Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood

Jenkins, Nathaniel D. M.; Rogers, Emily M.; Banks, Nile F.; Tomko, Patrick M.; Sciarrillo, Christina M.; Emerson, Sam R.; Taylor, Ashlee; Teague, T. Kent

doi:10.1152/ajpheart.00123.2021

Cited by 44Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionChild Abuse and Trauma

Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood

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Jenkins, Nathaniel D. M., Rogers, Emily M., Banks, Nile F., Tomko, Patrick M., Sciarrillo, Christina M., Emerson, Sam R., Taylor, Ashlee, Teague, T. Kent·2021·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.00123.2021PMC PMC8461842

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Abstract

Our study provides novel evidence that young adult women with moderate-to-severe adverse childhood experience (ACE) exposure present impaired endothelial function and lower circulating sirtuin 1 (SIRT1) concentrations than age-matched controls. However, an 8-wk exercise intervention was unable to augment endothelial function or SIRT1 concentrations in a subset of those with ACEs. Our data suggest that ACEs-related impairments in endothelial function may be secondary to decreased NO bioavailability via SIRT1 and/or oxidative stress-related mechanisms.

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Chronic psychosocial stress exposure, including exposure to adverse childhood experiences or social or socioeconomic stress, promotes increased lifetime risk of cardiometabolic diseases such as type 2 diabetes, obesity, and cardiovascular disease.
“chronic psychosocial stress exposure, including exposure to adverse childhood experiences (ACEs) or social or socioeconomic stress, promotes increased lifetime risk of cardiometabolic diseases such as T2D, 131-133 obesity, 134,135 and cardiovascular disease.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [119]

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Prevalence of adverse childhood experiences from the 2011-2014 behavioral risk factor surveillance system in 23 states
Merrick, M. T., Ford, D. C., Ports, K. A., & Guinn, A. S. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.2537 · Cited by 1,189 · see citing works
Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.214 · Cited by 1,165 · see citing works
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000267723.65696.4a · Cited by 1,147 · see citing works
Adverse childhood experiences and associated health outcomes: A systematic review and meta-analysis
Petruccelli, K., Davis, J. J., & Berman, T. (2019) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2019.104127 · Cited by 1,049 · see citing works
Insights Into Causal Pathways for Ischemic Heart Disease: Adverse Childhood Experiences Study
Dong, M., Giles, W. H., Felitti, V. J., Dube, S. R., Williams, J. E., Chapman, D. P., & Anda, R. F. (2004) · Circulation · doi:10.1161/01.cir.0000143074.54995.7f · Cited by 1,027 · see citing works
SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881 · see citing works
Childhood Adversity and Adult Chronic Disease
Gilbert, L. K., Breiding, M. J., Merrick, M. T., Thompson, W., Ford, D. C., Dhingra, S. S., & Parks, S. E. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.09.006 · Cited by 615 · see citing works
Shear Stress Mediates Endothelial Adaptations to Exercise Training in Humans
Tinken, T. M., Thijssen, D. H. J., Hopkins, N. D., Dawson, E. A., Cable, N. T., & GREEN, D. J. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146282 · Cited by 496 · see citing works
Exercise training enhances endothelial function in young men
Clarkson, P., Montgomery, H., Mullen, M. J., Donald, A. E., Powe, A. J., Bull, T., Jubb, M., WORLD, M. J., & Deanfield, J. E. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00036-4 · Cited by 458 · see citing works
The ‘Maltreatment and Abuse Chronology of Exposure’ (MACE) Scale for the Retrospective Assessment of Abuse and Neglect During Development
Teicher, M. H., & Parigger, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117423 · Cited by 421 · see citing works
Role of oxidative stress and nitric oxide in atherothrombosis
Lubos, E. (2008) · Frontiers in bioscience · doi:10.2741/3084 · Cited by 290 · see citing works
Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells
Zhang, W., Huang, Q., Zeng, Z., Wu, J., Zhang, Y., & Chen, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7543973 · Cited by 276 · see citing works
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Kitada, M., Ogura, Y., & Koya, D. (2016) · Aging · doi:10.18632/aging.101068 · Cited by 270 · see citing works
Aerobic exercise training and vascular function with ageing in healthy men and women
Seals, D. R., Nagy, E., & Moreau, K. L. (2019) · The Journal of Physiology · doi:10.1113/jp277764 · Cited by 231 · see citing works
Adverse Childhood Experiences and Blood Pressure Trajectories From Childhood to Young Adulthood
Su, S., Wang, X., Pollock, J. S., Treiber, F. A., Xu, X., Snieder, H., McCall, W. V., Stefanek, M. E., & Harshfield, G. A. (2015) · Circulation · doi:10.1161/circulationaha.114.013104 · Cited by 226 · see citing works
Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort
Barboza‐Solís, C., Kelly‐Irving, M., Fantin, R., Darnaudéry, M., Torrisani, J., Lang, T., & Delpierre, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417325112 · Cited by 216 · see citing works
SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
Zarzuelo, M. J., López-Sepúlveda, R., Sánchez, M., Romero, M., Gómez-Guzmán, M., Ungvary, Z., Pérez-Vizcaíno, F., Jiménez, R., & Duarte, J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.015 · Cited by 202 · see citing works
Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults
Sawyer, B. J., Tucker, W. J., Bhammar, D. M., Ryder, J. R., Sweazea, K. L., & Gaesser, G. A. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00024.2016 · Cited by 182 · see citing works
Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease
Brendle, D. C., Joseph, L., Corretti, M. C., Gardner, A. W., & Katzel, L. I. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01367-9 · Cited by 166 · see citing works
Childhood Maltreatment and Health Impact: The Examples of Cardiovascular Disease and Type 2 Diabetes Mellitus in Adults
Basu, A., McLaughlin, K., Misra, S., & Koenen, K. (2017) · Clinical Psychology · doi:10.1111/cpsp.12191 · Cited by 153 · see citing works
Age and sex affect human muscle fibre adaptations to heavy-resistance strength training
Martel, G. F., Roth, S. M., Ivey, F. M., Lemmer, J. T., Tracy, B. L., Hurlbut, D. E., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2005.032771 · Cited by 149 · see citing works
Females have a blunted cardiovascular response to one year of intensive supervised endurance training
Howden, E. J., Perhonen, M. A., Peshock, R. M., Zhang, R., Arbab‐Zadeh, A., ADAMS-HUET, B. A., & Levine, B. D. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00092.2015 · Cited by 138 · see citing works
Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives
McGowan, C. L. M., Visocchi, A., Faulkner, M., Verduyn, R., Rakobowchuk, M., Levy, A. S., McCartney, N., & MacDonald, M. J. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0282-x · Cited by 137 · see citing works
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Yuyun, M. F., Ng, L. L., & Ng, G. A. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.03.012 · Cited by 114 · see citing works
Exercise training improves endothelial function in young prehypertensives
Beck, D. T., Casey, D. P., Martin, J. S., Emerson, B. D., & Braith, R. W. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213477600 · Cited by 108 · see citing works
Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training
Okamoto, T., Masuhara, M., & Ikuta, K. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00327.2007 · Cited by 105 · see citing works
Adverse Childhood Experiences Are Associated With Detrimental Hemodynamics and Elevated Circulating Endothelin-1 in Adolescents and Young Adults
Su, S., Wang, X., Kapuku, G. K., Treiber, F. A., Pollock, D. M., Harshfield, G. A., McCall, W. V., & Pollock, J. S. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02755 · Cited by 98 · see citing works
Gender differences in the association of adult hopelessness with adverse childhood experiences
Haatainen, K. M., Tanskanen, A. J., Kylmä, J., Honkalampi, K. M., Koivumaa-Honkanen, H., Hintikka, J., Antikainen, R., & Viinamäki, H. T. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0598-3 · Cited by 91 · see citing works
Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
Lai, C., Ho, T., Kuo, W., Day, C. H., Pai, P., Chung, L.-C., Liao, P., Lin, F., Wu, E.-T., & Huang, C. (2014) · AGE · doi:10.1007/s11357-014-9706-4 · Cited by 77 · see citing works
Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice
Gioscia‐Ryan, R. A., Clayton, Z. S., Zigler, M. C., Richey, J. J., Cuevas, L. M., Rossman, M. J., Battson, M. L., Ziemba, B. P., Hutton, D. A., VanDongen, N. S., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280607 · Cited by 68 · see citing works
The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation
Russomanno, G., Corbi, G., Manzo, V., Ferrara, N., Rengo, G., Puca, A. A., Latte, S., Carrizzo, A., Calabrese, M. C., Andriantsitohaina, R., et al. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0088-1 · Cited by 57 · see citing works
Exercise training improves vascular function in adolescents with type 2 diabetes
Naylor, L. H., Davis, E. A., Kalic, R. J., Paramalingam, N., Abraham, M. B., Jones, T. W., & GREEN, D. J. (2016) · Physiological Reports · doi:10.14814/phy2.12713 · Cited by 54 · see citing works
Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients
Mariani, S., Giorgio, M. R. D., Martini, P., Persichetti, A., Bárbaro, G., Basciani, S., Contini, S., Poggiogalle, E., Sarnicola, A., Genco, A., et al. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00449 · Cited by 50 · see citing works
The effect of 48 weeks of aerobic exercise training on cutaneous vasodilator function in post-menopausal females
Hodges, G. J., Sharp, L. K., Stephenson, C. E., Patwala, A., George, K., Goldspink, D. F., & Cable, N. T. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1330-0 · Cited by 46 · see citing works
Gender Differences in the Association between Adverse Childhood Experiences and Cancer
Alcalá, H. E., Tomiyama, A. J., & Ehrenstein, O. S. V. (2017) · Women s Health Issues · doi:10.1016/j.whi.2017.06.002 · Cited by 45 · see citing works
Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood
Ho, D. H., Burch, M. L., Musall, B., Musall, J. B., Hyndman, K. A., & Pollock, J. S. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00016.2016 · Cited by 34 · see citing works
The impact of age on vascular smooth muscle function in humans
Montero, D., Pierce, G. L., Stehouwer, C. D. A., Padilla, J., & Thijssen, D. H. J. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000446 · Cited by 33 · see citing works
Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice.
Eller, O. C., Morris, E. M., Thyfault, J. P., & Christianson, J. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113000 · Cited by 28 · see citing works
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
Gurd, B. J., & Williams, C. (2012) · The Application of Clinical Genetics · doi:10.2147/tacg.s31276 · Cited by 24 · see citing works
The acute effect of resistance exercise on limb blood flow
Thomas, K. N., Kissling, L. S., Gibbons, T. D., Akerman, A. P., van Rij, A. M., & Cotter, J. D. (2020) · Experimental Physiology · doi:10.1113/ep088743 · Cited by 21 · see citing works
Sirt1 during childhood is associated with microvascular function later in life
Rodriguez‐Miguelez, P., Looney, J. C., Thomas, J., Harshfield, G. A., Pollock, J. S., & Harris, R. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00024.2020 · Cited by 20 · see citing works
Increases in motor unit action potential amplitudes are related to muscle hypertrophy following eight weeks of high‐intensity exercise training in females
Jenkins, N. D. M., Rogers, E. M., Banks, N. F., Muddle, T. W. D., & Colquhoun, R. J. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1836262 · Cited by 18 · see citing works
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Craighead, D. H., Freeberg, K. A., & Seals, D. R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016625 · Cited by 15 · see citing works
Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial
Lekavich, C. L., Allen, J. D., Bensimhon, D., Bateman, L. A., Slentz, C. A., Samsa, G. P., Kenjale, A. A., Duscha, B. D., Douglas, P. S., & Kraus, W. E. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.638929 · Cited by 13 · see citing works
Reproducible improvement in endothelial function following two separate periods of high-intensity interval training in young men
Williams, J. S., Giudice, M. D., Gurd, B. J., & Pyke, K. E. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00054.2020 · Cited by 10 · see citing works
Non-INvasive Functional and Anatomic vascular evaluation for the prediction of coronary artery disease: The NINFA study
Mangiacapra, F., Bressi, E., Viscusi, M. M., Creta, A., Gioia, G. D., Capuano, M., Colaiori, I., Sciascio, G. D., Ussia, G. P., & Grigioni, F. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.08.038 · Cited by 6 · see citing works
The Impact of Different Exercise Intensities on Vasodilation and Shear Rate Patterns in Children
McManus, A. M., Sletten, N. R., & GREEN, D. J. (2019) · Pediatric Exercise Science · doi:10.1123/pes.2019-0003 · Cited by 4 · see citing works

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Abstract MP17: Circulating Sirt1 And Endothelial Function Are Lower, But Are Not Improved By 8-weeks Of Exercise Training, In Young Adult Females With A History Of Adverse Childhood Experiences.
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Su, S., Wang, X., Kapuku, G. K., Treiber, F. A., Pollock, D. M., Harshfield, G. A., McCall, W. V., & Pollock, J. S. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02755 · Cited by 98 · see citing works
Adverse Childhood Experience-conditioned serum from young adults promotes a dysregulated endothelial cell gene expression profile
Gagnon, M. K. (2023) · Brock University Digital Repository (Brock University)

Authors: Jenkins, N. D. M., Rogers, E. M., Banks, N. F., Tomko, P. M., Sciarrillo, C. M., Emerson, S. R., Taylor, A., & Teague, T. K.
Affiliations: University of Iowa (US)
Kent State University (US)
Oklahoma State University (US)
University of Oklahoma - Tulsa (US)
Corresponding author: Jenkins, Nathaniel D. M.
ORCID: Jenkins, Nathaniel D. M.
Rogers, Emily M.
Banks, Nile F.
Tomko, Patrick M.
Sciarrillo, Christina M.
Emerson, Sam R.
Taylor, Ashlee
Teague, T. Kent
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2021-09-01
Volume: 321
Issue: 3
Pages: H532-H541
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.00123.2021
PMC: PMC8461842
OpenAlex: W3184772494
Cited by: 42
References: 48
Citations by year: 2026: 6 · 2025: 12 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 2
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Maynooth University ePrints and eTheses Archive (Maynooth University) (acceptedVersion)
Funders: HHS | NIH | National Institute of General Medical Sciences (P20GM109097)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: adverse childhood experiences, psychosocial stress, endothelial dysfunction, SIRT1, sirtuins, oxidative stress, nitric oxide bioavailability, exercise intervention, young adult women, vascular function
MeSH terms: Adverse Childhood Experiences, Adolescent, Adult, Aged, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Stress, Psychological, Oxidative Stress, Sirtuin 1

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Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood

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