Crosstalk between the microbiota-gut-brain axis and depression

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works

Gut microbiota in health and disease

Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

Gut–brain axis: How the microbiome influences anxiety and depression

Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 2× · see citing works

Altered fecal microbiota composition in patients with major depressive disorder

Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works

Interactions between the microbiota, immune and nervous systems in health and disease

Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works

Depression Is the Leading Cause of Disability Around the World

Friedrich, M. J. (2017) · JAMA · doi:10.1001/jama.2017.3826 · Cited by 1,459 · see citing works

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science · doi:10.1126/science.aaf9794 · Cited by 1,382 · see citing works

Cytokine-Associated Emotional and Cognitive Disturbances in Humans

Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works

Assessment of psychotropic-like properties of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in rats and human subjects

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works

Decreased serum brain-derived neurotrophic factor levels in major depressed patients

Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156 · see citing works

The spectrum of behaviors influenced by serotonin

Lucki, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00139-5 · Cited by 1,154 · see citing works

Diet dominates host genotype in shaping the murine gut microbiota

Carmody, R. N., Gerber, G. K., Luevano, J. M., Gatti, D. M., Somes, L., Svenson, K. L., & Turnbaugh, P. J. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.11.010 · Cited by 1,103 · see citing works

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works

Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses

O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works

Correlation between the human fecal microbiota and depression

Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works

Evidence for an immune response in major depression: A review and hypothesis

Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003 · see citing works

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works

The stress system in the human brain in depression and neurodegeneration

Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works

The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat

Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works

Cytokine, Sickness Behavior, and Depression

Dantzer, R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.002 · Cited by 789 · see citing works

Inter-kingdom signalling: Communication between bacteria and their hosts

Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761 · see citing works

Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour

Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works

Mast cells and inflammation

Theoharides, T. C., Alysandratos, K., Angelidou, A., Delivanis, D.-A., Sismanopoulos, N., Zhang, B., Asadi, S., Vasiadi, M., Weng, Z., Miniati, A., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.014 · Cited by 759 · see citing works

Dopamine system dysregulation in major depressive disorders

Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732 · see citing works

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works

Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [ ¹¹ C]Raclopride

Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709 · see citing works

Bacterial translocation (BT) in cirrhosis†

Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677 · see citing works

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651 · see citing works

Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K. V., O’Connor, G., Grati, M., Mittal, J., Yan, D. L. S., Eshraghi, A. A., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25518 · Cited by 644 · see citing works

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., Kheradman, R., Heuman, D. M., Wang, J., Gurry, T., et al. (2017) · Hepatology · doi:10.1002/hep.29306 · Cited by 637 · see citing works

Our gut microbiome: The evolving inner self

Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017) · Cell · doi:10.1016/j.cell.2017.11.024 · Cited by 633 · see citing works

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612 · see citing works

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3566-09.2009 · Cited by 597 · see citing works

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592 · see citing works

Assessing anhedonia in depression: potentials and pitfalls

Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works

Intestinal Microbiota of 6‐week‐old Infants Across Europe: Geographic Influence Beyond Delivery Mode, Breast‐feeding, and Antibiotics

Fallani, M., Young, D., Scott, J. A., Norin, E. L., Amarri, S., Adam, R., Aguilera, J., Khanna, S., Gil, Á., Edwards, C. A., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d1b11e · Cited by 559 · see citing works

Linkage of gut microbiome with cognition in hepatic encephalopathy

Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547 · see citing works

Signaling pathways underlying the rapid antidepressant actions of ketamine

Duman, R. S., Li, N., Liu, R.-J., Duric, V., & Aghajanian, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.044 · Cited by 537 · see citing works

The microbiome: a key regulator of stress and neuroinflammation

Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works

Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works

Depression, stress and immunological activation: The role of cytokines in depressive disorders

Connor, T. J., & Leonard, B. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)00990-9 · Cited by 478 · see citing works

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation

Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472 · see citing works

Probiotic gut effect prevents the chronic psychological stress‐induced brain activity abnormality in mice

Ait‐Belgnaoui, A., Colom, A., Braniste, V., Ramalho, L., Marrot, A., Cartier, C., Houdeau, E., Theodorou, V., & Tompkins, T. (2014) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12295 · Cited by 434 · see citing works

Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry

Sharma, S., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.48 · Cited by 424 · see citing works

Melancholic microbes: a link between gut microbiota and depression

Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12198 · Cited by 424 · see citing works

Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression

Cryan, J. F., & Kaupmann, K. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.11.004 · Cited by 421 · see citing works

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression

Barden, N. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0421 · Cited by 416 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works

The gut microbiome and diet in psychiatry: focus on depression

Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000117 · Cited by 369 · see citing works

Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics

Yu, M., Jia, H., Zhou, C., Yang, Y., Zhao, Y., Yang, M., & Zou, Z. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.02.008 · Cited by 366 · see citing works

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355 · see citing works

The gut-brain axis: the missing link in depression

Evrensel, A., & Ceylan, M. E. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.3.239 · Cited by 338 · see citing works

Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression

Luna, R. A., & Foster, J. A. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.007 · Cited by 325 · see citing works

Association of high-sensitivity C-reactive protein with <i>de novo</i> major depression

Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076430 · Cited by 321 · see citing works

Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

Santos, J., Yang, P.-C., Söderholm, J. D., Benjamin, M., & Perdue, M. H. (2001) · Gut · doi:10.1136/gut.48.5.630 · Cited by 313 · see citing works

Modulation of Gut Microbiota–Brain Axis by Probiotics, Prebiotics, and Diet

Liu, X., Cao, S., & Zhang, X. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02404 · Cited by 304 · see citing works

Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse

Bangsgaard Bendtsen, K. M., Krych, L., Sørensen, D. B., Pang, W., Nielsen, D. S., Josefsen, K., Hansen, L. H., Sørensen, S. J., & Hansen, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046231 · Cited by 299 · see citing works

Altered colonic function and microbiota profile in a mouse model of chronic depression

Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

Gerhard, D. M., Wohleb, E. S., & Duman, R. S. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.016 · Cited by 287 · see citing works

Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Janik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.018 · Cited by 283 · see citing works

Lower dopamine transporter binding potential in striatum during depression

Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269 · see citing works

Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood

Robertson, R. C., Seira Oriach, C., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., Paul Ross, R., & Stanton, C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.145 · Cited by 268 · see citing works

Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis

Tian, P., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.007 · Cited by 257 · see citing works

Effects of obesity on depression: A role for inflammation and the gut microbiota

Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 252 · see citing works

Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances

Wang, S.-S., Kamphuis, W., Huitinga, I., Zhou, J.-N., & Swaab, D. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.38 · Cited by 250 · see citing works

Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat

Davey, K. J., Cotter, P. D., O'Sullivan, O., Crispie, F., Dinan, T. G., Cryan, J. F., & O'Mahony, S. M. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.83 · Cited by 236 · see citing works

Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress

Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236 · see citing works

NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model

Su, W., Zhang, Y., Chen, Y., Gong, H., Lian, Y., Wei, P., Liu, Y., Wang, Y., You, Z., Feng, S.-J., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.018 · Cited by 214 · see citing works

Combination of <i>Lactobacillus helveticus R0052</i> and <i>Bifidobacterium longum R0175</i> reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model

Arseneault-Bréard, J., Rondeau, I., Gilbert, K., Girard, S.-A., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511005137 · Cited by 205 · see citing works

In Vivo Effects of Bifidobacteria and Lactoferrin on Gut Endotoxin Concentration and Mucosal Immunity in Balb/c Mice

Griffiths, E. A., Duffy, L. C., Schanbacher, F. L., Qiao, H., Dryja, D., Leavens, A., Rossman, J., Rich, G. A., DiRienzo, D. B., & Ogra, P. L. O. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000026302.92898.ae · Cited by 197 · see citing works

Probiotic treatment reduces depressive-like behaviour in rats independently of diet

Abildgaard, A., Elfving, B., Hokland, M., Wegener, G., & Lund, S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.014 · Cited by 196 · cited 1× · see citing works

Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action

Shafiee, M., Arekhi, S., Omranzadeh, A., & Sahebkar, A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.020 · Cited by 185 · see citing works

A Closer Look at Bacteroides: Phylogenetic Relationship and Genomic Implications of a Life in the Human Gut

Karlsson, F. H., Ussery, D. W., Nielsen, J., & Nookaew, I. (2011) · Microbial Ecology · doi:10.1007/s00248-010-9796-1 · Cited by 179 · see citing works

Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice

Moya-Pérez, Á., Pérez‐Villalba, A., Benítez‐Páez, A., Campillo, I., & Sanz, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.011 · Cited by 177 · see citing works

Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain

Yang, C., Fang, X., Zhan, G., Huang, N., Li, S., Bi, J., Jiang, R., Yang, L., Miao, L., Zhu, B., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0379-8 · Cited by 176 · see citing works

Colocalization of corticotropin-releasing hormone and oestrogen receptor-α in the paraventricular nucleus of the hypothalamus in mood disorders

Bao, A., Hestiantoro, A., Someren, E. J. W. V., Swaab, D. F., & Zhou, J. (2005) · Brain · doi:10.1093/brain/awh448 · Cited by 172 · see citing works

Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression

Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172 · see citing works

High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome

Hassan, A. M., Mancano, G., Kashofer, K., Fröhlich, E. E., Matak, A., Mayerhofer, R., Reichmann, F., Olivares, M., Neyrinck, A. M., Delzenne, N. M., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1465713 · Cited by 166 · see citing works

Tryptophan depletion decreases the recognition of fear in female volunteers

Harmer, C. J., Rogers, R. D., Tunbridge, E. M., Cowen, P. J., & Goodwin, G. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1401-6 · Cited by 162 · see citing works

A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice

Jørgensen, B. P., Hansen, J. T., Krych, Ł., Larsen, C. S., Klein, A. B., Nielsen, D. S., Josefsen, K. E., Hansen, A. K., & Sørensen, D. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103398 · Cited by 150 · see citing works

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

Teitelbaum, A. A., Gareau, M. G., Jury, J., Yang, P. C., & Perdue, M. H. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90210.2008 · Cited by 116 · see citing works

Medical research: If depression were cancer

Ledford, H. K. (2014) · Nature · doi:10.1038/515182a · Cited by 111 · see citing works

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

Winther, G., Jørgensen, B. M., Elfving, B., Nielsen, D. S., Kihl, P., Lund, S. A., Sørensen, D. B., & Wegener, G. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.7 · Cited by 105 · see citing works

Mice lacking the dopamine transporter display altered regulation of distal colonic motility

Walker, J. K. L., Gainetdinov, R. R., Mangel, A. W., Caron, M. G., & Shetzline, M. A. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.2.g311 · Cited by 96 · see citing works

THE ROLE OF MICROBIOTA IN DEPRESSION - A BRIEF REVIEW

Zalar, B., Haslberger, A., & Peterlin, B. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.136 · Cited by 94 · see citing works

Risk factors of development of gut-derived bacterial translocation in thermally injured rats

Zhong-tang, W. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i11.1619 · Cited by 90 · see citing works

Dopamine production in Enterococcus faecium: A microbial endocrinology-based mechanism for the selection of probiotics based on neurochemical-producing potential

Villageliú, D. N., & Lyte, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207038 · Cited by 89 · see citing works

Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and alter gene expression within neural circuits important for stress resistance

Mika, A., Day, H. E. W., Martinez, A. S., Rumian, N. L., Greenwood, B. N., Chichlowski, M., Berg, B. M., & Fleshner, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13444 · Cited by 88 · see citing works

Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis

Farzi, A., Hassan, A. M., Zenz, G., & Holzer, P. D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.11.003 · Cited by 77 · see citing works

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

van der Kleij, H. P. M., O’Mahony, C., Shanahan, F., O’Mahony, L., & Bienenstock, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90434.2008 · Cited by 70 · see citing works

Attenuation of post-myocardial infarction depression in rats byn-3 fatty acids or probiotics starting after the onset of reperfusion

Kim, G., Arseneault-Bréard, J., Monaco, F. F., Beaudoin, A., Bah, T. M., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003807 · Cited by 64 · see citing works

THE ROLE OF MICROBIOTA IN DEPRESSION - A BRIEF REVIEW

Zalar, B., Haslberger, A. G., & Peterlin, B. (2018) · Psychiatria Danubina · doi:10.24869/spsih.2018.136 · Cited by 62 · see citing works

Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Bhattarai, Y. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13366 · Cited by 59 · see citing works

BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats

Han, Y.-X., Chen, T., Gao, X., Wang, L., Jiang, F.-H., Wang, C., Fang, K., Chen, X.-X., Chen, Z., & Ge, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00731 · Cited by 58 · see citing works

Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37.

Mastrangelo, F., Frydas, I., Ronconi, G., Kritas, S. K., Tettamanti, L., Caraffa, A., Ovidio, C. D., Younes, A., Gallenga, C. E., & Conti, P. (2018) · PubMed · Cited by 49 · see citing works

Effects of a high-fat diet and bamboo extract supplement on anxiety- and depression-like neurobehaviours in mice

Rosario, A. D., McDermott, M. M., & Panee, J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511006738 · Cited by 48 · see citing works

Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation

Ruan, X., Shi, H., Xia, G., Xiao, Y., Dong, J., Ming, F.-P., & Wang, S. (2007) · Nutrition · doi:10.1016/j.nut.2007.07.002 · Cited by 42 · see citing works

Gut microbiota and the liver

Federico, A., Dallio, M., Caprio, G. G., Ormando, V. M., & Loguercio, C. (2017) · Minerva Gastroenterology · doi:10.23736/s1121-421x.17.02375-3 · Cited by 37 · see citing works

Anti-inflammatory treatment and risk for depression

Wium‐Andersen, I. K., Wium‐Andersen, M. K., Jørgensen, M. B., & Osler, M. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn160244 · Cited by 36 · see citing works

Investigational drugs for treating major depressive disorder

Dhir, A. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1267727 · Cited by 31 · see citing works

Clinical science workshop: targeting the gut-liver-brain axis

Patel, V., White, H., Støy, S. H., Bajaj, J. S., & Shawcross, D. L. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9743-4 · Cited by 27 · see citing works

Gut Microbiota and the Liver

Koch, M. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000699 · Cited by 23 · see citing works

Herbal Formula Fo Shou San Attenuates Alzheimer’s Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer’s Disease

Lu, J., Guo, P., Liu, X., Zhang, Y., Guo, X., Gao, X. Y., & Chen, Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/8302950 · Cited by 23 · see citing works

Effects of different degrees of depression on inflammatory response and immune function in patients with ovarian cancer.

Su, J., Liu, H. F., Zhang, H. L., He, Y. J., & Nie, Y. (2018) · PubMed · Cited by 14 · see citing works

Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines.

Franza, L., Carusi, V., Altamura, S., Gasbarrini, A., Caraffa, A., Kritas, S. K., Ronconi, G., Gallenga, C. E., Virgilio, F. D., & Pandolfi, F. (2019) · PubMed · Cited by 7 · see citing works

[Current progress in neuroimaging research on treatment resistant depression].

Peng, W. J., Jia, Z., & Gong, Q. (2018) · PubMed Central · doi:10.7507/1001-5515.201705086 · Cited by 4 · see citing works

Untitled work

Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets

Kouba, B. R., Borba, L. A., de Souza, P. B., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2024) · Cells · doi:10.3390/cells13050423 · Cited by 232 · see citing works

The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies

Alli, S. R., Gorbovskaya, I., Liu, J. C. W., Kolla, N. J., Brown, L., & Müller, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094494 · Cited by 202 · see citing works

Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products

Toro-Barbosa, M. D., Hurtado‐Romero, A., García-Amezquita, L. E., & García‐Cayuela, T. (2020) · Nutrients · doi:10.3390/nu12123896 · Cited by 195 · see citing works

Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options

Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 164 · see citing works

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 177 · see citing works

Health Benefits of Consuming Foods with Bacterial Probiotics, Postbiotics, and Their Metabolites: A Review

Vera-Santander, V. E., Hernández‐Figueroa, R. H., Jiménez‐Munguía, M. T., Mani‐López, E., & López‐Malo, A. (2023) · Molecules · doi:10.3390/molecules28031230 · Cited by 149 · see citing works

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Guijarro, L. G., Lahera, G., Monserrat, J., Valls, P., Mora, F., Rodríguez–Jiménez, R., et al. (2022) · Metabolites · doi:10.3390/metabo12010050 · Cited by 125 · see citing works

Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

Johnson, D., Thurairajasingam, S., Letchumanan, V., Chan, K., & Lee, L. (2021) · Nutrients · doi:10.3390/nu13051728 · Cited by 112 · see citing works

Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines

Wang, F., Zhang, Q., Cui, J., Bao, B., Deng, X., Liu, L., & Guo, M. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121233 · Cited by 105 · see citing works

The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights

Marano, G., Mazza, M., Lisci, F. M., Ciliberto, M., Traversi, G., Kotzalidis, G. D., Berardis, D. D., Laterza, L., Sani, G., Gasbarrini, A., et al. (2023) · Nutrients · doi:10.3390/nu15061496 · Cited by 109 · see citing works

Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review

dos Santos, É. R. Q., Maia, J. G. S., Fontes-Júnior, E. A., & Maia, C. D. S. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210920094504 · Cited by 107 · see citing works

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

Knudsen, J. K., Bundgaard‐Nielsen, C., Hjerrild, S., Nielsen, R. E., Leutscher, P., & Sørensen, S. (2021) · Brain and Behavior · doi:10.1002/brb3.2177 · Cited by 93 · see citing works

Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics

Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 101 · see citing works

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics

Fang, S., Wu, Z., Guo, Y., Zhu, W., Wan, C., Yuan, N., Chen, J., Hao, W., Mo, X., Guo, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1193053 · Cited by 101 · see citing works

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

Toader, C., Dobrin, N., Costea, D., Glavan, L.-A., Covache-Busuioc, R.-A., Dumitrascu, D.-I., Bratu, B.-G., Costin, H. P., & Ciurea, A. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063340 · Cited by 90 · see citing works

Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota

Fan, L., Peng, Y., Wang, J., Ma, P., Zhao, L., & Li, X. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153471 · Cited by 82 · see citing works

Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions

Holmes, A., Finger, C. E., Morales‐Scheihing, D., Lee, J., & McCullough, L. D. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.012 · Cited by 87 · see citing works

Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues

Bhatt, S., Kanoujia, J., Lakshmi, S. M., Patil, C., Gupta, G., Chellappan, D. K., & Dua, K. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220329140804 · Cited by 81 · see citing works

Bacterial acetate metabolism and its influence on human epithelia.

Hosmer, J., McEwan, A. G., & Kappler, U. (2024) · PubMed Central · doi:10.1042/etls20220092 · Cited by 70 · see citing works

Physical activity before and during pregnancy and maternal mental health: A systematic review and meta-analysis of observational studies

Cai, C., Busch, S., Wang, R., Sivak, A., & Davenport, M. H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.143 · Cited by 65 · see citing works

The outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates the depression-like behavior of depressed mice induced by chronic stress

Cheng, R., Xu, W., Wang, J., Tang, Z., & Zhang, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.018 · Cited by 63 · see citing works

Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule

Onaolapo, A. Y., & Onaolapo, O. J. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i7.297 · Cited by 66 · see citing works

Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder

Kovtun, A. S., Averina, O. V., Angelova, I. Y., Yunes, R. А., Zorkina, Y., Morozova, A. Y., Pavlichenko, A. V., Syunyakov, T., Karpenko, O., Kostyuk, G. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092162 · Cited by 67 · see citing works

Pathogenesis and treatment of depression: Role of diet in prevention and therapy

Mrozek, W., Socha, J., Sidorowicz, K., Skrok, A., Syrytczyk, A., Piątkowska‐Chmiel, I., & Herbet, M. (2023) · Nutrition · doi:10.1016/j.nut.2023.112143 · Cited by 64 · see citing works

Association between gut microbiota and psychiatric disorders: a systematic review

Valle, C. G.-D., Fernández, J., Solá, E., Montoya‐Castilla, I., Morillas, C., & Bañuls, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1215674 · Cited by 61 · see citing works

Gut microbiota resilience in horse athletes following holidays out to pasture

Mach, N., Lansade, L., Bars‐Cortina, D., Dhorne‐Pollet, S., Foury, A., Moisan, M., & Ruet, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84497-y · Cited by 55 · see citing works

Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota

Chung, J. Y., Jeong, J., & Song, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.588044 · Cited by 55 · see citing works

Understanding the Biological Relationship between Migraine and Depression

Viudez‐Martínez, A., Torregrosa, A. B., Navarrete, F., & García‐Gutiérrez, M. S. (2024) · Biomolecules · doi:10.3390/biom14020163 · Cited by 55 · see citing works

Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis

Liu, H., Guo, X., Jiang, K., Shi, B., Liu, L., Hou, R., Chen, G., Farag, M. A., Yan, N., & Liu, L. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138739 · Cited by 52 · see citing works

Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice

Huang, F., Liu, X., Xu, S., Hu, S., Wang, S., Shi, D., Wang, K., Wang, Z., Lin, Q., Li, S., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.805465 · Cited by 50 · see citing works

Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection

Fakhri, S., Yarmohammadi, A., Yarmohammadi, M., Farzaei, M. H., & Echeverría, J. (2021) · Marine Drugs · doi:10.3390/md19030165 · Cited by 51 · see citing works

Advances in the mechanisms of polysaccharides in alleviating depression and its complications

Guo, Y., Chen, X., Gong, P., Li, Z., Wu, Y., Zhang, J., Wang, J., Yao, W., Yang, W., & Chen, F. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154566 · Cited by 53 · see citing works

Probiotics, Live Biotherapeutic Products (LBPs), and Gut-Brain Axis Related Psychological Conditions: Implications for Research and Dietetics

Ağagündüz, D., Çelik, E., Cemali, Ö., Bingöl, F. G., Özenir, Ç., Özoğul, F., & Capasso, R. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10092-4 · Cited by 47 · see citing works

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Danilenko, V., Devyatkin, A., Marsova, M., Shibilova, M., Ilyasov, R. A., & Shmyrev, V. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s333887 · Cited by 53 · see citing works

Effects of thermal exposure to disposable plastic tableware on human gut microbiota and metabolites: A quasi-experimental study

Zhang, X., He, X., Pan, D., Shi, L., Wu, Y., Yang, Y., Zhu, Y., Wang, H., Wang, H., Pu, L., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132800 · Cited by 43 · see citing works

The modified outer membrane protein Amuc_1100 of Akkermansia muciniphila improves chronic stress-induced anxiety and depression-like behavior in mice

Cheng, R., Zhu, H., Yan, S., Hang, T., & Zhang, M. (2022) · Food & Function · doi:10.1039/d2fo01198k · Cited by 40 · see citing works

Gut microbiome-gut brain axis-depression: interconnection

Patel, R. A., Panche, A. N., & Harke, S. N. (2024) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2024.2436854 · Cited by 43 · see citing works

Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis

Mao, Q., Zhang, H., Zhang, Z., Lu, Y., Pan, J., Guo, D., Huang, L., Tian, H., & Ma, K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155510 · Cited by 38 · see citing works

Mechanism and therapeutic strategies of depression after myocardial infarction

Yang, Y., Li, X., Chen, S., Xiao, M., Liu, Z., Li, J., & Cheng, Y. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05784-0 · Cited by 38 · see citing works

The Complex Molecular Picture of Gut and Oral Microbiota–Brain-Depression System: What We Know and What We Need to Know

Scassellati, C., Marizzoni, M., Cattane, N., Lopizzo, N., Mombelli, E., Riva, M. A., & Cattaneo, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.722335 · Cited by 40 · see citing works

Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment

Xu, J., Tang, M., Wu, X., Kong, X., Liu, Y., & Xu, X. (2022) · Food & Function · doi:10.1039/d1fo03804d · Cited by 38 · see citing works

The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression

Liu, Y., Wu, Z., Cheng, L., Zhang, X., & Yang, H. (2021) · Food & Function · doi:10.1039/d1fo01091c · Cited by 37 · see citing works

The critical role of gut-brain axis microbiome in mental disorders

Basiji, K., Sendani, A. A., Ghavami, S. B., Farmani, M., Kazemifard, N., Sadeghi, A., Lotfali, E., & Aghdaei, H. A. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01248-w · Cited by 36 · see citing works

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

Álvarez-Mon, M. Á., Ortega, M. A., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Lahera, G., Mora, F., Rodríguez-Quiroga, A., Fernández-Rojo, S., Quintero, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080821 · Cited by 36 · see citing works

Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours

Feng, S., Chen, M., Liu, Y., Yi, Y., Liang, A., Zhang, Y., & Hao, Z. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12580-7 · Cited by 34 · see citing works

Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

Sah, R. K., Nandan, A., Athira, K. V., Prashant, S. K., Sankaran, S., Jose, A., Venkidasamy, B., & Nile, S. H. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103861 · Cited by 35 · see citing works

Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview

Tao, K., Yuan, Y., Xie, Q., & Dong, Z. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115111 · Cited by 34 · see citing works

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

Chen, J., Liu, K.-K., Sun, X., Shi, X., Guanghui, Z., & Yang, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.992065 · Cited by 32 · see citing works

Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease

Soni, D., Upadhayay, S., Dhureja, M., Arthur, R., & Kumar, P. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01510-2 · Cited by 31 · see citing works

Gut microbiota: A new target for traditional Chinese medicine in the treatment of depression

Li, B., Xu, M., Wang, Y. H. D., Feng, L., Xing, H., & Zhang, K. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116038 · Cited by 30 · see citing works

Isha yoga practices, vegan diet, and participation in Samyama meditation retreat: impact on the gut microbiome & metabolome – a non-randomized trial

Raman, M., Vishnubhotla, R. V., Ramay, H. R., Gonçalves, M. C. B., Shin, A., Pawale, D., Subramaniam, B., & Sadhasivam, S. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03935-8 · Cited by 32 · see citing works

Psychobiotics for Mitigation of Neuro‐Degenerative Diseases: Recent Advancements

Dhyani, P., Goyal, C., Dhull, S. B., Chauhan, A. K., Saharan, B. S., Harshita, Duhan, J. S., & Gökşen, G. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300461 · Cited by 30 · see citing works

The Role of Gut Microbiota in Neuropsychiatric Diseases – Creation of An Atlas-Based on Quantified Evidence

Bonnechère, B., Amin, N., & van Duijn, C. M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.831666 · Cited by 31 · see citing works

Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center

Scaldaferri, F., D’Onofrio, A. M., Calia, R., Vincenzo, F. D., Ferrajoli, G. F., Petito, V., Maggio, E., Pafundi, P. C., Napolitano, D., Masi, L., et al. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad091 · Cited by 30 · see citing works

The Role of Psychobiotics to Ensure Mental Health during the COVID-19 Pandemic—A Current State of Knowledge

Zielińska, D., Karbowiak, M., & Brzezicka, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191711022 · Cited by 28 · see citing works

Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders

Daliry, A., & Pereira, E. N. G. D. S. (2021) · Nutrients · doi:10.3390/nu13103533 · Cited by 28 · see citing works

Glyphosate: Impact on the microbiota-gut-brain axis and the immune-nervous system, and clinical cases of multiorgan toxicity

Mazuryk, J., Klepacka, K., Kutner, W., & Sharma, P. S. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.115965 · Cited by 26 · see citing works

Electroacupuncture regulates gut microbiota to reduce depressive-like behavior in rats

Wang, J., Zhu, H., Song, X., Zhao, J., Zhang, J., Zhang, J., Li, S., & Rong, P. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1327630 · Cited by 26 · see citing works

Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms

Voigt, R. M., Zalta, A. K., Raeisi, S., Zhang, L., Brown, J. M., Forsyth, C. B., Boley, R. A., Held, P., Pollack, M. H., & Keshavarzian, A. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2022 · Cited by 26 · see citing works

Combined effects of lead and manganese on locomotor activity and microbiota in zebrafish

Xia, Y., Wang, C., Zhang, X., Li, J., Li, Z., Zhu, J., Zhou, Q., Yang, J. T., Chen, Q., & Meng, X. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115260 · Cited by 24 · see citing works

The Oral–Gut–Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke

Zhong, Y., Kang, X., Bai, X., Pu, B., Smerin, D., Zhao, L., & Xiong, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70152 · Cited by 24 · see citing works

The gut–brain connection: microbes’ influence on mental health and psychological disorders

Ataei, P., Kalantari, H., Bodnar, T. S., & Turner, R. J. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1701608 · Cited by 32 · see citing works

Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression

Xinzhou, W., Cheng, L., Liu, Y., Zhang, R., Wu, Z., Weng, P., Zhang, P., & Zhang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.807076 · Cited by 24 · see citing works

Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats

Xu, D., Xu, Y., Gao, X., Yan, M., Zhang, C., Wu, X., Xia, Q., & Ge, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110903 · Cited by 25 · see citing works

The gut microbiota-brain connection: insights into major depressive disorder and bipolar disorder

Zhao, J. W., Liu, J., Feng, J., Liu, X., & Hu, Q. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1421490 · Cited by 25 · see citing works

Gut Microbiota: A New Challenge in Mood Disorder Research

Marano, G., Rossi, S., Sfratta, G., Traversi, G., Lisci, F. M., Anesini, M. B., Pola, R., Gasbarrini, A., Gaetani, E., & Mazza, M. (2025) · Life · doi:10.3390/life15040593 · Cited by 23 · see citing works

Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut–brain axis

Xie, Y., Wu, Z., Qian, Q., Yang, H., Ma, J., Luan, W., Shang, S., & Li, X. (2024) · Food & Function · doi:10.1039/d3fo04606k · Cited by 22 · see citing works

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Yoshioka, T., Ohashi, M., Matsumoto, K., Omata, T., Hamano, T., Yamazaki, M., Kimiki, S., Okano, K., Kobayashi, R., Yamada, D., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.993132 · Cited by 20 · see citing works

Fucoidans: Exploring its neuroprotective mechanisms and therapeutic applications in brain disorders

Batista, P., Cunha, S. A., Ribeiro, T. B., Borges, S., Baptista-Silva, S., Oliveira‐Silva, P., & Pintado, M. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104300 · Cited by 21 · see citing works

Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis

Wang, C., Su, Z., Dai, C.-G., Song, J., & Qian, B. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115041 · Cited by 20 · see citing works

The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?

Dohm-Hansen, S., Donoso, F., Lucassen, P. J., Clarke, G. A., & Nolan, Y. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105746 · Cited by 20 · see citing works

Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis

Meng, P., Zhang, X., Li, D., Yang, H., Lin, X., Zhao, H., Li, P., Wang, Y., Wang, X., & Ge, J. (2023) · Neural Plasticity · doi:10.1155/2023/1455634 · Cited by 19 · see citing works

Promising Antidepressant Potential: The Role of Lactobacillus rhamnosus GG in Mental Health and Stress Response

Işık, M., Köse, F., Özbayer, C., Budak, Ö., KELEŞ, R., Güzel, D., Demirci, M. A., Doğanay, S., & Bağcı, C. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10470-0 · Cited by 19 · see citing works

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

Han, W., Wang, N., Han, M., Ban, M., Sun, T., & Xu, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1029495 · Cited by 18 · see citing works

When the microbiome helps the brain‐current evidence

Drljača, J., Milosevic, N. P., Milanović, M., Abenavoli, L., & Milić, N. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14076 · Cited by 18 · see citing works

Fecal metabolomics combined with metagenomics sequencing to analyze the antidepressant mechanism of Yueju Wan

Qu, Z., Wu, S., Zheng, Y., Bing, Y., Liu, X., Li, S., Li, W., & Zou, X. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115807 · Cited by 17 · see citing works

Apple Polyphenol Extracts Attenuated Depressive-Like Behaviors of High-Sucrose Diet Feeding Mice by Farnesoid X Receptor-Mediated Modulation of Bile Acid Circulation within the Liver–Gut–Brain Axis

Xie, Y., Shang, S., Luan, W., Ma, J., Yang, H., Qian, Q., Wu, Z., & Li, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07035 · Cited by 17 · see citing works

Antidepressant Active Components of Bupleurum chinense DC‐Paeonia lactiflora Pall Herb Pair: Pharmacological Mechanisms

Lv, S., Zhao, Y., Wang, L., Yu, Y., Li, J., Huang, Y., Xu, W., Sun, G., Dai, W., Zhao, T., et al. (2022) · BioMed Research International · doi:10.1155/2022/1024693 · Cited by 17 · see citing works

Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis

Jain, M., Anand, A., Sharma, N., Shamim, M. A., & Enioutina, E. Y. (2024) · Nutrients · doi:10.3390/nu16203564 · Cited by 17 · see citing works

The Influence of the Gut Microbiota on Alzheimer's Disease: A Narrative Review

Yin, J.-T., Xu, X., Jin, C.-Y., Yuan, X., & Wang, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2202038 · Cited by 15 · see citing works

Microbiota-Gut-Brain Axis and Antidepressant Treatment

Lachmansingh, D. A., Lavelle, A., Cryan, J. F., & Clarke, G. A. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_449 · Cited by 16 · see citing works

Depression unveiled: Insights into etiology and animal models for behavioral assessment, exploring the multifactorial nature and treatment of depression

More, S. M., Kaleem, M., Kharwade, R., Almutairy, A. F., Shahzad, N., Mujtaba, M. A., Taha, M., Pise, A. G., Zafar, A., & Mahmood, D. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149313 · Cited by 16 · see citing works

Role of Bifidobacterium spp. intake in improving depressive mood and well-being and its link to kynurenine blood level: an interventional study

Kazem, Y. I., Mahmoud, M. H., Essa, H. A., Azmy, O. M., Kandeel, W. A., Al‐Moghazy, M., El-Attar, I., Hashish, A. F., & Mehanna, N. S. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2021-0351 · Cited by 15 · see citing works

Asiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota

Ren, Q., He, C., Sun, Y., Gao, X., Zhou, Y., Qin, T., Zhang, Z., Wang, X., Wang, J., Wei, S., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1461873 · Cited by 14 · see citing works

Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review

Xu, Y., Liu, L., Ma, Y., Wang, C., Duan, F., Feng, J., Yin, H., Sun, L., Cao, Z., Jung, J., et al. (2024) · Aquatic Toxicology · doi:10.1016/j.aquatox.2024.107215 · Cited by 16 · see citing works

Cingulate white matter mediates the effects of fecal Ruminococcus on neuropsychiatric symptoms in patients with amyloid-positive amnestic mild cognitive impairment

Hung, C.-C., Chao, Y., Lee, Y., Huang, C., Huang, S., Chang, C., & Cheng, C. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04417-9 · Cited by 13 · see citing works

Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm"

Xu, D., Hou, Z., Xu, Y., Liang, J., Gao, Y.-J., Zhang, C., Guo, F., Huang, D., Ge, J., & Xia, Q. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10103-3 · Cited by 13 · see citing works

The psychobiotic revolution: comprehending the optimistic role of gut microbiota on gut-brain axis during neurological and Gastrointestinal (GI) disorders

Mohiuddin, M., Asghar, T., Hameed, H., Din, A. M., Siddique, A., Younas, S., Din, M. M. U., & Ara, R. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04632-z · Cited by 13 · see citing works

Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut–brain axis

Adedara, I. A., Mohammed, K. A., Canzian, J., Ajayi, B. O., Farombi, E. O., Emanuelli, T., Rosemberg, D. B., & Aschner, M. (2024) · Advances in neurotoxicology · doi:10.1016/bs.ant.2024.02.003 · Cited by 12 · see citing works

Rapid shift of gut microbiome and enrichment of beneficial microbes during arhatic yoga meditation retreat in a single-arm pilot study

Swarup, S., Gupta, A., Chung, M., Radhakrishnan, V., Davis, V., Lynch, M. D. J., Charles, T. C., Cheng, J., & Mendoza, G. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04783-4 · Cited by 12 · see citing works

High GABA-producing Lactococcus lactis ZFM559 and its derived GABA alleviate chronic unpredictable mild stress (CUMS)-induced depression via the “microbiota–brain” axis

Han, J., Hu, S. Q., Zhao, X., Ding, L., Yin, J., Liu, J., Li, P., & Gu, Q. (2025) · Food & Function · doi:10.1039/d5fo02582f · Cited by 14 · see citing works

Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice

Li, X., He, C., Shen, M., Wang, M., Zhou, J., Chen, D., Zhang, T., & Pu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117331 · Cited by 11 · see citing works

New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside

Liu, M., Fan, G., Meng, L., Yang, K., & Liu, H. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300343 · Cited by 10 · see citing works

The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

Liang, C., Wei, S., Ji, Y., Lin, J., Jiao, W., Li, Z., Yan, F., & Xi, J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105931 · Cited by 9 · see citing works

Gut microbiota in anxiety and depression: mechanisms, drug interactions, and therapeutic implications

Fatimi, H. E., El‐Mansoury, B., Tinakoua, A., Ndayambaje, M., Zaid, Y., Khalki, H., & Khalki, L. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00759-w · Cited by 9 · see citing works

The complex interplay between psoriasis and depression: from molecular mechanisms to holistic treatment approaches

Wang, Y., Xing, J., Liang, Y., Liang, H., Niu, X., Li, J., & Zhang, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1659346 · Cited by 8 · see citing works

Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice

Ji, J., Yi, X., Gao, X., Wang, B., Zhang, X., Shen, X., & Xia, G. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13369 · Cited by 8 · see citing works

Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review

Zhang, Y., Liu, C., Zhu, Q., Wu, H. L., Liu, Z., & Zeng, L. (2025) · Nutrients · doi:10.3390/nu17020259 · Cited by 9 · see citing works

Adult hippocampal neurogenesis: pharmacological mechanisms of antidepressant active ingredients in traditional Chinese medicine

Lv, S., Zhang, G.-H., Huang, Y., Zhong, X., Yi, Y.-H., Lu, Y.-T., Li, J.-M., Ma, Y., & Teng, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1307746 · Cited by 7 · see citing works

“Gut feelings”: Pathways for influence of gut microbes on mood and behavior

Goehler, L. E. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.07.164

The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder

Młynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., & Rysz, J. (2022) · Nutrients · doi:10.3390/nu14091921 · Cited by 109 · see citing works

Microbiota-gut-brain Axis and its Role in Depression: A Narrative Review

Jangpangi, D., Deka, N., & Bajaj, S. (2026) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2026/80166.22960

Mechanisms linking gut microbiota to depression

Fraga, A., Esteves-Sousa, D., Facucho-Oliveira, J., Albuquerque, M., Costa, M., Espada-Santos, P., Moura, N., & Moutinho, A. (2021) · European Psychiatry · doi:10.1192/j.eurpsy.2021.1962 · Cited by 4 · see citing works

Gut Microbiota and Depression: Mechanistic Links Within the Gut–Brain Axis — A Narrative Review

Siwiec, K., Purwin, A., Lach, K., Kulach, A., Piekarska, P., Lamparski, Ł., Modrzejewska, W., Szmit, G., Basak, W., & Krok, G. (2026) · Archiv Euromedica · doi:10.35630/2026/16/iss.2.16