Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries
Abstract
To assess the influence of initial diameter on the gender difference in flow-dependent dilatation (FDD) of the conduit artery, we measured radial artery internal diameter (echotracking), flow (Doppler) and total blood viscosity in 24 healthy (25 +/- 0.8 yr) men and women during reactive hyperemia (RH) and during a gradual hand skin heating (SH). At baseline, mean diameter (men, 2.76 +/- 0.09 vs. women, 2.32 +/- 0.07 mm, P < 0.05), flow (men, 21 +/- 4 vs. women, 10 +/- 1 ml/min, P < 0.05), and blood viscosity (men, 4.13 +/- 0.07 vs. women, 3.92 +/- 0.13 cP, P < 0.05) were higher in men but mean shear stress (MSS) was not different between groups. During RH, the percent increase in diameter was lower in men (men, 9 +/- 1 vs. women, 13 +/- 1%, P < 0.05). This difference was suppressed after correction for baseline diameter. During SH, the increase in diameter with flow was higher in women (P < 0.01). However, the increase in MSS was higher in women because of their smaller diameter at each level of flow (P < 0.01) and there was no difference between groups for the increase in diameter at each level of MSS. These results demonstrate in a direct manner that initial diameter influences the magnitude of FDD of conduit arteries in humans by modifying the value of the arterial wall shear stress at each level of flow and support the interest of the heating method in presence of heterogeneous groups.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Significant differences in artery diameter lead to significantly different radial artery flow rates, with a flow rate of 21 ± 4 and 10 ± 1 mL/min for males and females, respectively.
“These significant differences in artery diameter lead to significantly different radial artery flow rates as well, with a flow rate of 21 ± 4 and 10 ± 1 mL/min for males and females, respectively [102].”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [102]
Cites
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Joannidès, R., Haefeli, W. E., Linder, L., Richard, V. J., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622 · see citing works
Self-citationMcDonald, D. A. (1963) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196301000-00017 · Cited by 1,568 · see citing works
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
Pohl, U., Holtz, J., Busse, R., & Bassenge, E. (1986) · Hypertension · doi:10.1161/01.hyp.8.1.37 · Cited by 984 · see citing works
Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701 · see citing works
Haynes, M. P., Sinha, D., Russell, K. S., Collinge, M., Fulton, D. J., Morales‐Ruiz, M., Sessa, W. C., & Bender, J. R. (2000) · Circulation Research · doi:10.1161/01.res.87.8.677 · Cited by 576 · see citing works
Hashimoto, M., Akishita, M., Eto, M., Ishikawa, M., Kozaki, K., Toba, K., Sagara, Y., Taketani, Y., Orimo, H., & Ouchi, Y. (1995) · Circulation · doi:10.1161/01.cir.92.12.3431 · Cited by 574 · see citing works
Menopause Is Associated With Endothelial Dysfunction in Women
Taddei, S., Virdis, A., Ghiadoni, L., Mattei, P., Sudano, I., Bernini, G., Pinto, S., & Salvetti, A. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.576 · Cited by 472 · see citing works
Role of nitric oxide in the vascular effects of local warming of the skin in humans
Kellogg, D. L., Liu, Y., Kosiba, I. F., & O’Donnell, D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.4.1185 · Cited by 463 · see citing works
Flow-mediated and reflex changes in large peripheral artery tone in humans.
Anderson, E. A., & Mark, A. L. (1989) · Circulation · doi:10.1161/01.cir.79.1.93 · Cited by 275 · see citing works
Effect of high local temperature on reflex cutaneous vasodilation
Taylor, W. F., Johnson, J. M., O’Leary, D. S., & Park, M. K. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.1.191 · Cited by 275 · see citing works
Rubanyi, G. M., Freay, A. D., Kauser, K. Z., Sukovich, D. A., Burton, G. A., Lubahn, D. B., Couse, J. F., Curtis, S. W., & Korach, K. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119426 · Cited by 270 · see citing works
Tardy, Y., Meister, J. ‐., Perret, F., Brunner, H. R., & Arditi, M. (1991) · Clinical Physics and Physiological Measurement · doi:10.1088/0143-0815/12/1/003 · Cited by 268 · see citing works
Arnal, J., Clamens, S., Pechet, C., Nègre‐Salvayre, A., Allera, C., Girolami, J. P., Salvayre, R., & Bayard, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4108 · Cited by 254 · see citing works
Lamontagne, D., Pohl, U., & Busse, R. (1992) · Circulation Research · doi:10.1161/01.res.70.1.123 · Cited by 252 · see citing works
Skin and muscle components of forearm blood flow in directly heated resting man.
Detry, J. M., Brengelmann, G. L., Rowell, L. B., & WYSS, C. R. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.4.506 · Cited by 211 · see citing works
Estrogen Enhances Basal Nitric Oxide Release in the Forearm Vasculature in Perimenopausal Women
Sudhir, K., Jennings, G., Funder, J. W., & Komesaroff, P. A. (1996) · Hypertension · doi:10.1161/01.hyp.28.3.330 · Cited by 189 · see citing works
Wall shear stress in the human common carotid artery as function of age and gender
Samijo, S. K., Willigers, J. M., Barkhuysen, R., Kitslaar, P. J. E. H. M., Reneman, R. S., Brands, P. J., & Hoeks, A. P. G. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00074-1 · Cited by 188 · see citing works
Localized Expression of Aromatase in Human Vascular Tissues
Harada, N., Sasano, H., Murakami, H., Ohkuma, T., Nagura, H., & Takagi, Y. (1999) · Circulation Research · doi:10.1161/01.res.84.11.1285 · Cited by 184 · see citing works
Waßmann, S., Bäumer, A. T., Strehlow, K., van Eickels, M., Grohé, C., Ahlbory, K., Rösen, R., Böhm, M., & Nickenig, G. (2001) · Circulation · doi:10.1161/01.cir.103.3.435 · Cited by 181 · see citing works
Long-Term Estrogen Therapy Improves Vascular Function in Male to Female Transsexuals
New, G., Timmins, K. L., Duffy, S. J., Tran, B. T., O’Brien, R. C., Harper, R. W., & Meredith, I. T. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00080-6 · Cited by 165 · see citing works
Androgen Deprivation Is Associated With Enhanced Endothelium-Dependent Dilatation in Adult Men
Herman, S. M., Robinson, J. T. C., McCredie, R. J., Adams, M. R., Boyer, M. J., & Celermajer, D. S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2004 · Cited by 165 · see citing works
Flow-dependent vasodilation of brachial artery in essential hypertension
Laurent, S., Lacolley, P. J., Brunel, P., Laloux, B., Pannier, B., & Safar, M. E. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.4.h1004 · Cited by 150 · see citing works
Heat of evaporation of sweat: thermodynamic considerations.
Wenger, C. B. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.4.456 · Cited by 148 · see citing works
Lambert, J., Aarsen, M., Donker, A. J. M., & Stehouwer, C. D. A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.5.705 · Cited by 141 · see citing works
Resting and maximal forearm skin blood flows are reduced in hypertension.
Carberry, P. A., Shepherd, A. M. M., & Johnson, J. M. (1992) · Hypertension · doi:10.1161/01.hyp.20.3.349 · Cited by 112 · see citing works
Berdeaux, A., Ghaleh, B., Dubois-Randé, J.-L., Vigué, B., Rochelle, C. D. L., Hittinger, L., & Giudicelli, J. (1994) · Circulation · doi:10.1161/01.cir.89.6.2799 · Cited by 97 · see citing works
Huang, A., Sun, D., Koller, Á., & Kaley, G. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1571 · Cited by 94 · see citing works
Gender differences in the generation of superoxide anions in the rat aorta
Brandes, R. P., & Mügge, A. (1997) · Life Sciences · doi:10.1016/s0024-3205(96)00663-7 · Cited by 91 · see citing works
Sex differences in endothelial function in normal and hypercholesterolaemic subjects
Chowienczyk, P., Cockcroft, J. R., Brett, S., Ritter, J. M., & Watts, G. F. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91342-0 · Cited by 77 · see citing works
Reproducibility of the vascular response to heating in human skin
Savage, M. V., & Brengelmann, G. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.4.1759 · Cited by 47 · see citing works
Snow, H. M., Markos, F., O'Regan, D. J., et al. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0843h.x · Cited by 36 · see citing works
New, G., Duffy, S. J., Harper, R. W., et al. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03195.x · Cited by 35 · see citing works
Evaluation of the Determinants of Flow — Mediated Radial Artery Vasodilatation in Humans
Joannidès, R., Bakkali, E. H., Richard, V. J., et al. (1997) · Clinical and Experimental Hypertension · doi:10.3109/10641969709083188 · Cited by 35 · see citing works
Effect of nerve block on response of forearm blood flow to local temperature
Wenger, C. B., Stephenson, L. A., & Durkin, M. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.1.227 · Cited by 30 · see citing works
Effect of acute acidosis and alkalosis on leucine kinetics in man
Straumann, E. H., Keller, U. B., Küry, D., et al. (1992) · Clinical Physiology · doi:10.1111/j.1475-097x.1992.tb00292.x · Cited by 28 · see citing works
Existence of a Pb1-like defect center in porous silicon
Xiao, Y., McMahon, T. J., Pánkové, J. I., et al. (1994) · Journal of Applied Physics · doi:10.1063/1.358433 · Cited by 21 · see citing works
Lambert, J., & Cd, S. (1996) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring
Fine, J., Branan, K. L., Rodriguez, A. J., Boonya-ananta, T., Ajmal, Ramella-Roman, J. C., McShane, M. J., & Coté, G. L. (2021) · Biosensors · doi:10.3390/bios11040126 · Cited by 348 · see citing works
Early stage detection of conduit artery endothelial dysfunction in patients with type 1 diabetes
Bellien, J., Costentin, A., Dutheil-Maillochaud, B., Iacob, M., Kuhn, J.-M., Thuillez, C., & Joannides, R. (2010) · Diabetes and Vascular Disease Research · doi:10.1177/1479164109360470 · Cited by 32 · see citing works
Self-citation
- Authors
- Joannides, R., Costentin, A., Iacob, M., Compagnon, P., Lahary, A., & Thuillez, C.
- Affiliations
- Department of Pharmacology and
- Inserm (FR)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2002-04-01
- Volume
- 282
- Issue
- 4
- Pages
- H1262-H1269
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1990563216
- Cited by
- 75
- References
- 39
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- conduit arteries, radial artery, gender differences, arterial diameter, wall shear stress, reactive hyperemia, skin heating, blood viscosity
- MeSH terms
- Analysis of Variance, Blood Flow Velocity, Blood Pressure, Female, Hot Temperature, Hemodynamics, Humans, Hyperemia, Male, Muscle, Smooth, Vascular, Regional Blood Flow, Regression Analysis, Sex Characteristics, Skin, Skin Temperature, Ultrasonography, Vasodilation, Reproducibility of Results, Body Mass Index, Radial Artery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review