The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
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High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur in common myocardial diseases. Previous overexpression studies have shown that the inducible transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is capable of activating postnatal cardiac myocyte mitochondrial biogenesis. Recently, we generated mice deficient in PGC-1alpha (PGC-1alpha(-/-) mice), which survive with modestly blunted postnatal cardiac growth. To determine if PGC-1alpha is essential for normal cardiac energy metabolic capacity, mitochondrial function experiments were performed on saponin-permeabilized myocardial fibers from PGC-1alpha(-/-) mice. These experiments demonstrated reduced maximal (state 3) palmitoyl-l-carnitine respiration and increased maximal (state 3) pyruvate respiration in PGC-1alpha(-/-) mice compared with PGC-1alpha(+/+) controls. ATP synthesis rates obtained during maximal (state 3) respiration in permeabilized myocardial fibers were reduced for PGC-1alpha(-/-) mice, whereas ATP produced per oxygen consumed (ATP/O), a measure of metabolic efficiency, was decreased by 58% for PGC-1alpha(-/-) fibers. Ex vivo isolated working heart experiments demonstrated that PGC-1alpha(-/-) mice exhibited lower cardiac power, reduced palmitate oxidation, and increased reliance on glucose oxidation, with the latter likely a compensatory response. (13)C NMR revealed that hearts from PGC-1alpha(-/-) mice exhibited a limited capacity to recruit triglyceride as a source for lipid oxidation during beta-adrenergic challenge. Consistent with reduced mitochondrial fatty acid oxidative enzyme gene expression, the total triglyceride content was greater in hearts of PGC-1alpha(-/-) mice relative to PGC-1alpha(+/+) following a fast. Overall, these results demonstrate that PGC-1alpha is essential for the maintenance of maximal, efficient cardiac mitochondrial fatty acid oxidation, ATP synthesis, and myocardial lipid homeostasis.
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Whole-body PGC-1α-null mice consistently display 30-60% reductions in OXPHOS gene expression in muscle, normal to decreased mitochondrial density in skeletal muscle, and decreased cristae density in heart.
“These mice consistently display 30 -60% reductions in OXPHOS gene expression in muscle, normal to decreased mitochondrial density in skeletal muscle, and decreased cristae density in heart.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
Decreased metabolic efficiency may lead to enhanced whole-body fuel utilization and thus a leaner, more insulin-sensitive phenotype.
“For example, decreased metabolic efficiency (61), defined as decreased ATP produced per unit of oxidized fuel and/or oxygen, may lead to enhanced whole-body fuel utilization and thus a leaner, more insulin-sensitive phenotype.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
Functionally, whole-body PGC-1α-null mice show decreases in ATP levels, state 3 respiration, and metabolic efficiency, and cardiac and skeletal muscle performance is reduced in response to stress.
“Functionally, decreases in ATP levels, state 3 respiration, and metabolic efficiency are seen, and cardiac and skeletal muscle performance is reduced in response to stress.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,079 · see citing works
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594 · see citing works
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works
Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195 · see citing works
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · see citing works
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
Scarpulla, R. C. (2002) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(02)00343-3 · Cited by 631 · see citing works
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586 · see citing works
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556 · see citing works
St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works
Mitochondrial energy metabolism in heart failure: a question of balance
Huss, J. M., & Kelly, D. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24405 · Cited by 533 · see citing works
Kukidome, D., Nishikawa, T., Sonoda, K., Imoto, K., Fujisawa, K., Yano, M., Motoshima, H., Taguchi, T., Matsumura, T., & Araki, E. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0943 · Cited by 504 · see citing works
Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works
Huss, J. M., Kopp, R. P., & Kelly, D. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206324200 · Cited by 480 · see citing works
Schreiber, S., Knutti, D., Brogli, K., Uhlmann, T., & Kralli, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212923200 · Cited by 458 · see citing works
Garnier, A., Fortin, D., Deloménie, C., Momken, I., Veksler, V., & Ventura‐Clapier, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045104 · Cited by 423 · see citing works
Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410 · see citing works
Russell, L. K., Mansfield, C. M., Lehman, J. J., Kovacs, A., Courtois, M., Saffitz, J. E., Medeiros, D. M., Valencik, M. L., McDonald, J. A., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000117088.36577.eb · Cited by 402 · see citing works
Arany, Z., Novikov, M., Chin, S., Ma, Y., Rosenzweig, A., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603615103 · Cited by 374 · see citing works
Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo
Saks, V. A., Veksler, V., Kuznetsov, A. V., Kay, L., Sikk, P., Tiivel, T., Tranqui, L., Olivares, J., Winkler, K., Wiedemann, F. R., et al. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_7 · Cited by 361 · see citing works
Wende, A. R., Huss, J. M., Schaeffer, P. J., Giguère, V., & Kelly, D. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10684-10694.2005 · Cited by 354 · see citing works
Self-citationThe cristal membrane of mitochondria is the principal site of oxidative phosphorylation
Gilkerson, R., Selker, J. M. L., & Capaldi, R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00633-1 · Cited by 341 · see citing works
Regulation of Energy Metabolism of the Heart during Acute Increase in Heart Work
Goodwin, G. W., Taylor, C. S., & Taegtmeyer, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29530 · Cited by 323 · see citing works
Malloy, C. R., Sherry, A. D., & Jeffrey, F. M. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68590-4 · Cited by 322 · see citing works
Lee, C.-K., Allison, D. B., Brand, J., Weindruch, R., & Prolla, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232308999 · Cited by 314 · see citing works
Fisher, R. P., Lisowsky, T., Parisi, M. A., & Clayton, D. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50739-6 · Cited by 312 · see citing works
Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vitro
Veksler, V., Kuznetsov, A. V., Kay, L., Sikk, P., Tiivel, T., Tranqui, L., Olivares, J., Winkler, K., Wiedemann, F. R., & Kunz, W. S. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006834912257 · Cited by 308 · see citing works
Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes
Garesse, R., & Vallejo, C. G. (2001) · Gene · doi:10.1016/s0378-1119(00)00582-5 · Cited by 307 · see citing works
Beckman, K. B., & Ames, B. N. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50027-4 · Cited by 307 · see citing works
Virbasius, J. V., Virbasius, C.-M. A., & Scarpulla, R. C. (1993) · Genes & Development · doi:10.1101/gad.7.3.380 · Cited by 291 · see citing works
A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen
Knutti, D., Kaul, A., & Kralli, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2411-2422.2000 · Cited by 286 · see citing works
cDNA Cloning and mRNA Analysis of PGC-1 in Epitrochlearis Muscle in Swimming-Exercised Rats
Goto, M., Terada, S., Kato, M., Katoh, M., Yokozeki, T., Tabata, I., & Shimokawa, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3134 · Cited by 258 · see citing works
Lehman, J. J., & Kelly, D. P. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03655.x · Cited by 257 · see citing works
Self-citationHan, X., Yang, J., Cheng, H., Ye, H., & Gross, R. W. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.04.004 · Cited by 219 · see citing works
A fundamental system of cellular energy homeostasis regulated by PGC-1α
Rohas, L. M., St‐Pierre, J., Uldry, M., Jäger, S., Handschin, C., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702683104 · Cited by 210 · see citing works
Sorokina, N., O’Donnell, J. M., McKinney, R. D., Pound, K. M., Woldegiorgis, G., LaNoue, K. F., Ballal, K., Taegtmeyer, H., Buttrick, P. M., & Lewandowski, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.668665 · Cited by 193 · see citing works
Oxidative phosphorylation and aging
Lesnefsky, E. J., & Hoppel, C. L. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.001 · Cited by 190 · see citing works
Chiarugi, P., & Buricchi, F. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.1 · Cited by 171 · see citing works
Activation of cardiac Cdk9 represses PGC‐1 and confers a predisposition to heart failure
Sano, M., Wang, S. C., Shirai, M., Scaglia, F., Xie, M., Sakai, S., Tanaka, T., Kulkarni, P. A., Barger, P. M., Youker, K. A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600351 · Cited by 156 · see citing works
Borniquel, S., Valle, I., Cadenas, S., Lamas, S., & Monsalve, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5189fje · Cited by 147 · see citing works
Kim, H., Park, K., Yoo, E.-K., Kim, Y.-H., Kim, Y.-N., Kim, H., Kim, H. T., Park, J., Lee, K.-U., Jang, W. G., et al. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1456 · Cited by 136 · see citing works
Glucose and fatty acid metabolism in the isolated working mouse heart
Belke, D. D., Larsen, T. S., Lopaschuk, G. D., & Severson, D. L. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1210 · Cited by 130 · see citing works
Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart
Boehm, E. A., Jones, B. E., Radda, G. K., Veech, R. L., & Clarke, K. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.3.h977 · Cited by 128 · see citing works
O’Donnell, J. M., Fields, A. D., Sorokina, N., & Lewandowski, E. D. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.11.006 · Cited by 118 · see citing works
Burgess, S. C., Leone, T. C., Wende, A. R., Croce, M. A., Chen, Z., Sherry, A. D., Malloy, C. R., & Finck, B. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600050200 · Cited by 111 · see citing works
Laine, H. K., Katoh, C., Luotolahti, M., Yki‐Järvinen, H., Kantola, I. M., Jula, A., Takala, T., Ruotsalainen, U., Iida, H., Haaparanta‐Solin, M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.24.2425 · Cited by 107 · see citing works
Yu, X., White, L. T., Doumen, C., Damico, L. A., LaNoue, K. F., Alpert, N. M., & Lewandowski, E. D. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80080-9 · Cited by 105 · see citing works
Han, X., Cheng, H., Mancuso, D. J., & Gross, R. W. (2004) · Biochemistry · doi:10.1021/bi048307o · Cited by 88 · see citing works
Triacylglycerol turnover in isolated working hearts of acutely diabetic rats
Saddik, M., & Lopaschuk, G. D. (1994) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y94-157 · Cited by 74 · see citing works
Mitochondrial ATP Synthesis in Permeabilized Cells: Assessment of the ATP/O Valuesin Situ
Ouhabi, R., Boue-Grabot, M., & Mazat, J. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2776 · Cited by 70 · see citing works
Jové, M., Salla, J., Planavila, A., Cabrero, À., Michalik, L., Wahli, W., Laguna, J. C., & Vázquez‐Carrera, M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300208-jlr200 · Cited by 63 · see citing works
Fuentes, L. D. L., Soto, P. F., Cupps, B. P., Pasque, M. K., Herrero, P., Gropler, R. J., Waggoner, A. D., & Dávila‐Román, V. G. (2006) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2006.01.021 · Cited by 55 · see citing works
O’Donnell, J. M., Zampino, M., Alpert, N. M., Fasano, M. J., Geenen, D. L., & Lewandowski, E. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00139.2005 · Cited by 51 · see citing works
Nielsen, L. B., Perko, M. J., Arendrup, H. C., & Andersen, C. B. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000030199.06252.26 · Cited by 47 · see citing works
Coupling of Mitochondrial Fatty Acid Uptake to Oxidative Flux in the Intact Heart
O’Donnell, J. M., Alpert, N. M., White, L. T., & Lewandowski, E. D. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75369-1 · Cited by 43 · see citing works
Benton, C. R., Han, X., Febbraio, M., Graham, T. E., & Bonen, A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00781.2005 · Cited by 33 · see citing works
Rodrigue‐Way, A., Demers, A., Ong, H., & Tremblay, A. (2006) · Endocrinology · doi:10.1210/en.2006-0975 · Cited by 32 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [24]Huss JM, Kopp RP, Kelly DP. PGC-1α coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ. J Biol Chem 277: 40265–40274, 2002. [DOI] [PubMed] [Google Scholar]
- [25]Huss JM, Pinéda Torra I, Staels B, Giguère V, Kelly DP. ERRα directs PPARα signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol 24: 9079–9091, 2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [28]Knutti D, Kaul A, Kralli A. A tissue-specific coactivator of steroid receptors. Mol Cell Biol 20: 2411–2422, 2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [33]Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros D, Kelly DP. PPARγ coactivator-1 (PGC-1) promotes cardiac mitochondrial biogenesis. J Clin Invest 106: 847–856, 2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 648 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
Energy metabolism in heart failure and remodelling
Ingwall, J. S. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn301 · Cited by 462 · see citing works
Schirone, L., Forte, M., Palmerio, S., Yee, D., Nocella, C., Angelini, F., Pagano, F., Schiavon, S., Bordin, A., Carrizzo, A., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3920195 · Cited by 432 · see citing works
Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works
PGC-1 Coactivators in Cardiac Development and Disease
Rowe, G. C., Jiang, A., & Arany, Z. P. (2010) · Circulation Research · doi:10.1161/circresaha.110.223818 · Cited by 355 · see citing works
Legchenko, E., Chouvarine, P., Borchert, P., Fernandez‐Gonzalez, A., Snay, E. R., Meier, M., Maegel, L., Mitsialis, S. A., Rog‐Zielinska, E. A., Kourembanas, S., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0303 · Cited by 295 · see citing works
Palomer, X., Salvadó, L., Barroso, E., & Vázquez‐Carrera, M. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.150 · Cited by 289 · see citing works
Mitochondria in cardiac hypertrophy and heart failure
Rosca, M. G., Tandler, B., & Hoppel, C. L. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.09.002 · Cited by 266 · see citing works
Doenst, T., Pytel, G., Schrepper, A., Amorim, P., Färber, G., Shingu, Y., Mohr, F. W., & Schwarzer, M. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp414 · Cited by 246 · see citing works
Bioenergetics of the failing heart
Ventura‐Clapier, R., Garnier, A., Veksler, V., & Joubert, F. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.006 · Cited by 233 · see citing works
Role of nuclear receptor SHP in metabolism and cancer
Zhang, Y., Hagedorn, C. H., & Wang, L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.10.006 · Cited by 235 · see citing works
Coactivators in PPAR-Regulated Gene Expression
Viswakarma, N., Jia, Y., Bai, L., Vluggens, A., Borensztajn, J., Xu, J., & Reddy, J. K. (2010) · PPAR Research · doi:10.1155/2010/250126 · Cited by 232 · see citing works
Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B., et al. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2940 · Cited by 215 · see citing works
PGC-1α and ERRα target gene downregulation is a signature of the failing human heart
Sihag, S., Cresci, S., Li, A. Y., Sucharov, C. C., & Lehman, J. J. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.025 · Cited by 212 · see citing works
Metabolic Origins of Heart Failure
Wende, A. R., Brahma, M. K., McGinnis, G. R., & Young, M. E. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2016.11.009 · Cited by 208 · see citing works
Schugar, R. C., Moll, A. R., d’Avignon, D. A., Weinheimer, C. J., Kovács, A. D., & Crawford, P. A. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.07.010 · Cited by 187 · see citing works
Álvarez-Guardia, D., Palomer, X., Coll, T., Davidson, M. M., Chan, T. O., Feldman, A. M., Laguna, J. C., & Vázquez‐Carrera, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq080 · Cited by 187 · see citing works
Gomez‐Arroyo, J. G., Mizuno, S., Szczepanek, K., Tassell, B. W. V., Natarajan, R., dos Remedios, C. G., Drake, J. I., Farkas, L., Kraskauskas, D., Wijesinghe, D. S., et al. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.111.966127 · Cited by 176 · see citing works
Mitochondrial NAD + /NADH Redox State and Diabetic Cardiomyopathy
Berthiaume, J. M., Kurdys, J., Muntean, D. M., & Rosca, M. G. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7415 · Cited by 168 · see citing works
Wang, Y., Feng, W., Xue, W., Tan, Y., Hein, D. W., Li, X., & Cai, L. (2009) · Diabetes · doi:10.2337/db08-1697 · Cited by 166 · see citing works
Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging
Saheera, S., & Krishnamurthy, P. (2020) · Cell Transplantation · doi:10.1177/0963689720920830 · Cited by 165 · see citing works
Banke, N. H., Wende, A. R., Leone, T. C., O’Donnell, J. M., Abel, E. D., Kelly, D. P., & Lewandowski, E. D. (2010) · Circulation Research · doi:10.1161/circresaha.110.221713 · Cited by 160 · see citing works
Mitochondrial SIRT3 and heart disease
Pillai, V. B., Sundaresan, N. R., Jeevanandam, V., & Gupta, M. P. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq250 · Cited by 160 · see citing works
PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy
Riehle, C., Wende, A. R., Zaha, V. G., Pires, K. M. P., Wayment, B. E., Olsen, C. D., Bugger, H., Buchanan, J., Wang, X., Moreira, A. B., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243964 · Cited by 156 · see citing works
Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart
Desai, M. S., Mathur, B., Eblimit, Z., Vasquez, H., Taegtmeyer, H., Karpen, S. J., Penny, D. J., Moore, D. D., & Anakk, S. (2016) · Hepatology · doi:10.1002/hep.28890 · Cited by 149 · see citing works
Telomeres and Mitochondria in the Aging Heart
Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 150 · see citing works
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
Sakamoto, T., Matsuura, T. R., Wan, S., Ryba, D. M., Kim, J., Won, K., Lai, L., Petucci, C. J., Petrenko, N. B., Musunuru, K., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316100 · Cited by 144 · see citing works
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells
Koyama, T., Kume, S., Koya, D., Araki, S., Isshiki, K., Chin‒Kanasaki, M., Sugimoto, T., Haneda, M., Sugaya, T., Kashiwagi, A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.028 · Cited by 142 · see citing works
Effector T cells require fatty acid metabolism during murine graft-versus-host disease
Byersdorfer, C. A., Tkachev, V., Opipari, A. W., Goodell, S., Swanson, J. B., Sandquist, S., Glick, G. D., & Ferrara, J. L. M. (2013) · Blood · doi:10.1182/blood-2013-04-495515 · Cited by 136 · see citing works
Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism
Prosdocimo, D. A., Anand, P., Liao, X., Zhu, H., Shelkay, S., Artero, P. C., Zhang, L., Kirsh, J., Moore, D., Rosca, M. G., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531384 · Cited by 132 · see citing works
Chandrasekaran, K., Anjaneyulu, M., Choi, J., Kumar, P., Salimian, M., Ho, C.-Y., & Russell, J. W. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.04.002 · Cited by 131 · see citing works
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
Fukuda, R., Marín‐Juez, R., El‐Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C. T., Günther, S., Konzer, A., Bhagwat, A. M., Graumann, J., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949752 · Cited by 119 · see citing works
PGC-1 coactivators in the cardiovascular system
Patten, I. S., & Arany, Z. P. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.09.007 · Cited by 119 · see citing works
The role of PGC‐1 coactivators in aging skeletal muscle and heart
Dillon, L. M., Rebelo, A. P., & Moraes, C. T. (2012) · IUBMB Life · doi:10.1002/iub.608 · Cited by 116 · see citing works
Abdurrachim, D., Luiken, J. J. F. P., Nicolay, K., Glatz, J. F. C., Prompers, J. J., & Nabben, M. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv105 · Cited by 110 · see citing works
PGC-1 Proteins and Heart Failure
Riehle, C., & Abel, E. D. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.07.003 · Cited by 108 · see citing works
Xu, Z., Huo, J., Ding, X., Yang, M., Li, L., Dai, J., Hosoe, K., Kubo, H., Mori, M., Higuchi, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08899-7 · Cited by 108 · see citing works
Murine Electrophysiological Models of Cardiac Arrhythmogenesis
Huang, C. L.-H. (2016) · Physiological Reviews · doi:10.1152/physrev.00007.2016 · Cited by 105 · see citing works
The PGC-1 cascade as a therapeutic target for heart failure
Schilling, J. D., & Kelly, D. P. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.09.021 · Cited by 105 · see citing works
Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle
Sun, Z., Singh, N., Mullican, S. E., Everett, L. J., Li, L., Yuan, L., Liu, X., Epstein, J. A., & Lazar, M. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277707 · Cited by 103 · see citing works
Nutrient sensing and the circadian clock
Peek, C. B., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.02.003 · Cited by 103 · see citing works
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
Yamamoto, T., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020996 · Cited by 102 · see citing works
Mitochondrial biogenesis in cardiac pathophysiology
Rimbaud, S., Garnier, A., & Ventura‐Clapier, R. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70015-5 · Cited by 98 · see citing works
Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure
Gupte, A. A., Hamilton, D. J., Cordero‐Reyes, A. M., Youker, K. A., Yin, Z., Estep, J. D., Stevens, R. D., Wenner, B. R., Ilkayeva, O., Loebe, M. M., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000404 · Cited by 94 · see citing works
Vazquez, E. J., Berthiaume, J. M., Kamath, V. G., Achike, O., Buchanan, E., Montano, M. M., Chandler, M. P., Miyagi, M., & Rosca, M. G. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv183 · Cited by 91 · see citing works
Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK
Shimizu, Y., Polavarapu, R., Eskla, K., Nicholson, C. K., Koczor, C. A., Wang, R., Lewis, W., Shiva, S., Lefer, D. J., & Calvert, J. W. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.011 · Cited by 88 · see citing works
Metabolic remodeling in hypertrophied and failing myocardium: a review
Peterzan, M. A., Lygate, C. A., Neubauer, S., & Rider, O. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00731.2016 · Cited by 88 · see citing works
Nediani, C., Raimondi, L., Borchi, E., & Cerbai, E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3198 · Cited by 83 · see citing works
Regulation of Hypoxia-Inducible Genes by PGC-1α
Shoag, J., & Arany, Z. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181636 · Cited by 96 · see citing works
Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity
Liang, H., Balas, B., Tantiwong, P., Dube, J., Goodpaster, B. H., O'Doherty, R. M., DeFronzo, R. A., Richardson, A., Musi, N., & Ward, W. F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90292.2008 · Cited by 81 · see citing works
Multiple Levels of PGC-1α Dysregulation in Heart Failure
Oka, S., Sabry, A. D., Cawley, K. M., & Warren, J. S. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00002 · Cited by 81 · see citing works
Choi, J., Ravipati, A., Nimmagadda, V. K. C., Schubert, M., Castellani, R. J., & Russell, J. W. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.09.005 · Cited by 77 · see citing works
Cardiac nuclear receptors: architects of mitochondrial structure and function
Vega, R. B., & Kelly, D. P. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88888 · Cited by 71 · see citing works
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension
Zelt, J. G. E., Chaudhary, K. R., Cadete, V. J. J., Mielniczuk, L. M., & Stewart, D. J. (2019) · Circulation Research · doi:10.1161/circresaha.118.313650 · Cited by 70 · see citing works
PGC‐1α, a potential therapeutic target against kidney aging
Lee, G.-Y., Uddin, M. J., Kim, Y., Ko, M., Yu, I., & Ha, H. (2019) · Aging Cell · doi:10.1111/acel.12994 · Cited by 71 · see citing works
Sun, W., Yang, J., Wang, W., Hou, J., Cheng, Y., Fu, Y., Xu, Z., & Cai, L. (2017) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2017.12.005 · Cited by 69 · see citing works
Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration
Song, C., Hu, P., Peng, R., Li, F., Fang, Z., & Xu, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107119 · Cited by 68 · see citing works
Tracing Cardiac Metabolism In Vivo: One Substrate at a Time
Taegtmeyer, H. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068205 · Cited by 66 · see citing works
New Drugs and Therapies in Pulmonary Arterial Hypertension
Shah, A. J., Beckmann, T., Vorla, M., & Kalra, D. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065850 · Cited by 63 · see citing works
Padmanabhan, A., Alexanian, M., Linares-Saldana, R., González-Terán, B., Andreoletti, G., Huang, Y., Connolly, A. J., Kim, W., Hsu, A., Duan, Q., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.047753 · Cited by 60 · see citing works
An, C.-I., Dong, Y., & Hagiwara, N. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-59 · Cited by 56 · see citing works
Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure
Rennison, J. H., McElfresh, T. A., Chen, X., Anand, V. R., Hoit, B. D., Hoppel, C. L., & Chandler, M. P. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.02.019 · Cited by 52 · see citing works
Pereira, R. O., Wende, A. R., Crum, A., Hunter, D., Olsen, C. D., Rawlings, T. A., Riehle, C., Ward, W. F., & Abel, E. D. (2014) · The FASEB Journal · doi:10.1096/fj.14-253823 · Cited by 53 · see citing works
Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M., & Crawford, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074806 · Cited by 52 · see citing works
Gupta, A. K., & Houston, B. A. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9623-6 · Cited by 50 · see citing works
SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart
Zhang, J., Ren, D., Fedorova, J., He, Z., & Li, J. (2020) · Antioxidants · doi:10.3390/antiox9090858 · Cited by 50 · see citing works
Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy
Romashko, M. D., Schragenheim, J., Abraham, N. G., & McClung, J. A. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.08.001 · Cited by 50 · see citing works
Sun, L.-Y., Wang, N., Ban, T., Sun, Y.-H., Han, Y., Sun, L., Yan, Y., Kang, X., Chen, S., Sun, L., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.06.012 · Cited by 48 · see citing works
Variation in the ACE, PPARGC1A and PPARA genes in Lithuanian football players
Ginevičienė, V., Jakaitienė, A., Tūbelis, L., & Kučinskas, V. (2012) · European Journal of Sport Science · doi:10.1080/17461391.2012.691117 · Cited by 47 · see citing works
Mitra, M. S., Schilling, J. D., Wang, X., Jay, P. Y., Huss, J. M., Su, X., & Finck, B. N. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.04.009 · Cited by 47 · see citing works
Zhou, Q., Xu, H., Liang, Y., Liang, Y., Zhang, X., Tan, B., Yi, Q., Tian, J., & Zhu, J. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.12.006 · Cited by 46 · see citing works
Hu, C., Ge, F., Hyodo, E., Arai, K., Iwata, S., Lobdell, H., Walewski, J. L., Zhou, S., Clugston, R. D., Jiang, H., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.02.005 · Cited by 46 · see citing works
Fernyhough, P., & McGavock, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00027-8 · Cited by 47 · see citing works
Whitehead, N., Gill, J. F., Brink, M., & Handschin, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00242 · Cited by 44 · see citing works
Hankiewicz, J. H., Banke, N. H., Farjah, M., & Lewandowski, E. D. (2010) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.110.959098 · Cited by 42 · see citing works
She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55557-4 · Cited by 44 · see citing works
Liu, Q., Ma, R., Li, S., Fei, Y., Lei, J., Li, R., Pan, Y., Liu, S., & Wang, L. (2022) · Foods · doi:10.3390/foods11070942 · Cited by 40 · see citing works
Fritah, A., Steel, J. H., Nichol, D., Parker, N., Williams, S., Price, A. N., Strauss, L., Ryder, T. A., Mobberley, M. A., POUTANEN, M. H., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvp418 · Cited by 40 · see citing works
Zhao, Y., Tan, Y., Dai, J., Wang, B., Li, B., Guo, L., Cui, J., Wang, G., Li, W., & Cai, L. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.05.011 · Cited by 39 · see citing works
PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p
Ma, M., Cai, B., Kong, S., Zhou, Z., Zhang, J., Zhang, X., & Nie, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179575 · Cited by 38 · see citing works
Exercise, exerkines, and cardiometabolic health: from individual players to a team sport
Robbins, J., & Gerszten, R. E. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168121 · Cited by 41 · see citing works
Imaging Myocardial Metabolic Remodeling
Gropler, R. J., Beanlands, R. S., Dilsizian, V., Lewandowski, E. D., Villanueva, F. S., & Ziadi, M. C. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068197 · Cited by 38 · see citing works
Animal Models of Dysregulated Cardiac Metabolism
Bugger, H., Byrne, N. J., & Abel, E. D. (2022) · Circulation Research · doi:10.1161/circresaha.122.320334 · Cited by 37 · see citing works
Hoshino, D., Yoshida, Y., Holloway, G. P., Lally, J., Hatta, H., & Bonen, A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2011 · Cited by 37 · see citing works
Tabbi‐Anneni, I., Cooksey, R. C., Gunda, V., Liu, S., Mueller, A., Song, G., McClain, D. A., & Wang, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00655.2009 · Cited by 35 · see citing works
The role of triacylglycerol in cardiac energy provision
Evans, R. D., & Hauton, D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.010 · Cited by 35 · see citing works
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
Ivy, J. R., Carter, R. N., Zhao, J., Buckley, C., Urquijo, H., Rog‐Zielinska, E. A., Panting, E., Hrabálková, L., Nicholson, C., Agnew, E. J., et al. (2021) · The Journal of Physiology · doi:10.1113/jp281860 · Cited by 35 · see citing works
Chambers, K. T., Chen, Z., Crawford, P. A., Fu, X., Burgess, S. C., Lai, L., Leone, T. C., Kelly, D. P., & Finck, B. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052645 · Cited by 33 · see citing works
Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36
Carley, A. N., Bi, J., Wang, X., Banke, N. H., Dyck, J. R. B., O’Donnell, J. M., & Lewandowski, E. D. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m029991 · Cited by 32 · see citing works
Hypoxia-induced PGC-1α Regulates Mitochondrial Function and Tumorigenesis of Colorectal Cancer Cells
Yun, C. W., Lee, J. H., & Lee, S. H. (2019) · Anticancer Research · doi:10.21873/anticanres.13672 · Cited by 32 · see citing works
Lou, P., Zhang, L., Lucchinetti, E., Heck, M., Affolter, A., Gandhi, M., Kienesberger, P. C., Hersberger, M., Clanachan, A. S., & Zaugg, M. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs323 · Cited by 30 · see citing works
Al-Hasan, Y. M., Pinkas, G. A., & Thompson, L. P. (2014) · Reproductive Sciences · doi:10.1177/1933719113518981 · Cited by 29 · see citing works
Myocardial Fatty Acid Metabolism and Lipotoxicity in the Setting of Insulin Resistance
Kok, B. P., & Brindley, D. N. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.008 · Cited by 29 · see citing works
Jang, Y., Kwon, I., Song, W., Cosío-Lima, L., Taylor, S. M., & Lee, Y. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.045 · Cited by 28 · see citing works
A role for focal adhesion kinase in cardiac mitochondrial biogenesis induced by mechanical stress
Tornatore, T. F., Costa, A. P. D., Clemente, C. F. M. Z., Judice, C. C., Rocco, S. A., Calegari, V. C., Cardoso, L., Cardoso, A. C., Gonçalves, A., & Franchini, K. G. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00319.2010 · Cited by 28 · see citing works
Mao, S., Zhang, X., Chen, M., Wang, C., Chen, Q., Guo, L., Zhang, M., & Hinek, A. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07047-0 · Cited by 27 · see citing works
Banke, N. H., & Lewandowski, E. D. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.10.015 · Cited by 27 · see citing works
Feng, H., Wang, J., Zheng, M., Zhang, C., An, Y., Li, L., & Wu, L. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.02.001 · Cited by 25 · see citing works
- Authors
- Lehman, J. J., Boudina, S., Banke, N. H., Sambandam, N., Han, X., Young, D. M., Leone, T. C., Gross, R. W., Lewandowski, E. D., Abel, E. D., & Kelly, D. P.
- Affiliations
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Illinois Chicago (US)
- ORCID
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 295
- Issue
- 1
- Pages
- H185-H196
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2494758
- OpenAlex
- W2099192357
- Cited by
- 158
- References
- 64
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 16 · 2019: 4 · 2018: 8 · 2017: 15 · 2016: 6 · 2015: 2 · 2014: 12 · 2013: 6 · 2012: 16
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K08AG024844)
- National Heart, Lung, and Blood Institute (R01HL073167, R01-HL-73167, R37HL049244, R01HL058493, R01-HL-3749244)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341, P30DK052574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PGC-1α, myocardial energy metabolism, mitochondrial biogenesis, palmitate oxidation, triglyceride mobilization, beta-adrenergic stimulation, cardiac power output
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adenosine Triphosphate, Adrenergic beta-Agonists, Animals, Energy Metabolism, Fatty Acids, Female, Glucose, Homeostasis, Isoproterenol, Male, Mitochondria, Heart, Myocardial Contraction, Myocardium, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxidative Phosphorylation, Oxygen Consumption, Palmitoylcarnitine, Transcription Factors, Triglycerides, Trans-Activators, Mice, Knockout, Pyruvic Acid, Mice, In Vitro Techniques
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