. M., Han, D., Zeltzer, S. E., Moraskie, M., O’Connor, G., Daunert, S., & Beurel, E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.016 · Cited by 7

Role of nociceptin/orphanin FQ receptors in the decrease of mucosal mast cells caused by acute stress in the rat colon

Grandi, D., Massi, M., Guerrini, R., Calò, G., & Morini, G. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.08.015 · Cited by 7

Mode of Action of Dietary Dexamethasone May Not Be Dependent Upon Microbial Mechanisms in Broilers

Duff, A. F., Baxter, M. F. A., Graham, D. B., Hargis, B. M., & Bielke, L. R. (2019) · Microorganisms · doi:10.3390/microorganisms7090346 · Cited by 5

Impact of Human Microbiome on Health

Das, S., Khanna, C., Singh, S., Nandi, S., & Verma, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-4099-8_20 · Cited by 6

Bacteria and the brain

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Neurobiology of Corticotropin-Releasing Factor in the Enteric Nervous System during Stress

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Effects of stress on the human body

Пизова, Н. В., Pizov, A. V., & Solovyov, I. N. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-273 · Cited by 2

Mast cells and corticotropin‐releasing hormone receptors in duodenal tissue of children with functional dyspepsia

Pearlstein, H., Chao, T., He, Z., & Molle‐Rios, Z. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12477 · Cited by 2

On mechanisms of increased intestinal wall permeability under stress

Олегович, В. А., Бобынцев, И. И., & Медведева, О. А. (2022) · Человек и его здоровье · doi:10.21626/vestnik/2022-2/05 · Cited by 3

Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis

Zheng, J.-C., Jin, Z.-R., Liu, B.-H., Tian, Y., Li, J.-X., Cai, J., Jiang, H., & Xing, G. (2026) · Nature Communications · doi:10.1038/s41467-026-72450-4 · Cited by 1

Mast Cell Corticotropin Releasing Factor Receptor Subtypes Play Opposing Roles in Mediating Stress‐Induced Colonic Barrier Dysfunction

Moeser, A. J., & Gibson, A. J. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1107.1

CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α

Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039935 · Cited by 207

Role of peripheral CRF signalling pathways in stress‐related alterations of gut motility and mucosal function

Taché, Y., & Perdue, M. H. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00490.x · Cited by 289

Intestinal CRF Receptor Subtypes Mediate Distinct Intestinal Barrier Function Responses Through Intestinal Mast Cell Activation

Overman, E. L., Rivier, J., & Moeser, A. J. (2011) · Gastroenterology · doi:10.1016/s0016-5085(11)62687-5

Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro

Wallon, C., Yang, P.-C., Keita, Å. V., Ericson, A.-C., McKay, D. M., Sherman, P. M., Perdue, M. H., & Söderholm, J. D. (2007) · Gut · doi:10.1136/gut.2006.117549 · Cited by 267