Cited by 75Cardiovascular Health and Disease PreventionElasticity and Material ModelingCardiovascular Function and Risk Factors

Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries

Joannides, Robinson, Costentin, Agathe, Iacob, Michaela, Compagnon, Patricia, Lahary, Agnès, Thuillez, Christian·2002·American Journal of Physiology-Heart and Circulatory Physiology

Abstract

To assess the influence of initial diameter on the gender difference in flow-dependent dilatation (FDD) of the conduit artery, we measured radial artery internal diameter (echotracking), flow (Doppler) and total blood viscosity in 24 healthy (25 +/- 0.8 yr) men and women during reactive hyperemia (RH) and during a gradual hand skin heating (SH). At baseline, mean diameter (men, 2.76 +/- 0.09 vs. women, 2.32 +/- 0.07 mm, P < 0.05), flow (men, 21 +/- 4 vs. women, 10 +/- 1 ml/min, P < 0.05), and blood viscosity (men, 4.13 +/- 0.07 vs. women, 3.92 +/- 0.13 cP, P < 0.05) were higher in men but mean shear stress (MSS) was not different between groups. During RH, the percent increase in diameter was lower in men (men, 9 +/- 1 vs. women, 13 +/- 1%, P < 0.05). This difference was suppressed after correction for baseline diameter. During SH, the increase in diameter with flow was higher in women (P < 0.01). However, the increase in MSS was higher in women because of their smaller diameter at each level of flow (P < 0.01) and there was no difference between groups for the increase in diameter at each level of MSS. These results demonstrate in a direct manner that initial diameter influences the magnitude of FDD of conduit arteries in humans by modifying the value of the arterial wall shear stress at each level of flow and support the interest of the heating method in presence of heterogeneous groups.

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Registry

Crossref · 10.1152/ajpheart.00209.2001

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39 of 39 references verified0 citation errors · 0 not checkable

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  • Significant differences in artery diameter lead to significantly different radial artery flow rates, with a flow rate of 21 ± 4 and 10 ± 1 mL/min for males and females, respectively.

    “These significant differences in artery diameter lead to significantly different radial artery flow rates as well, with a flow rate of 21 ± 4 and 10 ± 1 mL/min for males and females, respectively [102].”

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Authors
Joannides, R., Costentin, A., Iacob, M., Compagnon, P., Lahary, A., & Thuillez, C.
Affiliations
  • Department of Pharmacology and
  • Inserm (FR)
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Published
2002-04-01
Volume
282
Issue
4
Pages
H1262-H1269
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
OpenAlex
W1990563216
Cited by
75
References
39
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
conduit arteries, radial artery, gender differences, arterial diameter, wall shear stress, reactive hyperemia, skin heating, blood viscosity
MeSH terms
Analysis of Variance, Blood Flow Velocity, Blood Pressure, Female, Hot Temperature, Hemodynamics, Humans, Hyperemia, Male, Muscle, Smooth, Vascular, Regional Blood Flow, Regression Analysis, Sex Characteristics, Skin, Skin Temperature, Ultrasonography, Vasodilation, Reproducibility of Results, Body Mass Index, Radial Artery

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